المؤلفون: Arman Javadi, Andrew D. Campbell, Paul G. O’Reilly, Darragh G. McArt, Sandra Van Schaeybroeck, Tim Harrison, Federica Di Nicolantonio, Daniel B. Longley, Jamie Z. Roberts, Alberto Bardelli, Nicolas Vitale, Wendy L. Allen, Markus Rehm, Christopher J. Scott, Joanna Majkut, Owen J. Sansom, Hajrah Khawaja, Emma Evergren, Richard D Kennedy

المساهمون: Institut des Neurosciences Cellulaires et Intégratives (INCI), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2020, 11 (10), ⟨10.1038/s41419-020-03131-3⟩
Khawaja, H, Campbell, A, Roberts, J Z, Javadi, A, O’Reilly, P, McArt, D, Allen, W L, Majkut, J, Rehm, M, Bardelli, A, Di Nicolantonio, F, Scott, C J, Kennedy, R, Vitale, N, Harrison, T, Sansom, O J, Longley, D B, Evergren, E & Van Schaeybroeck, S 2020, ' RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer ', Cell death and disease, vol. 11, no. 10, 930 . https://doi.org/10.1038/s41419-020-03131-3Test
Cell Death and Disease, Vol 11, Iss 10, Pp 1-18 (2020)

مصطلحات موضوعية: Cancer Research, Programmed cell death, Immunology, Cell, Apoptosis, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Transfection, medicine.disease_cause, Article, GTP Phosphohydrolases, Proto-Oncogene Proteins p21(ras), TNF-Related Apoptosis-Inducing Ligand, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Downregulation and upregulation, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, RNA, Messenger, lcsh:QH573-671, 030304 developmental biology, 0303 health sciences, Gene knockdown, RALB, lcsh:Cytology, Oncogenes, Cell Biology, Recombinant Proteins, RALA, Colon cancer, 3. Good health, Receptors, TNF-Related Apoptosis-Inducing Ligand, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Mutation, Cancer research, Benzimidazoles, ral GTP-Binding Proteins, KRAS, Colorectal Neoplasms, Carcinogenesis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ee9cb501a92e26330f31d10bab105d1Test
https://doi.org/10.1038/s41419-020-03131-3Test

المؤلفون: Simon S. McDade, Christopher J. Scott, Luke M Humphreys, Christopher McCann, Joanna Majkut, Catherine A. Higgins, Tamas Sessler, Jennifer Fox, Kirsty McLaughlin, Tim Harrison, Daniel B. Longley, Jamie Z. Roberts, Nyree Crawford

المصدر: EMBO Reports
Humphreys, L M, Fox, J P, Higgins, C A, Majkut, J, Sessler, T, McLaughlin, K, McCann, C, Roberts, J Z, Crawford, N T, McDade, S S, Scott, C J, Harrison, T & Longley, D B 2020, ' A revised model of TRAIL-R2 DISC assembly explains how FLIP(L) can inhibit or promote apoptosis ', EMBO Reports, vol. 21, e49254 . https://doi.org/10.15252/embr.201949254Test

مصطلحات موضوعية: FLIP, CASP8 and FADD-Like Apoptosis Regulating Protein, Ripoptosome, Caspase 8, Biochemistry, caspase-8, Article, TRAIL‐R2, caspase‐8, TNF-Related Apoptosis-Inducing Ligand, 03 medical and health sciences, 0302 clinical medicine, TRAIL-R2, Genetics, Humans, splice, FADD, Molecular Biology, 030304 developmental biology, 0303 health sciences, biology, Chemistry, apoptosis, Signal transducing adaptor protein, Articles, DISC, 3. Good health, Cell biology, Receptors, TNF-Related Apoptosis-Inducing Ligand, Flip, Apoptosis, biology.protein, Autophagy & Cell Death, 030217 neurology & neurosurgery, Intracellular, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a50ab1892f2f3141bf88f1784d3c32Test
https://doi.org/10.15252/embr.201949254Test

المؤلفون: Tim Harrison, Emma Graham, Stephanie Burton, Aaron Gregson, Paul B. Mullan, Sharon L. Eddie, Rich Williams, Roberta E. Burden, Christopher J. Scott

المصدر: Bioorganicmedicinal chemistry letters. 29(12)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Cysteine Proteinase Inhibitors, Legumain, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Molecular Biology, Dipeptide, biology, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Combinatorial chemistry, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cysteine Endopeptidases, chemistry, biology.protein, Molecular Medicine, Linker

