المؤلفون: Jie Li, Xiaoyun Zhu, Jie Zou, Hao Zhang, Dejuan Xiang, Ling-Yi Kong, Zhigui Su, Yanqiu Zhang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1578-1591 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Hepatocellular carcinoma, NASH, non-alcoholic steatohepatitis, Proliferation, Fructose 1,6-bisphosphatase, RM1-950, Carbohydrate metabolism, LIX1L, Limb and CNS expressed 1 like, Metastasis, 03 medical and health sciences, 0302 clinical medicine, FBP1, CCl4, carbon tetrachloride, miRNA, microRNA, medicine, shRNA, short-hairpin RNA, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, Glucose metabolism, 0303 health sciences, Gene knockdown, ECAR, extracellular acidification rate, biology, business.industry, Gluconeogenesis, Cell migration, medicine.disease, Seq, sequencing, LIX1L, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Original Article, miR-21-3p, Therapeutics. Pharmacology, HCC, hepatocellular carcinoma, Liver cancer, business, EMT, epithelial–mesenchymal transition, FBP1, fructose-1,6-bisphosphatase 1, DEN, diethylnitrosamine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c970bf879a240521753514a3be8c82cTest
https://doi.org/10.1016/j.apsb.2021.02.005Test

المؤلفون: GwangPyo Ko, Won Kim, Seoyeon Park, Bon Jeong Ku, Sae Kyung Joo, Hyun Ju You, Jiyeon Si, Giljae Lee, Dong Hyeon Lee

المصدر: Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 5920-5930 (2021)
Computational and Structural Biotechnology Journal

مصطلحات موضوعية: endocrine system diseases, BMI, body mass index, Disease, Gut flora, Biochemistry, Gastroenterology, Structural Biology, LDL, low-density lipoprotein, Enterotype, biology, NASH-CRN, non-alcoholic steatohepatitis clinical research network, Fatty liver, Computer Science Applications, Cohort, LPS, lipopolysaccharide, Research Article, PICRUSt2, phylogenetic investigation of communities by reconstruction of unobserved states 2, Biotechnology, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, FDR, false discovery rate, NASH, non-alcoholic steatohepatitis, Biophysics, HbA1c, glycosylated hemoglobin, digestive system, MaAsLin2, microbiome multivariable association with linear models 2, Non-alcoholic fatty liver disease (NAFLD), ALT, alanine aminotransferase, Diabetes mellitus, Internal medicine, T2D, type 2 diabetes mellitus, Type 2 diabetes mellitus, Genetics, medicine, NAFL, non-alcoholic fatty liver, Microbiome, FBS, fasting blood sugar, ComputingMethodologies_COMPUTERGRAPHICS, Gut microbiome, business.industry, Type 2 Diabetes Mellitus, nutritional and metabolic diseases, Biomarker, medicine.disease, biology.organism_classification, digestive system diseases, business, FLI, fatty liver index, TP248.13-248.65

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f954c67889fd6d23e7de29c2b7336727Test
http://www.sciencedirect.com/science/article/pii/S2001037021004542Test

المؤلفون: Masaru Ishii, Junichi Kikuta, Atsunori Tsuchiya, Masaaki Takamura, Kenji Nakajima, Hara Yukio, Masahiro Ogawa, Suguru Takeuchi, Shunsuke Nojiri, Yuichi Kojima, Junji Yamashita, Shuji Terai, Takayuki Watanabe

المصدر: Regenerative Therapy, Vol 11, Iss, Pp 269-281 (2019)
Regenerative Therapy

مصطلحات موضوعية: 0301 basic medicine, Cirrhosis, ALP, Alkaline phosphatase, Adipose tissue, PGE2, Prostaglandin E2, Pharmacology, medicine.disease_cause, Prostaglandin E synthase, SOD, Superoxide dismutase, Cell therapy, hypoMSCs, MSCs cultured under hypoxic oxygen (5% O2) conditions, 0302 clinical medicine, norMSCs, MSCs cultured under normal oxygen (21% O2) conditions, Fibrosis, CAGE, Cap analysis of gene expression, Prostaglandin E2, LPS, Lipopolysaccharide, lcsh:R5-920, biology, HHSteC, Human Hepatic Stellate Cells, Chemistry, lcsh:Cytology, 8-OHdG, DNA 8-hydroxy-2’-deoxyguanosine, ALB, Albumin, id-BMM, Induced Bone Marrow Derived Macrophage, Original Article, PGE2, lcsh:Medicine (General), medicine.drug, T-Bil, Total bilirubin, Biomedical Engineering, Biomaterials, 03 medical and health sciences, ECM, Extracellular matrix, Hypoxic condition, medicine, lcsh:QH573-671, MDA, Malondialdehyde, LC, Liver cirrhosis, NASH, Non-alcoholic steatohepatitis, miR210, Mesenchymal stem cell, ALT, Alanine aminotransferase, MSCs, Mesenchymal stem cells, medicine.disease, 030104 developmental biology, Liver cirrhosis, biology.protein, Mesenchymal stem cells, PCR, Polymerase chain reaction, CCl4, Carbon tetrachloride, 030217 neurology & neurosurgery, Oxidative stress, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796000c604663d3d982bebac495f5eedTest
http://www.sciencedirect.com/science/article/pii/S2352320419300811Test

