نتائج البحث

31

Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use

المؤلفون: Nick Devoogdt, Sandrina Martens, Marleen Keyaerts, Sam Massa, Yannick De Vlaeminck, Karine Breckpot, Katty Zeven, Cleo Goyvaerts, Geert Raes, Quentin Lecocq

المساهمون: Basic (bio-) Medical Sciences, Faculty of Medicine and Pharmacy, Supporting clinical sciences, Laboratory for Medical and Molecular Oncology, Experimental Pathology, Pathology/molecular and cellular medicine, Department of Bio-engineering Sciences, Cellular and Molecular Immunology, Medical Imaging, Laboratory of Molecullar and Cellular Therapy, Nuclear Medicine, Translational Imaging Research Alliance

المصدر: Biomolecules, Vol 9, Iss 10, p 548 (2019)
Biomolecules
Volume 9
Issue 10

مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, single domain antibody, lag-3, lcsh:QR1-502, Single-photon emission computed tomography, Biochemistry, Article, Antibodies, lcsh:Microbiology, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Antigens, CD, In vivo, Animals, Medicine, cancer, Molecular Biology, immune checkpoint, Camelidae, nuclear imaging, biology, medicine.diagnostic_test, business.industry, Cancer, Single-Domain Antibodies, medicine.disease, molecular imaging, Lymphocyte Activation Gene 3 Protein, Recombinant Proteins, Immune checkpoint, nanobody, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, Antibody, Molecular imaging, immune cell, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c931ad1f7671a1bebb10f62f89270d23Test
https://www.mdpi.com/2218-273X/9/10/548Test

32

Blockade of PD-1 and LAG-3 Immune Checkpoints Combined with Vaccination Restores the Function of Antiviral Tissue-Resident CD8+ TRM Cells and Reduces Ocular Herpes Simplex Infection and Disease in HLA Transgenic Rabbits

المؤلفون: Nisha R Dhanushkodi, Soumyabrata Roy, Vivianna Nguyen, Roger Geertsema, Lbachir BenMohamed, Nuha I. Alomari, Ruchi Srivastava, Swayam Prakash, Cynthia Lam, Angela M. Nguyen, Wasay R. Warsi, Pierre-Gregoire A Coulon, Stephanie Salazar, Elyssa Gorospe

المساهمون: Jung, Jae U

المصدر: Journal of virology, vol 93, iss 18

مصطلحات موضوعية: Male, Programmed Cell Death 1 Receptor, Epitopes, T-Lymphocyte, Herpesvirus 1, Human, CD8-Positive T-Lymphocytes, medicine.disease_cause, Medical and Health Sciences, B7-H1 Antigen, ocular, CD8(+) T cell, Cornea, Epitopes, 0302 clinical medicine, HLA Antigens, Histocompatibility Antigens, vaccine, PD-1, Cytotoxic T cell, 2.1 Biological and endogenous factors, Aetiology, 0303 health sciences, Vaccination, herpes, Herpes Simplex Virus Vaccines, Middle Aged, Biological Sciences, protection, Lymphocyte Activation Gene 3 Protein, HSV-1, CD, Virus Shedding, medicine.anatomical_structure, Infectious Diseases, Trigeminal Ganglion, Female, Rabbits, CD8+ T cell, Infection, Human, Adult, T cell, Immunology, rabbit, Human leukocyte antigen, Biology, Microbiology, Ocular herpes, Vaccine Related, 03 medical and health sciences, Immune system, Rare Diseases, Antigens, CD, LAG-3, Virology, HLA-A2 Antigen, medicine, Animals, Humans, Antigens, Eye Disease and Disorders of Vision, 030304 developmental biology, disease, Agricultural and Veterinary Sciences, Herpesvirus 1, Prevention, Histocompatibility Antigens Class II, medicine.disease, Immune checkpoint, Blockade, Herpes simplex virus, Good Health and Well Being, T-Lymphocyte, Insect Science, Pathogenesis and Immunity, Sexually Transmitted Infections, Immunization, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237cff6702e212cf24e4cad714ed9ab6Test
https://escholarship.org/uc/item/7c33m4nxTest

33

Building a Bridge between Chemotherapy and Immunotherapy in Malignant Pleural Mesothelioma: Investigating the Effect of Chemotherapy on Immune Checkpoint Expression

