نتائج البحث

1

The HCN Channel Blocker ZD7288 Induces Emesis in the Least Shrew (Cryptotis parva)

المؤلفون: Nissar A. Darmani, Weixia Zhong

المصدر: Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology

مصطلحات موضوعية: Agonist, medicine.drug_class, RM1-950, Pharmacology, ZD7288, chemistry.chemical_compound, Dopamine, Tachykinin receptor 1, medicine, HCN channel, Netupitant, Pharmacology (medical), Original Research, calcium, biology, Area postrema, emesis, emetic nuclei, Dorsal motor nucleus, chemistry, biology.protein, Serotonin, Therapeutics. Pharmacology, least shrew, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a45a7d50b1774dd20079d6ffdd7205eTest
https://www.frontiersin.org/articles/10.3389/fphar.2021.647021/fullTest

2

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

المؤلفون: Gereon R. Fink, Michael Schroeter, Helena Monière, Igor Jakovcevski, Helene Luise Walter, Maria Adele Rueger, Stefan Blaschke, Pavle R. Andjus, Lea Jessica Flitsch, Sabine Ulrike Vay, Dunja Bijelić, Monika Rabenstein

المصدر: Journal of Neuroinflammation
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-17 (2020)
Journal of neuroinflammation 17(1), 100 (2020). doi:10.1186/s12974-020-01779-4

مصطلحات موضوعية: Small interfering RNA, siHCN2, Immunology, ZD7288, lcsh:RC346-429, Ih-current, Voltage sensor probes, Cellular and Molecular Neuroscience, Phagocytosis, Neuroinflammation, HCN channel, medicine, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Potassium Channel Blockers, Animals, XE-991, ddc:610, Rats, Wistar, lcsh:Neurology. Diseases of the nervous system, Ion channel, Migration, Cell Proliferation, Microglia activation, Voltage-gated ion channel, biology, Microglia, Chemistry, General Neuroscience, Research, Depolarization, Hyperpolarization (biology), Cerebral ischemia, Cell biology, Rats, medicine.anatomical_structure, Pyrimidines, Neurology, nervous system, Potassium Channels, Voltage-Gated, biology.protein, Calcium, RNA Interference, Microglia phenotype

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::612d1d84b8293bddda4490eb49aaf3b6Test
https://pubmed.ncbi.nlm.nih.gov/32248813Test

3

The role of HCN channels in peristaltic dysfunction in human ureteral tuberculosis

المؤلفون: Xingyou Dong, Qian Liu, Shanhong Yi, Xiaoyan Hu, Zhenxing Yang, Fan He, Longkun Li, Zhenqiang Fang

المصدر: International Urology and Nephrology

مصطلحات موضوعية: Male, medicine.medical_specialty, Contraction (grammar), Potassium Channels, Urology, medicine.medical_treatment, 030232 urology & nephrology, Tuberculous ureter, Muscle Proteins, Tuberculosis, Urogenital, ZD7288, Tissue Culture Techniques, 03 medical and health sciences, 0302 clinical medicine, Ureter, medicine, HCN channel, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Humans, Ureteral Diseases, Peristalsis, Mucous Membrane, biology, Urology - Original Paper, business.industry, Spontaneous contraction, Cardiovascular Agents, Muscle, Smooth, Middle Aged, Nephrectomy, Potassium channel, HCN, medicine.anatomical_structure, Pyrimidines, Nephrology, c-kit, 030220 oncology & carcinogenesis, Cardiovascular agent, biology.protein, Female, medicine.symptom, business, Muscle contraction, Muscle Contraction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa5b125ce76416f3e7153e3229441bdTest
http://europepmc.org/articles/PMC5878205Test

4

Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility

المؤلفون: Felix Mader, Armin Springer, Tristan Wittstock, Oliver W. Hakenberg, Timo Kirschstein, Karoline Kernig, Rüdiger Köhling, Simone Rackow, Marcus Frank, Steffen Müller, Chris Protzel, Katrin Porath, Ludwig Krause

المصدر: Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c9dfc9d29b0733f5a7abf3206db1780Test
https://pubmed.ncbi.nlm.nih.gov/29971015Test

5

The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission

المؤلفون: Yuji Inaba, Giuseppe Biagini, Massimo Avoli

المصدر: Neuropharmacology. 51:681-691

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f05e21e89d23dd6262eb1a6a96eac4Test
https://doi.org/10.1016/j.neuropharm.2006.05.017Test

6

ZD7288, a blocker of the HCN channel family, increases doubling time of mouse embryonic stem cells and modulates differentiation outcomes in a context-dependent manner

المؤلفون: Petra Sekyrova, Michael Andäng, Anna Omelyanenko

المصدر: SpringerPlus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a70a743db0e6cb517763e04bceb8c6Test
https://doi.org/10.1186/s40064-016-1678-7Test

7

Characterization of the role of HCN channels in β3-adrenoceptor mediated rat bladder relaxation

المؤلفون: Phillip P. Smith, Naoki Yoshimura, Michael B. Chancellor, Pradeep Tyagi, Mahendra Kashyap