المؤلفون: Hans-Peter Hammes, Elena Heidenreich, Peter P. Nawroth, Martina U. Muckenthaler, Sandro Altamura, Thomas Fleming, Andrea Schlotterer, Katja Müdder, Ruiyue Qiu

المصدر: Molecular Metabolism, Vol 51, Iss, Pp 101235-(2021)
Molecular Metabolism

مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, DR, diabetic retinopathy, Hepcidin, medicine.disease_cause, Mice, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, MetS, Metabolic Syndrome, Internal medicine, biology, Fpn, Ferroportin, Fatty liver, Liver, DIOS, dysmetabolic iron overload syndrome, CRP, C-reactive protein, Receptors, Leptin, HH, hereditary hemochromatosis, Original Article, IRP, Iron Regulatory Protein, medicine.medical_specialty, Iron Overload, Iron, 030209 endocrinology & metabolism, Mice, Transgenic, IR, Insulin Resistance, SEM, standard error of the mean, 03 medical and health sciences, Insulin resistance, ROS, reactive oxygen species, NASH, Non Alcoholic Steatohepatitis, NAFLD, medicine, Animals, Humans, Molecular Biology, business.industry, NTBI, Non Transferrin Bound Iron, Cell Biology, medicine.disease, RC31-1245, IRS1, Db/db Mouse, Disease Models, Animal, Oxidative Stress, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, NAFLD, Non Alcoholic Fatty Liver Disease, Lipid Peroxidation, Steatosis, Metabolic syndrome, business, Oxidative stress, IRE, Iron Responsive Element, T2DM, Type 2 Diabetes Mellitus

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::746ad7abfa625d87337f2502f8e59462Test
http://www.sciencedirect.com/science/article/pii/S2212877821000806Test

المؤلفون: Jonatan I. Bagger, Tina Vilsbøll, Filip K. Knop, Benjamin Lelouvier, Malte P. Suppli, Charlotte Strandberg, Amandine Broha, Mia Demant, Merete J Kønig, Asger Lund

المصدر: JHEP Reports, Vol 3, Iss 4, Pp 100299-(2021)
JHEP Reports
Suppli, M P, Bagger, J I, Lelouvier, B, Broha, A, Demant, M, Kønig, M J, Strandberg, C, Lund, A, Vilsbøll, T & Knop, F K 2021, ' Hepatic microbiome in healthy lean and obese humans ', JHEP Reports, vol. 3, no. 4, 100299 . https://doi.org/10.1016/j.jhepr.2021.100299Test

مصطلحات موضوعية: NAFLD, non-alcoholic fatty liver disease, NASH, non-alcoholic steatohepatitis, Physiology, RC799-869, Gut flora, rDNA, ribosomal DNA, Liver disease, Internal Medicine, medicine, OTU, operational taxonomic unit, Immunology and Allergy, Microbiome, Obesity, Hepatology, biology, business.industry, Fatty liver, Gastroenterology, Diseases of the digestive system. Gastroenterology, medicine.disease, biology.organism_classification, LEfSe, linear discriminant analysis effect size, Metabolic syndrome, Real-time polymerase chain reaction, qPCR, quantitative polymerase chain reaction, HbA1c, glycated haemoglobin, Steatosis, business, Dysbiosis, FLI, fatty liver index, Research Article, Non-alcoholic fatty liver disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23eee827bacdf1b0e217e24af3bd81a5Test
http://www.sciencedirect.com/science/article/pii/S2589555921000756Test

المؤلفون: N. Thao N. Galvan, Mercedes Barzi, John A. Goss, William R. Lagor, David D. Moore, Adam Dean, Neil J. McKenna, Pavel Sumazin, Barry Zorman, Diane Yang, Beatrice Bissig-Choisat, Karl-Dimiter Bissig, Xavier Legras, David E. Cohen, Robert Brian York, Malgorzata Borowiak, Michele Alves-Bezerra, Scott A. Ochsner