المؤلفون: Jonas Van Audenaerde, Jinthe Van Loenhout, Julie Jacobs, Patrick Pauwels, Elly Marcq, Jorrit De Waele, Jan P. van Meerbeeck, Glenn Cavents, Evelien Smits

المصدر: International Journal of Molecular Sciences
Volume 20
Issue 17
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4182 (2019)
International journal of molecular sciences

مصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, medicine.medical_treatment, MPM, Gene Expression, chemotherapy, lcsh:Chemistry, 0302 clinical medicine, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, PD-1, Mesothelioma, Molecular Targeted Therapy, lcsh:QH301-705.5, Spectroscopy, biology, General Medicine, Combined Modality Therapy, Computer Science Applications, Chemistry, Pemetrexed, 030220 oncology & carcinogenesis, mesothelioma, Immunotherapy, medicine.drug, PD-L1, TIM-3, Antineoplastic Agents, Catalysis, Article, Inorganic Chemistry, Immunomodulation, 03 medical and health sciences, LAG-3, Cell Line, Tumor, medicine, Biomarkers, Tumor, Animals, Humans, tumor microenvironment, Physical and Theoretical Chemistry, Biology, Molecular Biology, Cisplatin, Chemotherapy, business.industry, Organic Chemistry, Mesothelioma, Malignant, immune checkpoints, medicine.disease, Immune checkpoint, Oxaliplatin, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, biology.protein, Cancer research, Human medicine, business

وصف الملف: application/pdf; pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1867699192e142b0bd4c1411738ddbcTest

34

Combination immunotherapy strategies in advanced non-small cell lung cancer (NSCLC): Does biological rationale meet clinical needs?

المؤلفون: Alberto Pavan, Filippo de Marinis, Laura Bonanno, Antonio Passaro, Ilaria Attili, Pierfranco Conte

المصدر: Critical Reviews in Oncology/Hematology. 119:30-39

مصطلحات موضوعية: PD-L1, 0301 basic medicine, Oncology, medicine.medical_specialty, Lung Neoplasms, medicine.medical_treatment, Programmed Cell Death 1 Receptor, non-small cell lung cancer (NSCLC), Disease, B7-H1 Antigen, IDO, 03 medical and health sciences, 0302 clinical medicine, LAG-3, Carcinoma, Non-Small-Cell Lung, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Animals, Humans, Medicine, CTLA-4 Antigen, Lung cancer, Antiangiogenic treatment, CTLA-4, Combination treatment, Immune checkpoint, Tumor microenvironment, biology, business.industry, Antibodies, Monoclonal, Hematology, medicine.disease, Radiation therapy, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, biology.protein, Tumor Escape, Immunotherapy, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc111800f5ade8f2fadbfbd81d2cc88Test
https://doi.org/10.1016/j.critrevonc.2017.09.007Test

35

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

المساهمون: Lino, Andreia C., Center of Experimental and Molecular Medicine, AII - Inflammatory diseases, Leibniz Association, Saarland University [Saarbrücken], Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Unité de recherche Virologie et Immunologie Moléculaires (VIM (UR 0892)), Institut National de la Recherche Agronomique (INRA), Tokyo Medical and Dental University, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], German Research Center for Environmental Health - Helmholtz Center München (GmbH), Vrije universiteit = Free university of Amsterdam [Amsterdam] (VU), Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Max Planck Institute for Infection Biology (MPIIB), Max-Planck-Gesellschaft, Université Paris Descartes - Paris 5 (UPD5), AXA Chair Translational Immunology, Agence Nationale de la Recherche [ANR-16-CE18-0007-01], Chair of Excellence (Universite Sorbonne Paris Cite), Infect-ERA project ABIR [031A403], Deutsche Forschungsgemeinschaft [TRR130, FI 1238/1-2], JSPS KAKENHI [26293062, 17H05790], German Ministry for Education and Research BMBF [01KU1216F], Vietnam Ministry of Education and Training [322, 911], European Project: 647696,H2020,ERC-2014-CoG,PREG-LAB(2016), VU University Amsterdam, Vrije Universiteit Amsterdam [Amsterdam] (VU), ANR-16-CE18-0007,TCRinMS,manipulation génétique des lymphocytes T régulateurs: un outil thérapeutique dans la sclérose en plaques(2016)