المصدر: Bladder

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df6f60c7b8803c79463253f8314a319Test
http://europepmc.org/articles/PMC4690542Test

8

ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity

المؤلفون: Min Zheng, Xiaoxue Zhang, Xulin Xu, Lianjun Guo, Xiao-chun Min

المصدر: Neural Regeneration Research
Neural Regeneration Research, Vol 11, Iss 5, Pp 779-786 (2016)

مصطلحات موضوعية: 0301 basic medicine, Hippocampal formation, Biology, ZD7288, lcsh:RC346-429, nerve regeneration, I h channels, perforant path-CA3 synapse, long-term potentiation, field excitatory postsynaptic potentials, glutamate release, neural regeneration, 03 medical and health sciences, 0302 clinical medicine, Developmental Neuroscience, In vivo, perforant path–CA3 synapse, Channel blocker, Ih channels, lcsh:Neurology. Diseases of the nervous system, Hippocampal synaptic plasticity, Glutamate receptor, Long-term potentiation, Hyperpolarization (biology), 030104 developmental biology, Excitatory postsynaptic potential, Biophysics, Neuroscience, 030217 neurology & neurosurgery, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24e4ed94a02e49fd0a6f4353c279eceTest
https://doi.org/10.4103/1673-5374.182705Test

9

Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels

المؤلفون: Ka-Wing Au, Hung-Fat Tse, Yau-Chi Chan, Kai Wang, Chu-Pak Lau, Ronald A. Li

المصدر: Pflugers Archiv
Chan, Yau-Chi; Wang, Kai; Wing Au, Ka; Lau, Chu-Pak; Tse, Hung-Fat; & Li, Ronald A.(2009). Probing the bradycardic drug binding receptor of HCN-encoded pacemaker channels. Pflügers Archiv-European Journal of Physiology: European Journal of Physiology, 459(1), pp 25-38. doi: 10.1007/s00424-009-0719-2. Retrieved from: http://www.escholarship.org/uc/item/7zc2618mTest

مصطلحات موضوعية: Cardiotonic Agents, Patch-Clamp Techniques, Potassium Channels, Protein Structure, Quaternary - drug effects, Physiology, Molecular Sequence Data, Clinical Biochemistry, Cyclic Nucleotide-Gated Cation Channels, 030204 cardiovascular system & hematology, Biology, Cardiovascular Physiology, ZD7288, Inner pore, 03 medical and health sciences, Mice, 0302 clinical medicine, Protein structure, Physiology (medical), Potassium Channels - chemistry - metabolism, Bradycardia, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels, Animals, Humans, Patch clamp, Amino Acid Sequence, Receptor, Protein Structure, Quaternary, 030304 developmental biology, Pyrimidines - pharmacology, 0303 health sciences, HEK 293 cells, Wild type, Alanine scanning, Cardiotonic Agents - pharmacology, Potassium channel, HCN, 3. Good health, Biomedicine, Pyrimidines, Cyclic Nucleotide-Gated Cation Channels - chemistry - metabolism, Human Physiology, Biochemistry, Microscopy, Fluorescence, Pacemaker channels, Biophysics, Drug receptor, Drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5239dba61d524614f972f324eb1fdebTest
http://hdl.handle.net/10722/144954Test

10

Purkinje-like cells of the rat cochlear nucleus: A combined functional and morphological study

المؤلفون: Géza Szucs, Balázs Pál, Zoltán Rusznák, Krisztina Pocsai, Aron Koszeghy, Zsuzsanna S. Nagy, Pál Pap

المساهمون: Élettani Intézet -- 10, ÁOK -- OEC, Debreceni Egyetem

مصطلحات موضوعية: Male, Calbindins, Auditory Pathways, Patch-Clamp Techniques, analysis, Action Potentials, Fluorescent Antibody Technique, Synaptic Transmission, Calbindin, ZD7288, Purkinje Cells, Postsynaptic potential, morphology, neurone, rat, Elméleti orvostudományok, gamma-Aminobutyric Acid, action potentials, Neurons, Purkinje, Glutamate Decarboxylase, General Neuroscience, GAD, Depolarization, Orvostudományok, Immunohistochemistry, CN, IPSC, Auditory Perception, Excitatory postsynaptic potential, method, GABAergic, Female, Cochlear Nucleus, Purkinje-like, Glycine, Nerve Tissue Proteins, Biology, Inhibitory postsynaptic potential, Cochlear nucleus, methods, Organ Culture Techniques, S100 Calcium Binding Protein G, calbindin, Animals, auditory, Rats, Wistar, Cell Shape, Molecular Biology, Staining and Labeling, Postsynaptic current, Excitatory Postsynaptic Potentials, cerebellar, Dendrites, Cerebellin, Electric Stimulation, Rats, Electrophysiology, Inhibitory Postsynaptic Potentials, Synapses, Neurology (clinical), Neuroscience, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9958de7cae0d0b4cbbdd1a59da9caaTest

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