المصدر: JHEP reports : innovation in hepatology, vol 3, iss 3
JHEP Reports
JHEP Reports, Vol 3, Iss 3, Pp 100281-(2021)

مصطلحات موضوعية: phosphatidylinositol, Cirrhosis, Steatosis, ALT, hexosylceramide, Humanised mice, SREBP, sterol regulatory element-binding protein, PI, RC799-869, CMHs, chimeric mouse hepatocytes, 0302 clinical medicine, GGT, gamma-glutamyl transpeptidase, aspartate aminotransferase, HCC, gamma-glutamyl transpeptidase, chemistry.chemical_classification, 0303 health sciences, education.field_of_study, Western-type diet, Gastroenterology, NASH, CHHs, Diseases of the digestive system. Gastroenterology, 3. Good health, confidence transcript, HCT, cholesteryl ester, human albumin, DCER, dihydroceramide, 030211 gastroenterology & hepatology, PC, non-alcoholic steatohepatitis, PE, transgene-free Il2rg-/-/Rag2-/-/Fah, free fatty acid, LPE, lysophosphatidylethanolamine, DCER, NASH, non-alcoholic steatohepatitis, HCER, hexosylceramide, NC, normal chow, TIRF, PE, phosphatidylethanolamine, nitisinone, lysophosphatidylethanolamine, 03 medical and health sciences, dihydroceramide, Human disease modelling, NAFLD, FFA, free fatty acid, LCER, DEG, MUFA, education, phosphatidylcholine, chimeric mouse hepatocytes, FAH, SM, sphingomyelin, ALP, alkaline phosphatase, FA, fatty acid, NTBC, Fatty acid, medicine.disease, differentially expressed gene, lactosylceramide, PNPLA3, patatin-like-phospholipase domain-containing protein 3, Lipid metabolism, chemistry, fatty acid, PUFA, hALB, human albumin, TIRF, transgene-free Il2rg-/-/Rag2-/-/Fah, AST, aspartate aminotransferase, CT, confidence transcript, PC, phosphatidylcholine, monounsaturated fatty acid, DEG, differentially expressed gene, MUFA, monounsaturated fatty acid, Immunology and Allergy, MAG, monoacylglycerol, PUFA, polyunsaturated free FA, CE, cholesteryl ester, CER, diacylglycerol, FAH, fumarylacetoacetate hydrolase, Fatty liver, SM, chimeric human hepatocytes, hepatocellular carcinoma, CBPEGs, cholesterol biosynthesis pathway enzyme genes, CE, MAG, LPC, patatin-like-phospholipase domain-containing protein 3, triacylglycerol, LPE, alkaline phosphatase, sterol regulatory element-binding protein, Polyunsaturated fatty acid, Research Article, CT, NAFLD, non-alcoholic fatty liver disease, FA, HCER, TAG, triacylglycerol, fumarylacetoacetate hydrolase, monoacylglycerol, alanine aminotransferase, Population, cholesterol biosynthesis pathway enzyme genes, Biology, SREBP, PI, phosphatidylinositol, sphingomyelin, lysophosphatidylcholine, WD, ALT, alanine aminotransferase, high confidence transcriptional target, Internal Medicine, medicine, CBPEGs, ceramide, hALB, LCER, lactosylceramide, normal chow, AST, polyunsaturated free FA, WD, Western-type diet, PNPLA3, 030304 developmental biology, Hepatitis, LPC, lysophosphatidylcholine, Hepatology, DAG, non-alcoholic fatty liver disease, NTBC, nitisinone, CMHs, GGT, HCT, high confidence transcriptional target, phosphatidylethanolamine, TAG, Cancer research, CHHs, chimeric human hepatocytes, ALP, Liver function, NC, CER, ceramide, HCC, hepatocellular carcinoma, FFA, DAG, diacylglycerol, Non-alcoholic fatty liver disease

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b0393a5555874a5526c491b8421dfdTest
https://escholarship.org/uc/item/2hg8h2x9Test

المؤلفون: Ellie Northall, Banumathi K. Cole, John E. Reardon, Brian R. Wamhoff, Matthew W. Olson, Stephen A. Hoang, Kae Matsuda, Ulrich L. Günther, Mark J. Lawson, Ryan E. Feaver, Jason Pickens, Patricia F. Lalor, Raquel Saborano, Robert A. Figler, Hiroaki Yashiro, Derek M. Erion, Hitomi Ogino, Emma L. Shepherd, Gideon M. Hirschfield, Nobuhiro Nishigaki