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9108f1f3fffaf948ee964ec5836b3eTest
https://pubmed.ncbi.nlm.nih.gov/31005445Test

المؤلفون: Marina Kovaleva, Aaron Cranston, Andrew C.G. Porter, Mark Wappett, Estelle McLean, Chiara Saladino, Graham Cotton, Stacey Bell, Andrei Kamenski, Alicia Campion, Trumper Paul Richard, Jennifer Thom, Elisa Persiani, Aidan P. McCann, Caroline J. Barelle, Tim Harrison

المصدر: Cancer Research. 80:538-538

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Drug discovery, Cancer, medicine.disease, medicine.disease_cause, Receptor tyrosine kinase, In vitro, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, ROR1, medicine, Cancer research, biology.protein, Carcinogenesis, Triple-negative breast cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7c5075206517a9efbcb5c4e86f43aff4Test
https://doi.org/10.1158/1538-7445.am2020-538Test

المؤلفون: Paul B. Mullan, Rich Williams, Stephanie Burton, Kerry Anne Ness, Tim Harrison, Sharon L. Eddie

المصدر: Bioorganic & Medicinal Chemistry Letters. 26:413-416

مصطلحات موضوعية: 0301 basic medicine, Cysteine Endopeptidases, Clinical Biochemistry, Pharmaceutical Science, Legumain, Methylation, Biochemistry, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, Protease Inhibitors, skin and connective tissue diseases, Molecular Biology, Sulfonamides, biology, Chemistry, fungi, Organic Chemistry, Small molecule, Rats, body regions, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, biology.protein, Biophysics, Molecular Medicine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401e4c1606dfc46a0487c9cb7214fb18Test
https://doi.org/10.1016/j.bmcl.2015.11.101Test

المؤلفون: Eamon Cassidy, Peter Hewitt, Elias Arkoudis, Natalie Page, Gerald Gavory, Hugues Miel, J. S. Shane Rountree, Caroline Hughes, Ewa Odrzywol, Keeva McClelland, Matthew Helm, Colin O'Dowd, Scarlett Dvorkin, Tim Harrison, Linda Jordan, Oliver Barker, Stephanie Feutren-Burton, Ewelina Rozycka, Jakub T. Flasz

المصدر: O'Dowd, C R, Helm, M D, Rountree, J S S, Flasz, J T, Arkoudis, E, Miel, H, Hewitt, P R, Jordan, L, Barker, O, Hughes, C, Rozycka, E, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Fuetren-Burton, S, Dvorkin, S, Gavory, G & Harrison, T 2018, ' Identification and structure-guided development of pyrimidinone based USP7 inhibitors ', ACS Medicinal Chemistry Letters, vol. 9, no. 3, pp. 238-243 . https://doi.org/10.1021/acsmedchemlett.7b00512Test

مصطلحات موضوعية: 0301 basic medicine, biology, Drug discovery, Organic Chemistry, Computational biology, Biochemistry, Deubiquitinating enzyme, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Proteasome, Ubiquitin, In vivo, 030220 oncology & carcinogenesis, Drug Discovery, Ubiquitin specific protease, biology.protein, Mdm2, Identification (biology)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f42201b193e5dbba8db4243fe20048Test
https://pubmed.ncbi.nlm.nih.gov/29541367Test

المؤلفون: Natalie Page, Matthew Helm, Anthony Dossang, Colin O'Dowd, Jakub T. Flasz, Elias Arkoudis, Keeva McClelland, Gerald Gavory, Ewa Odrzywol, Eamon Cassidy, Oliver Barker, Tim Harrison, Caroline Hughes, Hugues Miel

المصدر: Gavory, G, O'Dowd, C, Helm, M D, Flasz, J, Arkoudis, E, Dossang, A, Hughes, C, Cassidy, E, McClelland, K, Odrzywol, E, Page, N, Barker, O, Miel, H & Harrison, T 2017, ' Discovery and characterization of highly potent and selective allosteric USP7 inhibitors ', Nature Chemical Biology, vol. 14, pp. 118-125 . https://doi.org/10.1038/nchembio.2528Test

