نتائج البحث

1

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA

المصدر: Journal of Medicinal Chemistry. 64:15214-15249

مصطلحات موضوعية: biology, medicine.drug_class, Chemistry, Topoisomerase IV, Antibiotics, hERG, Pharmacology, DNA gyrase, In vitro, In vivo, Drug Discovery, medicine, biology.protein, Molecular Medicine, Potency, Topoisomerase inhibitor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b3892c880ddb3b3758eba4c921a02b47Test
https://doi.org/10.1021/acs.jmedchem.1c01250Test

2

The Natural Products Atlas 2.0: a database of microbially-derived natural products

المؤلفون: Jeffrey A. van Santen, Alison H. Hughes, Roger G. Linington, Jeffrey D. Rudolf, David P. Fewer, Elisabeth M.-L. Janssen, Trevor N. Clark, Tyler A. Alsup, Claire H. Fergusson, Dasha Iskakova, Jonathan Parra, Katherine R. Duncan, Ella F. Poynton, Sylvia Soldatou, Caitlin A. McCadden, Emily McMann

المساهمون: Department of Microbiology, Department of Food and Nutrition, Helsinki Institute of Sustainability Science (HELSUS), Microbial Natural Products

المصدر: Nucleic Acids Research

مصطلحات موضوعية: RM, Databases, Factual, AcademicSubjects/SCI00010, Dashboard (business), Ontology (information science), Biology, computer.software_genre, 01 natural sciences, Natural (archaeology), Field (computer science), QA76, 03 medical and health sciences, User-Computer Interface, User experience design, Genetics, Database Issue, Humans, 030304 developmental biology, 0303 health sciences, Biological Products, Application programming interface, Database, Bacteria, Host Microbial Interactions, 010405 organic chemistry, business.industry, Fungi, Classification, 0104 chemical sciences, 1182 Biochemistry, cell and molecular biology, Natural Products Chemistry, business, ACCESS, Classifier (UML), computer, Software

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649477591caa8aa7b97596d064977407Test
http://europepmc.org/articles/PMC8728154Test

3

Heterozygous Variants in KDM4B Lead to Global Developmental Delay and Neuroanatomical Defects

المساهمون: Clinical Genetics, Boston Children's Hospital, Unité fonctionnelle d' Innovation en Diagnostic Génomique des Maladies Rares (CHU Dijon) (UF6254), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe GAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre de génétique - Centre de référence des maladies rares, anomalies du développement et syndromes malformatifs (CHU de Dijon), FHU TRANSLAD (CHU de Dijon), The Wellcome Trust Sanger Institute [Cambridge], City University of Hong Kong [Hong Kong] (CUHK), Bambino Gesù Children’s Hospital [Rome, Italy], Università degli Studi di Perugia = University of Perugia (UNIPG), GeneDx [Gaithersburg, MD, USA], Service de génétique médicale, Université de Bordeaux (UB)-CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre hospitalier universitaire de Nantes (CHU Nantes), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Amsterdam UMC - Amsterdam University Medical Center, Centre de référence des maladies rares des déficiences intellectuelles de causes rares (CHU Dijon) (CRMR des déficiences intellectuelles de causes rares), The Hospital for sick children [Toronto] (SickKids), Dupuis, Christine, Human Genetics, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, ACS - Pulmonary hypertension & thrombosis, Amsterdam Reproduction & Development (AR&D), Lelliott, Christopher [0000-0001-8087-4530], Apollo - University of Cambridge Repository

المصدر: Am J Hum Genet
American Journal of Human Genetics, 107(6), 1170-1177. Cell Press
American Journal of Human Genetics
American Journal of Human Genetics, 2020, 107, pp.1170-1177. ⟨10.1016/j.ajhg.2020.11.001⟩
American journal of human genetics, 107(6), 1170-1177. Cell Press

مصطلحات موضوعية: 0301 basic medicine, Male, Jumonji Domain-Containing Histone Demethylases, [SDV]Life Sciences [q-bio], Developmental Disabilities, Corpus callosum, Hippocampus, Epigenesis, Genetic, Histones, Mice, 0302 clinical medicine, Neurodevelopmental disorder, Polymicrogyria, Global developmental delay, Agenesis of the corpus callosum, Genetics (clinical), Brain, Magnetic Resonance Imaging, [SDV] Life Sciences [q-bio], intellectual disability, Brain size, Female, dysmorphic hippocampi, Signal Transduction, Heterozygote, heterozygous variant, global developmental delay, Biology, Nervous System Malformations, Methylation, 03 medical and health sciences, Seizures, Report, KDM4B, Genetics, medicine, Animals, Humans, neurodevelopmental disorder, Dentate gyrus, Genetic Variation, JMJD2B, medicine.disease, 030104 developmental biology, agenesis of the corpus callosum, Neuroscience, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, Ventriculomegaly