المصدر: JHEP Reports, Vol 3, Iss 2, Pp 100217-(2021)
JHEP Reports

مصطلحات موضوعية: ALD, alcohol-related cirrhosis, IGF, insulin-like growth factor, PDGF, platelet-derived growth factor, chemistry.chemical_compound, Fibrosis, AST, aspartate transaminase, Immunology and Allergy, Glycolysis, Liver injury, G/F, glucose/fructose, biology, TG, triglyceride, Fatty liver, Gastroenterology, NASH, HSQC, heteronuclear single quantum coherence, CT, computed tomography, aLMF, activated liver myofibroblasts, HSCs, hepatic stellate cells, Research Article, medicine.medical_specialty, NAFLD, non-alcoholic fatty liver disease, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, FIB4, fibrosis-4, DNL, de novo lipogenesis, Fructose, Internal medicine, NAFLD, Internal Medicine, medicine, TGFB, transforming growth factor beta, lcsh:RC799-869, APRI, AST to Platelet Ratio Index, NPCs, non-parenchymal cells, KO, knockout, Hepatology, business.industry, medicine.disease, WT, wild-type, KHK, ketohexokinase, HSECs, hepatic sinusoidal endothelial cells, Treatment, Endocrinology, PSC, primary sclerosing cholangitis, Metabolism, chemistry, Alanine transaminase, Hepatic stellate cell, biology.protein, BSA, bovine serum albumin, TIMP-1, Tissue Inhibitor of Matrix metalloproteinase-1, lcsh:Diseases of the digestive system. Gastroenterology, PBC, primary biliary cholangitis, Steatosis, business, BEC, biliary epithelial cells, LGLI, low glucose and insulin

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e901d5e74295d49cc1586ef5be254eTest
http://www.sciencedirect.com/science/article/pii/S2589555920301518Test

المؤلفون: Sheila Maestro, Gloria González-Aseguinolaza, Rafael Aldabe, Nicholas D. Weber, Nerea Zabaleta

المصدر: JHEP Reports

مصطلحات موضوعية: MPS type VII, MPSVII, S/MAR, scaffold matrix attachment regions, PB, piggyBac, gene addition, GalNAc, N-acetyl-D-galactosamine, UCD, urea cycle disorders, Genetic enhancement, medicine.medical_treatment, efficacy, MMA, methylmalonic acidemia, Review, Liver transplantation, medicine.disease_cause, MPS, mucopolysaccharidosis, immune response, IDS, iduronate 2-sulfatase, lncRNA, long non-coding RNA, gene silencing, GSD1a, glycogen storage disorder 1a, AAV, adeno-associated virus, ASOs, antisense oligonucleotides, Genome editing, AHP, acute hepatic porphyrias, HT, hereditary tyrosinemia, IMLD, inherited metabolic liver diseases, PFIC3, progressive familial cholestasis type 3, Immunology and Allergy, NHPs, non-human primates, CRISPR/Cas9, CRISPR associated protein 9, GO, glycolate oxidase, HemA/B, haemophilia A/B, Adeno-associated virus, HDR, homology-directed repair, Transcription activator-like effector nuclease, LNP, Lipid nanoparticles, siRNA, small-interfering RNA, MPR, metabolic pathway reprograming, LDH, lactate dehydrogenase, PH1, Primary hyperoxaluria type 1, gene editing, SRT, substrate reduction therapy, Gastroenterology, Ad, adenovirus, AAT, α1-antitrypsin, PA, propionic acidemia, dCas9, dead Cas9, ERT, enzyme replacement therapy, HDAd, helper-dependent adenovirus, CRISPR, clustered regularly interspaced short palindromic repeats, SB, Sleeping Beauty, LDLR, low-density lipoprotein receptor, MPS type I, MPSI, hepatocytes, OTC, ornithine transcarbamylase, APCs, antigen-presenting cells, DSBs, double-strand breaks, viral vectors, LV, lentivirus, AIP, acute intermittent porphyria, NASH, non-alcoholic steatohepatitis, GT, gene therapy, PKU, phenylketonuria, Computational biology, Gene delivery, Biology, FH, familial hypercholesterolemia, Viral vector, ITR, inverted terminal repetition, ZFN, zinc finger nucleases, GUSB, β-glucuronidase, Internal Medicine, medicine, OLT, orthotopic liver transplantation, Gene silencing, miRNAs, microRNAs, ASGPR, asialoglycoprotein receptor, ALAS1, aminolevulic synthase 1, TALEN, transcription activator-like effector nucleases, CBS, cystathionine β-synthase, PEG, polyethylene glycol, PEI, polyethyleneimine, TTR, transthyretin, Hepatology, IDUA, α-L-iduronidase, toxicity, ASGCT, American Society of Gene and Cell Therapy, CN, Crigel-Najjar, STK25, serine/threonine protein kinase 25, VLDLR, very-low-density lipoprotein receptor, WD, Wilson’s disease, FSP27, fat-specific protein 27, NHEJ, non-homologous end joining, Non-viral vectors, LTR, long terminal repeat, apoB/E, apolipoprotein B/E, RV, retrovirus, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cc33bd8f559ae9ccb64e180a7a274aTest
http://europepmc.org/articles/PMC8203845Test