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, medicine.medical_treatment, Allosteric regulation, Druggability, Antineoplastic Agents, Plasma protein binding, Computational biology, Crystallography, X-Ray, Substrate Specificity, Deubiquitinating enzyme, Ubiquitin-Specific Peptidase 7, Inhibitory Concentration 50, 03 medical and health sciences, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Drug Discovery, medicine, Humans, Protease Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, Binding Sites, Protease, biology, Chemistry, Drug discovery, Proto-Oncogene Proteins c-mdm2, Cell Biology, Kinetics, 030104 developmental biology, Enzyme, Drug Design, 030220 oncology & carcinogenesis, biology.protein, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, Oxidation-Reduction, Allosteric Site, Protein Binding

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54bd60b0c724b11afde133cd0d60a09Test
https://pure.qub.ac.uk/en/publications/discovery-and-characterization-of-highly-potent-and-selective-allosteric-usp7-inhibitorsTest(e7597a0f-932a-40c7-93ad-632aa359463e).html

المؤلفون: Iain Simpson, Joanna Boros, Jonathan Tart, Thorsten Nowak, Keeva McClelland, Anne U. Goeppert, Jenna Bradley, Krzysztofa Ewa Odrzywol, Jarrod Walsh, Jonathan D. Wrigley, Lindsey Leach, Andrea Valentine, Jonathan Renshaw, Helen Plant, Richard A. Ward, Gareth M. Davies, Tim Harrison, Gerald Gavory, David M. Andrews, Ewelina Rozycka, Marian Preston

المصدر: Wrigley, J D, Gavory, G, Simpson, I, Preston, M, Plant, H, Bradley, J, Goeppert, A U, Rozycka, E, Davies, G, Walsh, J, Valentine, A, McClelland, K, Odrzywol, K E, Renshaw, J, Boros, J, Tart, J, Leach, L, Nowak, T, Ward, R A, Harrison, T & Andrews, D M 2017, ' Identification and Characterization of Dual Inhibitors of the USP25/ 28 Deubiquitinating Enzyme Subfamily ', ACS Chemical Biology . https://doi.org/10.1021/acschembio.7b00334Test

مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Specific Proteases, Subfamily, Antineoplastic Agents, Computational biology, Biology, Biochemistry, Deubiquitinating enzyme, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Humans, Enzyme Inhibitors, Cell Proliferation, Drug discovery, Target engagement, General Medicine, DUAL (cognitive architecture), HCT116 Cells, 030104 developmental biology, Proteasome, biology.protein, Molecular Medicine, Identification (biology), Ubiquitin Thiolesterase

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f13e61e1f295cc5b9b607aee18a67e6Test
https://pubmed.ncbi.nlm.nih.gov/29131570Test

المؤلفون: Dennis J. Shale, Lucy C. Fairclough, Ola H. Negm, Charlotte E. Bolton, Noor Kalsheker, Ian Todd, Michelle John, Tim Harrison, Patrick J. Tighe, Nichola S. Gale, Amna Almehairi, Reham Shindi

المصدر: Clinical immunology (Orlando, Fla.). 183

مصطلحات موضوعية: 0301 basic medicine, Male, Antigens, Fungal, Microarray, Immunology, Protein Array Analysis, Protein microarray, Pulmonary disease, Autoimmunity, medicine.disease_cause, Autoantigens, Immunoglobulin G, 03 medical and health sciences, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Antigen, medicine, Immunology and Allergy, Humans, Aged, Autoantibodies, COPD, Antigens, Bacterial, biology, business.industry, Chronic obstructive pulmonary disease, Smoking, Autoantibody, Middle Aged, medicine.disease, respiratory tract diseases, 030104 developmental biology, 030228 respiratory system, Immunoglobulin M, biology.protein, Female, business

وصف الملف: PDF; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f890476d5c140846b49447edd7926abcTest
https://pubmed.ncbi.nlm.nih.gov/28951328Test

المؤلفون: Andrew Young, Rich Williams, Samira Bouazzaoui, Paul B. Mullan, Kishore K.D. Gaddale, Amy Templeman, Zenobia C. D’Costa, Christopher J. Scott, Tim Harrison, Martin O'Rourke, Catherine A. Higgins

المصدر: Bioorganic & Medicinal Chemistry Letters. 24:2521-2524

مصطلحات موضوعية: Carbamate, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Legumain, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Enzyme Inhibitors, skin and connective tissue diseases, Molecular Biology, Biphenyl, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Biphenyl Compounds, fungi, Organic Chemistry, Protease inhibitor (biology), body regions, Cysteine Endopeptidases, biology.protein, Molecular Medicine, Carbamates, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1b118f09380d37746c95668d2888edTest
https://doi.org/10.1016/j.bmcl.2014.04.002Test