دورية أكاديمية
miR-9 Does Not Regulate Lamin A Expression in Metastatic Cells from Lung Adenocarcinoma
| العنوان: | miR-9 Does Not Regulate Lamin A Expression in Metastatic Cells from Lung Adenocarcinoma |
|---|---|
| المؤلفون: | Julien Guinde, Audrey Benoit, Diane Frankel, Stéphane Robert, Kevin Ostacolo, Nicolas Lévy, Philippe Astoul, Patrice Roll, Elise Kaspi |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 5, p 1599 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | lamin a, microrna-9, lung adenocarcinoma, pleural effusions, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | In lung adenocarcinoma, low lamin A expression in pleural metastatic cells has been proposed as a pejorative factor. miR-9 physiologically inhibits the expression of lamin A in neural cells and seems to be a central actor in the carcinogenesis and the metastatic process in lung cancer. Thus, it could be a good candidate to explain the reduction of lamin A expression in lung adenocarcinoma cells. miR-9 expression was analyzed in 16 pleural effusions containing metastatic cells from lung adenocarcinoma and was significantly reduced in patients from the ‘Low lamin A expression’ group compared to patients from the ‘High lamin A expression’ group. Then, carcinoma cells selection by fluorescence-activated cell sorting (FACS) was performed according to epithelial membrane antigen (EMA) expression, reflecting lamin A expression. miR-9 was underexpressed in lamin A− carcinoma cells compared to lamin A+ carcinoma cells in patients from the ‘Low lamin A expression’ group, whereas there was no difference of miR-9 expression between lamin A+ and lamin A− carcinoma cells in patients from the ‘High lamin A expression’ group. These results suggest that miR-9 does not regulate lamin A expression in metastatic cells from lung adenocarcinoma. On the contrary, miR-9 expression was shown to be reduced in lamin A-negative carcinoma cells. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | https://www.mdpi.com/1422-0067/21/5/1599Test; https://doaj.org/toc/1422-0067Test |
| DOI: | 10.3390/ijms21051599 |
| الوصول الحر: | https://doaj.org/article/720ec1b78aee42fdb25a61bb5fbcd9f5Test |
| رقم الانضمام: | edsdoj.720ec1b78aee42fdb25a61bb5fbcd9f5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 |
|---|---|
| DOI: | 10.3390/ijms21051599 |