المؤلفون: Julie Rodriguez, Nathalie M. Delzenne, Christelle Knudsen, Audrey M. Neyrinck, Martin Beaumont, Laure B. Bindels

المساهمون: UCL - SSS/LDRI - Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain = Catholic University of Louvain (UCL), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), École nationale supérieure agronomique de Toulouse [ENSAT]-Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Wallonia (FOOD4GUT project) 1318148 / EU 613979 MyNewGut FP7-609398

المصدر: The Proceedings of the Nutrition Society, Vol. 78, no. 3, p. 319-328 (2019)
Proceedings of the Nutrition Society
Proceedings of the Nutrition Society, Cambridge University Press (CUP), 2019, 78 (3), pp.319-328. ⟨10.1017/S0029665118002756⟩

مصطلحات موضوعية: GLP glucagon-like peptide, 0301 basic medicine, non-alcoholic fatty liver desease, Medicine (miscellaneous), Gut flora, Bioinformatics, Mice, GPR G protein-coupled receptors, 0302 clinical medicine, NASH non-alcoholic steatohepatitis, Non-alcoholic Fatty Liver Disease, Nutrition and Dietetics, Fatty liver, 3. Good health, Liver, NAFLD non-alcoholic fatty liver disease, prebiotic, ALT alanine aminotransferase, 030211 gastroenterology & hepatology, medicine.symptom, ITF inulin-type fructans, [SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT], Inflammation, Gut microbiota, Biology, digestive system, 03 medical and health sciences, BA bile acid, medicine, Animals, Humans, gut microbiota, Host (biology), Probiotics, FXR farnesoid X receptor, AST aspartate aminotransferase, Metabolism, medicine.disease, biology.organism_classification, Obesity, Gastrointestinal Microbiome, Disease Models, Animal, Prebiotics, 030104 developmental biology, AhR aryl hydrocarbon receptor, inflammation, LPS lipopolysaccharides, Farnesoid X receptor, Energy Metabolism, Function (biology), Non-alcoholic fatty liver disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e56d9d5d0ddd04fa33e558922e0d67Test
https://doi.org/10.1017/s0029665118002756Test

المؤلفون: Hilde Herrema, Torsten P. M. Scheithauer, Albert K. Groen, Max Nieuwdorp, Jeffrey Kroon, Abraham S. Meijnikman

المصدر: JHEP Reports

مصطلحات موضوعية: Senescence, obesity, NAFLD, non-alcoholic fatty liver disease, MiDAS, mitochondrial dysfunction-associated senescence, TGFβ, transforming growth factor-β, NASH, non-alcoholic steatohepatitis, LSEC, liver sinusoidal endothelial cell, Senescence-associated beta-galactosidase, MCP1/CCL2, monocyte chemoattractant protein-1, Review, SASP, senescence-associated secretory phenotype, Biology, DDR, DNA damage response, Proinflammatory cytokine, ROS, reactive oxygen species, Cyclin-dependent kinase, Rb, retinoblastoma factor, Internal Medicine, medicine, Immunology and Allergy, cellular senescence, KC, Kupffer cell, NAFL, non-alcoholic fatty liver, TNFα, tumour necrosis factor-α, Senolytic, ATM, ataxia telangiectasia mutated, Hepatology, SA-β gal, senescence-associated beta-galactosidase, Fatty liver, Gastroenterology, non-alcoholic fatty liver disease, C/EBPα, CCAAT- enhancer-binding protein, medicine.disease, CDK, cyclin dependent kinase, Telomere, IL-, interleukin, senolytics, Cancer research, biology.protein, non-alcoholic steatohepatitis, SCAP, senescence-associated antiapoptotic pathways, Steatohepatitis, FFAs, free fatty acids, qPCR, quantitative PCR, HCC, hepatocellular carcinoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49cf6b852a0781adc214c7756b7b84c9Test
https://pubmed.ncbi.nlm.nih.gov/34113839Test