المصدر: Immunity 1 (49), 120-+. (2018)
Immunity
Immunity, 49(1), 120-133.e9. Cell Press
Immunity, Elsevier, 2018, 49 (1), pp.120-+. ⟨10.1016/j.immuni.2018.06.007⟩
Immunity, 2018, 49 (1), pp.120-+. ⟨10.1016/j.immuni.2018.06.007⟩
Immunity 49, 120-133.e9 (2018)

مصطلحات موضوعية: Male, CD4(+) T-CELLS, 0301 basic medicine, natural regulatory plasma cell, CD4-Positive T-Lymphocytes, T-Lymphocytes, [SDV]Life Sciences [q-bio], Receptor expression, interleukin-10, il-10, Gene Expression, n-vivo, Plasma cell, Lymphocyte Activation, T-Lymphocytes, Regulatory, Epigenesis, Genetic, Mice, 0302 clinical medicine, generation, Immunology and Allergy, b-cells, Receptor, transcription factor, Vaccines, checkpoint receptor, Toll-Like Receptors, autoimmunity, Interleukin, differentiation, BCR, Lymphocyte Activation Gene 3 Protein, Up-Regulation, 3. Good health, Cell biology, Interleukin 10, Infectious Diseases, medicine.anatomical_structure, Female, Immunosuppressive Agents, Signal Transduction, Immunology, B-cell receptor, Plasma Cells, B-Lymphocyte Subsets, Receptors, Antigen, B-Cell, Biology, protective immunity i, Article, 03 medical and health sciences, Antigens, CD, LAG-3, TLR, medicine, Animals, B cell, Salmonella Infections, Animal, B cells, B Cells, Bcr, Cd72, Lag-3, Tlr, Checkpoint Receptor, Immune Regulation, Infection, Interleukin-10, Natural Regulatory Plasma Cell, Gene Expression Profiling, gene-expression, immune regulation, infection, 030104 developmental biology, CD72, Memory T cell, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4189f60e46cf0f47dbe490ba6e252140Test
http://prodinra.inra.fr/record/447645Test

36

Lymphocyte‐activation gene‐3, an important immune checkpoint in cancer

المؤلفون: Fred R. Hirsch, Leslie Rozeboom, Caicun Zhou, Christopher J. Rivard, Hui Yu, Ashley Kowalewski, Yayi He, Kim Ellison

المصدر: Cancer Science

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Programmed cell death, soluble LAG‐3, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cell, Gene Expression, Review Article, Biology, B7-H1 Antigen, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, T-Lymphocyte Subsets, Neoplasms, lymphocyte‐activation gene‐3, Drug Discovery, medicine, Animals, Humans, Cytotoxic T cell, CTLA-4 Antigen, Molecular Targeted Therapy, Lung cancer, Review Articles, Antibodies, Monoclonal, Cancer, clinical trial, Cancer checkpoints, General Medicine, Immunotherapy, medicine.disease, Lymphocyte Activation Gene 3 Protein, Immune checkpoint, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Immunology, Cancer research, Disease Susceptibility, immunotherapy, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a16484b5f8de377d927d42c04509e13Test
https://doi.org/10.1111/cas.12986Test

37

Inhibitory mechanisms of LAG-3–dependent T cell suppression

المؤلفون: Daisuke Sugiura, Takumi Maruhashi, Taku Okazaki, Takeo K. Maeda, Il-mi Okazaki

مصطلحات موضوعية: 0301 basic medicine, Co-receptor, T cell, medicine.medical_treatment, T-Lymphocytes, Immunology, Amino Acid Motifs, Inhibitory postsynaptic potential, Lymphocyte Activation, モノクローナル抗体, Biochemistry, 03 medical and health sciences, Mice, Immune system, Cancer immunotherapy, Protein Domains, LAG-3, Antigens, CD, medicine, Cytotoxic T cell, Animals, T細胞抗原受容体, Molecular Biology, Mice, Knockout, 030102 biochemistry & molecular biology, biology, Chemistry, Cell Biology, 免疫補助受容体, Lymphocyte Activation Gene 3 Protein, In vitro, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, biology.protein, 抑制機構, Antibody, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d194ba08735c470a7e38502aaaf55afdTest
https://europepmc.org/articles/PMC6463702Test/

