التفاصيل البيبلوغرافية
العنوان:
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
المؤلفون:
Matteo D’Antonio , Jennifer P. Nguyen , Timothy D. Arthur , Hiroko Matsui , Agnieszka D’Antonio-Chronowska , Kelly A. Frazer , Benjamin M. Neale , Mark Daly , Andrea Ganna , Christine Stevens , Gita A. Pathak , Shea J. Andrews , Masahiro Kanai , Mattia Cordioli , Juha Karjalainen , Renato Polimanti , Matti Pirinen , Nadia Harerimana , Kumar Veerapen , Brooke Wolford , Huy Nguyen , Matthew Solomonson , Rachel G. Liao , Karolina Chwialkowska , Amy Trankiem , Mary K. Balaconis , Caroline Hayward , Anne Richmond , Archie Campbell , Marcela Morris , Chloe Fawns-Ritchie , Joseph T. Glessner , Douglas M. Shaw , Xiao Chang , Hannah Polikowski , Petty E. Lauren , Hung-Hsin Chen , Zhu Wanying , Hakon Hakonarson , David J. Porteous , Jennifer Below , Kari North , Joseph B. McCormick , Paul R.H.J. Timmers , James F. Wilson , Albert Tenesa , Kenton D’Mellow , Shona M. Kerr , Mari E.K. Niemi , Lindokuhle Nkambul , Kathrin Aprile von Hohenstaufen , Ali Sobh , Madonna M. Eltoukhy , Amr M. Yassen , Mohamed A.F. Hegazy , Kamal Okasha , Mohammed A. Eid , Hanteera S. Moahmed , Doaa Shahin , Yasser M. El-Sherbiny , Tamer A. Elhadidy , Mohamed S. Abd Elghafar , Jehan J. El-Jawhari , Attia A.S. Mohamed , Marwa H. Elnagdy , Amr Samir , Mahmoud Abdel-Aziz , Walid T. Khafaga , Walaa M. El-Lawaty , Mohamed S. Torky , Mohamed R. El-shanshory , Chiara Batini , Paul H. Lee , Nick Shrine , Alexander T. Williams , Martin D. Tobin , Anna L. Guyatt , Catherine John , Richard J. Packer , Altaf Ali , Robert C. Free , Xueyang Wang , Louise V. Wain , Edward J. Hollox , Laura D. Venn , Catherine E. Bee , Emma L. Adams , Ahmadreza Niavarani , Bahareh Sharififard , Rasoul Aliannejad , Ali Amirsavadkouhi , Zeinab Naderpour , Hengameh Ansari Tadi , Afshar Etemadi Aleagha , Saeideh Ahmadi , Seyed Behrooz Mohseni Moghaddam , Alireza Adamsara , Morteza Saeedi , Hamed Abdollahi , Abdolmajid Hosseini , Pajaree Chariyavilaskul , Monpat Chamnanphon , Thitima B. Suttichet , Vorasuk Shotelersuk , Monnat Pongpanich , Chureerat Phokaew , Wanna Chetruengchai , Watsamon Jantarabenjakul , Opass Putchareon , Pattama Torvorapanit , Thanyawee Puthanakit , Pintip Suchartlikitwong , Nattiya Hirankarn , Voraphoj Nilaratanakul , Pimpayao Sodsai , Ben M. Brumpton , Kristian Hveem , Cristen Willer , Wei Zhou , Tormod Rogne , Erik Solligard , Bjørn Olav Åsvold , Malak Abedalthagafi , Manal Alaamery , Saleh Alqahtani , Dona Baraka , Fawz Al Harthi , Ebtehal Alsolm , Leen Abu Safieh , Albandary M. Alowayn , Fatimah Alqubaishi , Amal Al Mutairi , Serghei Mangul , Abdulraheem Alshareef , Mona Sawaji , Mansour Almutairi , Nora Aljawini , Nour Albesher , Yaseen M. Arabi , Ebrahim S. Mahmoud , Amin K. Khattab , Roaa T. Halawani , Ziab Z. Alahmadey , Jehad K. Albakri , Walaa A. Felemban , Bandar A. Suliman , Rana Hasanato , Laila Al-Awdah , Jahad Alghamdi , Deema AlZahrani , Sameera AlJohani , Hani Al-Afghani , May Alrashed , Nouf AlDhawi , Hadeel AlBardis , Sarah Alkwai , Moneera Alswailm , Faisal Almalki , Maha Albeladi , Iman Almohammed , Eman Barhoush , Anoud Albader , Salam Massadeh , Abdulaziz AlMalik , Sara Alotaibi , Bader Alghamdi , Junghyun Jung , Mohammad S. Fawzy , Yunsung Lee , Per Magnus , Lill-Iren S. Trogstad , Øyvind Helgeland , Jennifer R. Harris , Massimo Mangino , Tim D. Spector , Duncan Emma , Sandra P. Smieszek , Bartlomiej P. Przychodzen , Christos Polymeropoulos , Vasilios Polymeropoulos , Mihael H. Polymeropoulos , Israel Fernandez-Cadenas , Jordi Perez-Tur , Laia Llucià-Carol , Natalia Cullell , Elena Muiño , Jara Cárcel-Márquez , Marta L. DeDiego , Lara Lloret Iglesias , Anna M. Planas , Alex Soriano , Veronica Rico , Daiana Agüero , Josep L. Bedini , Francisco Lozano , Carlos Domingo , Veronica Robles , Francisca Ruiz-Jaén , Leonardo Márquez , Juan Gomez , Eliecer Coto , Guillermo M. Albaiceta , Marta García-Clemente , David Dalmau , Maria J. Arranz , Beatriz Dietl , Alex Serra-Llovich , Pere Soler , Roger Colobrán , Andrea Martín-Nalda , Alba Parra Martínez , David Bernardo , Silvia Rojo , Aida Fiz-López , Elisa Arribas , Paloma de la Cal-Sabater , Tomás Segura , Esther González-Villa , Gemma Serrano-Heras , Joan Martí-Fàbregas , Elena Jiménez-Xarrié , Alicia de Felipe Mimbrera , Jaime Masjuan , Sebastian García-Madrona , Anna Domínguez-Mayoral , Joan Montaner Villalonga , Paloma Menéndez-Valladares , Daniel I. Chasman , Julie E. Buring , Paul M. Ridker , Giulianini Franco , Howard D. Sesso , JoAnn E. Manson , Joseph R. Glessner , Carolina Medina-Gomez , Andre G. Uitterlinden , M. Arfan Ikram , Kati Kristiansson , Sami Koskelainen , Markus Perola , Kati Donner , Katja Kivinen , Aarno Palotie , Samuli Ripatti , Sanni Ruotsalainen , Mari Kaunisto , null FinnGen , Tomoko Nakanishi , Guillaume Butler-Laporte , Vincenzo Forgetta , David R. Morrison , Biswarup Ghosh , Laetitia Laurent , Alexandre Belisle , Danielle Henry , Tala Abdullah , Olumide Adeleye , Noor Mamlouk , Nofar Kimchi , Zaman Afrasiabi , Nardin Rezk Branka Vulesevic , Meriem Bouab , Charlotte Guzman , Louis Petitjean , Chris Tselios , Xiaoqing Xue , Erwin Schurr , Jonathan Afilalo , Marc Afilalo , Maureen Oliveira , Bluma Brenner , Pierre Lepage , Jiannis Ragoussis , Daniel Auld , Nathalie Brassard , Madeleine Durand , Michaël Chassé , Daniel E. Kaufmann , G. Mark Lathrop , Vincent Mooser , J. Brent Richards , Rui Li , Darin Adra , Souad Rahmouni , Michel Georges , Michel Moutschen , Benoit Misset , Gilles Darcis , Julien Guiot , Julien Guntz , Samira Azarzar , Stéphanie Gofflot , Yves Beguin , Sabine Claassen , Olivier Malaise , Pascale Huynen , Christelle Meuris , Marie Thys , Jessica Jacques , Philippe Léonard , Frederic Frippiat , Jean-Baptiste Giot , Anne-Sophie Sauvage , Christian Von Frenckell , Yasmine Belhaj , Bernard Lambermont , Sara Pigazzini , Lindokuhle Nkambule , Michelle Daya , Jonathan Shortt , Nicholas Rafaels , Stephen J. Wicks , Kristy Crooks , Kathleen C. Barnes , Christopher R. Gignoux , Sameer Chavan , Triin Laisk , Kristi Läll , Maarja Lepamets , Reedik Mägi , Tõnu Esko , Ene Reimann , Lili Milani , Helene Alavere , Kristjan Metsalu , Mairo Puusepp , Andres Metspalu , Paul Naaber , Edward Laane , Jaana Pesukova , Pärt Peterson , Kai Kisand , Jekaterina Tabri , Raili Allos , Kati Hensen , Joel Starkopf , Inge Ringmets , Anu Tamm , Anne Kallaste , Pierre-Yves Bochud , Carlo Rivolta , Stéphanie Bibert , Mathieu Quinodoz , Dhryata Kamdar , Noémie Boillat , Semira Gonseth Nussle , Werner Albrich , Noémie Suh , Dionysios Neofytos , Véronique Erard , Cathy Voide , null FHoGID , null RegCOVID , null P-PredictUs , null SeroCOVID , null CRiPSI , Rafael de Cid , Iván Galván-Femenía , Natalia Blay , Anna Carreras , Beatriz Cortés , Xavier Farré , Lauro Sumoy , Victor Moreno , Josep Maria Mercader , Marta Guindo-Martinez , David Torrents , Manolis Kogevinas , Judith Garcia-Aymerich , Gemma Castaño-Vinyals , Carlota Dobaño , Alessandra Renieri , Francesca Mari , Chiara Fallerini , Sergio Daga , Elisa Benetti , Margherita Baldassarri , Francesca Fava , Elisa Frullanti , Floriana Valentino , Gabriella Doddato , Annarita Giliberti , Rossella Tita , Sara Amitrano , Mirella Bruttini , Susanna Croci , Ilaria Meloni , Maria Antonietta Mencarelli , Caterina Lo Rizzo , Anna Maria Pinto , Giada Beligni , Andrea Tommasi , Laura Di Sarno , Maria Palmieri , Miriam Lucia Carriero , Diana Alaverdian , Stefano Busani , Raffaele Bruno , Marco Vecchia , Mary Ann Belli , Nicola Picchiotti , Maurizio Sanarico , Marco Gori , Simone Furini , Stefania Mantovani , Serena Ludovisi , Mario Umberto Mondelli , Francesco Castelli , Eugenia Quiros-Roldan , Melania Degli Antoni , Isabella Zanella , Massimo Vaghi , Stefano Rusconi , Matteo Siano , Francesca Montagnani , Arianna Emiliozzi , Massimiliano Fabbiani , Barbara Rossetti , Elena Bargagli , Laura Bergantini , Miriana D’Alessandro , Paolo Cameli , David Bennett , Federico Anedda , Simona Marcantonio , Sabino Scolletta , Federico Franchi , Maria Antonietta Mazzei , Susanna Guerrini , Edoardo Conticini , Luca Cantarini , Bruno Frediani , Danilo Tacconi , Chiara Spertilli , Marco Feri , Alice Donati , Raffaele Scala , Luca Guidelli , Genni Spargi , Marta Corridi , Cesira Nencioni , Leonardo Croci , Maria Bandini , Gian Piero Caldarelli , Paolo Piacentini , Elena Desanctis , Silvia Cappelli , Anna Canaccini , Agnese Verzuri , Valentina Anemoli , Agostino Ognibene , Alessandro Pancrazzi , Maria Lorubbio , Antonella D’Arminio Monforte , Federica Gaia Miraglia , Massimo Girardis , Sophie Venturelli , Andrea Cossarizza , Andrea Antinori , Alessandra Vergori , Arianna Gabrieli , Agostino Riva , Daniela Francisci , Elisabetta Schiaroli , Francesco Paciosi , Pier Giorgio Scotton , Francesca Andretta , Sandro Panese , Renzo Scaggiante , Francesca Gatti , Saverio Giuseppe Parisi , Stefano Baratti , Matteo Della Monica , Carmelo Piscopo , Mario Capasso , Roberta Russo , Immacolata Andolfo , Achille Iolascon , Giuseppe Fiorentino , Massimo Carella , Marco Castori , Giuseppe Merla , Gabriella Maria Squeo , Filippo Aucella , Pamela Raggi , Carmen Marciano , Rita Perna , Matteo Bassetti , Antonio Di Biagio , Maurizio Sanguinetti , Luca