المؤلفون: Christopher C. Oakes, Elena Mylonas, Yusuke Shiozawa, Lars Bullinger, Matthias Obenaus, Daniel Noerenberg, Mareike Frick, Michaela Schwarz, Matthew J. J. Rose-Zerilli, Kenichi Yoshida, Friederike Christen, Yotaro Ochi, Willy Chan, Frederik Damm, Jaspal Kaeda, Philipp le Coutre, Yuichi Shiraishi, Seishi Ogawa, Thorsten Zenz, Birgit Sawitzki, Kaja Hoyer, Cornelius Hennch

المساهمون: University of Zurich, Damm, Frederik

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Neuroblastoma RAS viral oncogene homolog, Ruxolitinib, Cancer Research, Myeloid, Somatic cell, General Physics and Astronomy, medicine.disease_cause, Somatic evolution in cancer, Biochemistry, Loss of heterozygosity, 0302 clinical medicine, Single-cell analysis, Genotype, Cancer genomics, Medicine, Exome, Prospective Studies, lcsh:Science, Cancer genetics, Genetics, Mutation, Multidisciplinary, Stem Cells, Hematology, Middle Aged, 3100 General Physics and Astronomy, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, KRAS, Single-Cell Analysis, medicine.drug, medicine.medical_specialty, Science, Immunology, 610 Medicine & health, 1600 General Chemistry, Biology, Oncogene Protein p21(ras), General Biochemistry, Genetics and Molecular Biology, Article, Clonal Evolution, Genetic Heterogeneity, 03 medical and health sciences, 1300 General Biochemistry, Genetics and Molecular Biology, Internal medicine, Humans, Myelofibrosis, Allele frequency, Aged, Haematological cancer, Genetic heterogeneity, business.industry, General Chemistry, Cell Biology, medicine.disease, 030104 developmental biology, Tumor progression, Primary Myelofibrosis, 10032 Clinic for Oncology and Hematology, lcsh:Q, business, Follow-Up Studies, 030215 immunology

وصف الملف: s41467-019-13892-x.pdf - application/pdf; application/pdf; text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3708a3b78d2b6ca5768702654f70b0Test
https://doaj.org/article/7e23582169274e9ab60ff7109190fa37Test

المؤلفون: Ulrich Schweizer, Jerome M. Hershman, Josef Köhrle, Theo D. Kim, Doreen Braun, Philipp le Coutre

المصدر: The Journal of Clinical Endocrinology & Metabolism. 97:E100-E105

مصطلحات موضوعية: Monocarboxylic Acid Transporters, Sorafenib, medicine.medical_specialty, Indoles, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Drug Evaluation, Preclinical, Down-Regulation, Transfection, Binding, Competitive, Biochemistry, Piperazines, Iodine Radioisotopes, Dogs, Endocrinology, Internal medicine, Sunitinib, Animals, Humans, Medicine, Pyrroles, Protein Kinase Inhibitors, Cells, Cultured, Monocarboxylate transporter, Clinical Trials as Topic, Triiodothyronine, Symporters, biology, business.industry, Biochemistry (medical), Biological Transport, Protein-Tyrosine Kinases, Dasatinib, Thyroxine, Pyrimidines, Imatinib mesylate, Nilotinib, Benzamides, Imatinib Mesylate, biology.protein, Cancer research, business, Tyrosine kinase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b65588e3f96668384558ac13c44d6eTest
https://doi.org/10.1210/jc.2011-1837Test

المؤلفون: Philipp le Coutre, Petra Reinke, Ralf Trappe, Ruth Neuhaus, Philipp Hemmati, Marc Lalancette, Frauke Ringel, Bernd Dörken, Peter T. Daniel

المصدر: European Journal of Haematology. 84:26-33

مصطلحات موضوعية: medicine.medical_specialty, education.field_of_study, Population, Clone (cell biology), Myeloid leukemia, Chromosomal translocation, Hematology, General Medicine, Biology, Fusion protein, Organ transplantation, Immune system, hemic and lymphatic diseases, Immunology, medicine, education, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f0bb272cdbcbb4f288f165422b120021Test
https://doi.org/10.1111/j.1600-0609.2009.01357.xTest