38

TIM-3 expression in breast cancer

المؤلفون: Samantha Burugu, Torsten O. Nielsen, Dongxia Gao, Stephen Chia, Samuel Leung

المصدر: Oncoimmunology
OncoImmunology, Vol 7, Iss 11 (2018)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::618262a4c4686a715f35dc1d32077165Test
http://europepmc.org/articles/PMC6205019Test

39

Targeted Proteomics Reveals Inflammatory Pathways that Classify Immune Dysregulation in Common Variable Immunodeficiency

المؤلفون: Joris M. van Montfrans, Baerbel Keller, Pauline M. Ellerbroek, Annick A. J. M. van de Ven, Julia Drylewicz, Stefan Nierkens, Klaus Warnatz, P. Martin van Hagen, Jaap M van Laar, Roos-Marijn Berbers, Helen L. Leavis, Virgil A. S. H. Dalm

المساهمون: Immunology, Internal Medicine

المصدر: Journal of Clinical Immunology, 41(2), 362-373. Springer New York
Journal of Clinical Immunology
Journal of Clinical Immunology, 41. SPRINGER/PLENUM PUBLISHERS

مصطلحات موضوعية: Adult, Male, Proteomics, Chemokine, LAG3, DISORDERS, medicine.medical_treatment, Common variable immunodeficiency (CVID), Immunology, PROTEIN, chemical and pharmacologic phenomena, INTERSTITIAL LUNG-DISEASE, medicine.disease_cause, Autoimmunity, Cohort Studies, ACTIVATION, Immune system, MARKERS, LAG-3, Immunology and Allergy, Medicine, Humans, Inflammation, Primary immunodeficiency, biology, RECEPTOR, business.industry, Common variable immunodeficiency, Immune dysregulation, Middle Aged, Th1 Cells, medicine.disease, DEFICIENCY, Cytokine, Common Variable Immunodeficiency, biology.protein, T-CELLS, Th17 Cells, Cytokines, Original Article, Female, Chemokines, business, Prediction, Biomarkers, Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19d3ecb85b241cd84dc58061789872d9Test
https://research.rug.nl/en/publications/bd83922a-fae5-44ec-8649-fb3ce7e70a5fTest

40

Manipulation of the Immune System for Cancer Defeat: A Focus on the T Cell Inhibitory Checkpoint Molecules

المؤلفون: Maria Fiammetta Romano, Nunzia Novizio, Simona Romano, Vincenza Vigorito, Anna Rea, Martina Tufano, Salvatore Russo, Paolo D'Arrigo

المساهمون: D'Arrigo, Paolo, Tufano, Martina, Rea, Anna, Vigorito, Vincenza, Novizio, Nunzia, Russo, Salvatore, Romano, Maria Fiammetta, Romano, Simona

المصدر: Current medicinal chemistry. 27(15)

مصطلحات موضوعية: 3-dioxygenase-1, medicine.medical_treatment, T cell, T-Lymphocytes, Programmed Cell Death 1 Receptor, B7 homolog 4 protein (B7-H4), Biology, Biochemistry, Targeted therapy, Immune tolerance, 03 medical and health sciences, 0302 clinical medicine, Immune system, Neoplasms, B7 homolog 3 protein (B7-H3), V-domain Ig suppressor of T cell activation (VISTA), Drug Discovery, medicine, Humans, 2 (IDO), Adenosine A2a receptor (A2aR), 030304 developmental biology, Pharmacology, T cell immunoglobulin and mucin domain 3 (TIM-3), 0303 health sciences, Programmed cell Death 1 (PD-1), Immune-regulatory molecule indoleamine pyrrole-2, Organic Chemistry, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), Cancer, Immunotherapy, medicine.disease, Immune checkpoint, Programmed Death-Ligand 1 (PD-L1), medicine.anatomical_structure, Immunoediting, B and T lymphocyte associated (BTLA), 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Lymphocyte Activation Gene-3 (LAG-3), Biomarkers

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48008a57b35d97e800d73e8c18798a9dTest
https://pubmed.ncbi.nlm.nih.gov/30398102Test

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