Masucci , Serafina Valente , Marco Mandalà , Alessia Giorli , Lorenzo Salerni , Patrizia Zucchi , Pierpaolo Parravicini , Elisabetta Menatti , Tullio Trotta , Ferdinando Giannattasio , Gabriella Coiro , Fabio Lena , Domenico A. Coviello , Cristina Mussini , Enrico Martinelli , Sandro Mancarella , Luisa Tavecchia , Lia Crotti , Chiara Gabbi , Marco Rizzi , Franco Maggiolo , Diego Ripamonti , Tiziana Bachetti , Maria Teresa La Rovere , Simona Sarzi-Braga , Maurizio Bussotti , Stefano Ceri , Pietro Pinoli , Francesco Raimondi , Filippo Biscarini , Alessandra Stella , Kristina Zguro , Katia Capitani , Claudia Suardi , Simona Dei , Gianfranco Parati , Sabrina Ravaglia , Rosangela Artuso , Giordano Bottà , Paolo Di Domenico , Ilaria Rancan , Antonio Perrella Francesco Bianchi , Davide Romani , Paola Bergomi , Emanuele Catena , Riccardo Colombo , Marco Tanfoni , Antonella Vincenti , Claudio Ferri , Davide Grassi , Gloria Pessina , Mario Tumbarello , Massimo Di Pietro , Ravaglia Sabrina , Sauro Luchi , Chiara Barbieri , Donatella Acquilini , Elena Andreucci , Francesco Vladimiro Segala , Giusy Tiseo , Marco Falcone , Mirjam Lista , Monica Poscente , Oreste De Vivo , Paola Petrocelli , Alessandra Guarnaccia , Silvia Baroni , Albert V. Smith , Andrew P. Boughton , Kevin W. Li , Jonathon LeFaive , Aubrey Annis , Anne E. Justice , Tooraj Mirshahi , Geetha Chittoor , Navya Shilpa Josyula , Jack A. Kosmicki , Manuel A.R. Ferreira , Joseph B. Leader , Dave J. Carey , Matthew C. Gass , Julie E. Horowitz , Michael N. Cantor , Ashish Yadav , Aris Baras , Goncalo R. Abecasis , David A. van Heel , Karen A. Hunt , Dan Mason , Qin Qin Huang , Sarah Finer , null Genes & Health Research Team , Bhavi Trivedi , Christopher J. Griffiths , Hilary C. Martin , John Wright , Richard C. Trembath , Nicole Soranzo , Jing Hua Zhao , Adam S. Butterworth , John Danesh , Emanuele Di Angelantonio , Lude Franke Marike Boezen , Patrick Deelen , Annique Claringbould , Esteban Lopera , Robert Warmerdam , Judith.M. Vonk , Irene van Blokland , Pauline Lanting , Anil P.S. Ori , Brooke Wolford Sebastian Zöllner , Jiongming Wang , Andrew Beck , Gina Peloso , Yuk-Lam Ho , Yan V. Sun , Jennifer E. Huffman , Christopher J. O’Donnell , Kelly Cho , Phil Tsao , J. Michael Gaziano , Michel (M.G.) Nivard , Eco (E.J.C.) de geus , Meike Bartels , Jouke Jan Hottenga , Scott T. Weiss , Elizabeth W. Karlson , Jordan W. Smoller , Robert C. Green , Yen-Chen Anne Feng , Josep Mercader , Shawn N. Murphy , James B. Meigs , Ann E. Woolley , Emma F. Perez , Daniel Rader , Anurag Verma , Marylyn D. Ritchie , Binglan Li , Shefali S. Verma , Anastasia Lucas , Yuki Bradford , Hugo Zeberg , Robert Frithiof , Michael Hultström , Miklos Lipcsey , Lindo Nkambul , Nicolas Tardif , Olav Rooyackers , Jonathan Grip , Tomislav Maricic , Konrad J. Karczewski , Elizabeth G. Atkinson , Kristin Tsuo , Nikolas Baya , Patrick Turley , Rahul Gupta , Shawneequa Callier , Raymond K. Walters , Duncan S. Palmer , Gopal Sarma , Nathan Cheng , Wenhan Lu , Sam Bryant , Claire Churchhouse , Caroline Cusick , Jacqueline