المؤلفون: Franck E. Nicolini, Gert J. Ossenkoppele, Philipp le Coutre, Ariful Haque, Kapil N. Bhalla, Mark R. Litzow, Francesca Palandri, Yaping Shou, Stephen G. O'Brien, Giuliana Alimena, Hagop M. Kantarjian, Norbert Gattermann, Aaron Weitzman, Francis J. Giles, Francisco Cervantes, Andreas Hochhaus, Ravi Bhatia, Debra Resta

المصدر: Blood. 110:3540-3546

مصطلحات موضوعية: Male, Fusion Proteins, bcr-abl, THERAPY, Biochemistry, Gastroenterology, DISEASE, Piperazines, Tyrosine-kinase inhibitor, hemic and lymphatic diseases, CML, Aged, 80 and over, DASATINIB, Hematology, Middle Aged, Protein-Tyrosine Kinases, Bcr-Abl tyrosine-kinase inhibitor, CYTOGENETIC RESPONSES, Treatment Outcome, CHRONIC MYELOID-LEUKEMIA, IN-VITRO ACTIVITY, CYTOGENETIC RESPONSES, BLAST CRISIS, THERAPY, DASATINIB, MESYLATE, BIOLOGY, DISEASE, CML, Benzamides, Imatinib Mesylate, Female, Bosutinib, medicine.drug, Adult, medicine.medical_specialty, medicine.drug_class, IN-VITRO ACTIVITY, Immunology, MESYLATE, BIOLOGY, Antineoplastic Agents, Biology, Philadelphia chromosome, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Internal medicine, medicine, Humans, CHRONIC MYELOID-LEUKEMIA, neoplasms, Aged, Imatinib, BLAST CRISIS, Cell Biology, medicine.disease, Pyrimidines, Imatinib mesylate, Nilotinib, Drug Resistance, Neoplasm, Chronic Disease, Cancer research, Chronic myelogenous leukemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a3823c4d225e024dc0c24326ba9e60Test
https://doi.org/10.1182/blood-2007-03-080689Test

المؤلفون: Philipp le Coutre, Lars Morawietz, Axel Ladhoff, Detlef Katenkamp, Iver Petersen, Cornelius Kuhnen

المصدر: Virchows Archiv. 447:990-995

مصطلحات موضوعية: Male, Pathology, medicine.medical_specialty, Lung Neoplasms, Fibrosarcoma, Calponin, Vimentin, Pathology and Forensic Medicine, Diagnosis, Differential, Carcinoma, medicine, Humans, Neoplasm, Pneumonectomy, Molecular Biology, Myosarcoma, Lung, biology, Nucleic Acid Hybridization, Sarcoma, Cell Biology, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, Primary tumor, medicine.anatomical_structure, biology.protein, Differential diagnosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4085c43a10497b3fac987dcf37c4b0Test
https://doi.org/10.1007/s00428-005-0043-yTest

المؤلفون: Bert Hildebrandt, Matthias Holdhoff, Hanno Riess, Richard A. Van Etten, Bernd Dörken, Christine Appelt, Il-Kang Na, Christian Schmidt, Regina Scholz, Andreas Jordan, Karl Anton Kreuzer, Philipp le Coutre

المصدر: Blood Cells, Molecules, and Diseases. 34:181-185

مصطلحات موضوعية: Radiation-Sensitizing Agents, Radiosensitizer, Cell Survival, medicine.medical_treatment, Breast Neoplasms, Pharmacology, Piperazines, chemistry.chemical_compound, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Humans, Receptors, Platelet-Derived Growth Factor, Autocrine signalling, neoplasms, Molecular Biology, biology, business.industry, Growth factor, Dose-Response Relationship, Radiation, Imatinib, Tyrosine phosphorylation, Cell Biology, Hematology, Pyrimidines, Imatinib mesylate, chemistry, Benzamides, Colonic Neoplasms, Imatinib Mesylate, Cancer research, biology.protein, Molecular Medicine, Female, Glioblastoma, business, Tyrosine kinase, Platelet-derived growth factor receptor, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b11ac0f3e9f79d12fadf8b72a83df4Test
https://doi.org/10.1016/j.bcmd.2004.11.006Test

المؤلفون: Christine Appelt, Gerhard Ehninger, Carlo Gambacorti-Passerini, Christian W. Müller, Joachim Lupberger, Il-Kang Na, Ragnhild Bonnet, Michaela Schwarz, Karl Anton Kreuzer, Philipp le Coutre, Uwe Platzbecker, Matthias Holdhoff, Christian Schmidt

المصدر: Blood Cells, Molecules, and Diseases. 28:75-85

مصطلحات موضوعية: Male, Time Factors, medicine.drug_class, Orosomucoid, Biology, Piperazines, Tyrosine-kinase inhibitor, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Humans, RNA, Messenger, Kinase activity, Molecular Biology, Aged, ABL, breakpoint cluster region, Myeloid leukemia, Cell Biology, Hematology, Middle Aged, Prognosis, medicine.disease, Leukemia, Pyrimidines, Imatinib mesylate, Case-Control Studies, Benzamides, Disease Progression, Imatinib Mesylate, Cancer research, biology.protein, Molecular Medicine, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29f2f924e3c2e68f78ecb179d9b1728Test
https://doi.org/10.1006/bcmd.2002.0493Test

المؤلفون: Christine Appelt, Philipp le Coutre, Antje Saborowski, Il-Kang Na, Karl-Anton Kreuzer, Christian Schmidt, Joachim Lupberger

المصدر: British Journal of Haematology. 114:313-318

مصطلحات موضوعية: Messenger RNA, ABL, Myeloid, urogenital system, breakpoint cluster region, Hematology, Biology, urologic and male genital diseases, medicine.disease, Minimal residual disease, Molecular biology, female genital diseases and pregnancy complications, Reverse transcription polymerase chain reaction, Leukemia, medicine.anatomical_structure, hemic and lymphatic diseases, Gene expression, medicine, Cancer research

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d85327716701b975bd6f316ebd8ba647Test
https://doi.org/10.1046/j.1365-2141.2001.02912.xTest

المؤلفون: Francesca Rossi, Elisabetta Gianazza, Enrico Pogliani, Philipp le Coutre, Josef Brueggen, Robert Cozens, Massimo Zucchetti, Rossella Barni, Gonçalo Cabrita, Gianmarco Corneo, Franca Formelli, Pietro Pioltelli, Carlo Gambacorti-Passerini, Loredana Cleris, Maurizio D'Incalci

المصدر: Journal of the National Cancer Institute. 92:1641-1650

مصطلحات موضوعية: Cancer Research, Time Factors, Blotting, Western, Fusion Proteins, bcr-abl, Mice, Nude, Antineoplastic Agents, Orosomucoid, Pharmacology, Piperazines, Mice, In vivo, Settore BIO/10 - Biochimica, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Tumor Cells, Cultured, Animals, Humans, Enzyme Inhibitors, Phosphorylation, Kinase activity, ABL, biology, breakpoint cluster region, Drug Synergism, Protein-Tyrosine Kinases, In vitro, Erythromycin, Pyrimidines, Imatinib mesylate, Oncology, Drug Resistance, Neoplasm, Benzamides, Immunology, Imatinib Mesylate, biology.protein, Drug Therapy, Combination, Female, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db046324a0aec639a5382061cc9172dTest
https://doi.org/10.1093/jnci/92.20.1641Test

المؤلفون: Roberto Giardini, Loredana Cleris, Franca Formelli, Elisabeth Buchdunger, Carlo Gambacorti-Passerini, Luca Mologni, Edoardo Marchesi, Philipp le Coutre

المصدر: Scopus-Elsevier

مصطلحات موضوعية: Cancer Research, Fusion Proteins, bcr-abl, Antineoplastic Agents, Biology, Piperazines, Mice, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Acute lymphocytic leukemia, Tumor Cells, Cultured, medicine, Animals, Humans, Enzyme Inhibitors, Kinase activity, Leukemia, Experimental, ABL, breakpoint cluster region, Myeloid leukemia, Protein-Tyrosine Kinases, medicine.disease, Leukemia, Pyrimidines, Imatinib mesylate, Oncology, Benzamides, Imatinib Mesylate, Cancer research, Tyrosine kinase, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0150ccb0977b7163664482f702e0c22bTest
https://doi.org/10.1093/jnci/91.2.163Test