I. Goldstein , Daniel King , Cotton Seed , Hilary Finucane , Alicia R. Martin , F. Kyle Satterstrom , Daniel J. Wilson , Jacob Armstrong , Justine K. Rudkin , Gavin Band , Sarah G. Earle , Shang-Kuan Lin , Nicolas Arning , Derrick W. Crook , David H. Wyllie , Anne Marie O’Connell , Chris C.A. Spencer , Nils Koelling , Mark J. Caulfield , Richard H. Scott , Tom Fowler , Loukas Moutsianas , Athanasios Kousathanas , Dorota Pasko , Susan Walker , Augusto Rendon , Alex Stuckey , Christopher A. Odhams , Daniel Rhodes , Georgia Chan , Prabhu Arumugam , Catherine A. Ball , Eurie L. Hong , Kristin Rand , Ahna Girshick , Harendra Guturu , Asher Haug Baltzell , Genevieve Roberts , Danny Park , Marie Coignet , Shannon McCurdy , Spencer Knight , Raghavendran Partha , Brooke Rhead , Miao Zhang , Nathan Berkowitz , Michael Gaddis , Keith Noto , Luong Ruiz , Milos Pavlovic , Laura G. Sloofman , Alexander W. Charney , Noam D. Beckmann , Eric E. Schadt , Daniel M. Jordan , Ryan C. Thompson , Kyle Gettler , Noura S. Abul-Husn , Steven Ascolillo , Joseph D. Buxbaum , Kumardeep Chaudhary , Judy H. Cho , Yuval Itan , Eimear E. Kenny , Gillian M. Belbin , Stuart C. Sealfon , Robert P. Sebra , Irene Salib , Brett L. Collins , Tess Levy , Bari Britvan , Katherine Keller , Lara Tang , Michael Peruggia , Liam L. Hiester , Kristi Niblo , Alexandra Aksentijevich , Alexander Labkowsky , Avromie Karp , Menachem Zlatopolsky , Michael Preuss , Ruth J.F. Loos , Girish N. Nadkarni , Ron Do , Clive Hoggart , Sam Choi , Slayton J. Underwood , Paul O’Reilly , Laura M. Huckins , Marissa Zyndorf
المساهمون:
AII - Infectious diseases, Amsterdam Neuroscience - Neuroinfection & -inflammation, Neurology
المصدر:
Cell Reports
بيانات النشر:
Elsevier BV, 2022.
سنة النشر:
2022
مصطلحات موضوعية:
Medical Physiology , Gene Expression , Genome-wide association study , Genome , Severity of Illness Index , colocalization , Gene expression , Databases, Genetic , Ethnicity , 2.1 Biological and endogenous factors , GWAS , Aetiology , Biology (General) , Lung , Genetics , Chromosome Mapping , Single Nucleotide , Organ Specificity , Biotechnology , Cell type , QH301-705.5 , Quantitative Trait Loci , Single-nucleotide polymorphism , Biology , eQTL , Polymorphism, Single Nucleotide , Article , General Biochemistry, Genetics and Molecular Biology , Databases , Genetic , SNP , Humans , Genetic Predisposition to Disease , COVID-19 Host Genetics Initiative , Polymorphism , Gene , COVID-19 , SARS-CoV-2 , Gene Expression Profiling , Prevention , Human Genome , Computational Biology , Genetic Variation , Good Health and Well Being , Expression quantitative trait loci , Biochemistry and Cell Biology , Transcriptome , Genome-Wide Association Study
الوصف:
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types.
وصف الملف:
application/pdf
تدمد:
2211-1247
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a560c6a75c5d279fbfffef0ff0d505Test https://doi.org/10.1016/j.celrep.2022.110968Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....c3a560c6a75c5d279fbfffef0ff0d505
قاعدة البيانات:
OpenAIRE
