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1
المؤلفون: Dillon H. Miles, Ada Chen, Manmohan Reddy Leleti, Divyank Soni, Stephen W Young, Artur K. Mailyan, Kenneth V. Lawson, Stefan G Shaqfeh, Ehesan U. Sharif, Jenna L. Jeffrey, Jesus Banuelos, Xuelei Yan, Samuel L Drew, Kimberline Gerrick, Nigel Walker, Puja Dhanota, Lixia Jin, Jay P. Powers, Elaine Ginn, Guillaume Mata, Kent Wong, Hema Singh, Jeremy Fournier, Joel W. Beatty, Ulrike Schindler, Amber Pham, Matthew J. Walters, Jie Chen, Cesar Meleza, Xiaoning Zhao, Nell Narasappa
المصدر: Journal of Medicinal Chemistry. 65:1418-1444
مصطلحات موضوعية: Male, Pyrazolopyrimidine, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Immune system, Amide, Drug Discovery, Animals, Class Ib Phosphatidylinositol 3-Kinase, Humans, Structure–activity relationship, Potency, Phosphoinositide-3 Kinase Inhibitors, Phosphoinositide 3-kinase, biology, Amides, Phenotype, In vitro, Rats, Molecular Docking Simulation, Pyrimidines, chemistry, Biochemistry, Drug Design, biology.protein, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37aec4464f4375ff8b99d31a40b9e89Test
https://doi.org/10.1021/acs.jmedchem.1c01153Test -
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المؤلفون: Guillaume Mata, Manmohan Reddy Leleti, Stephen W Young, Lixia Jin, Jenna L. Jeffrey, Jeremy Fournier, Ada Chen, Matthew J. Walters, Jay P. Powers, Xiaoning Zhao, Jesus Banuelos, Cesar Meleza, Artur K. Mailyan
المصدر: The FASEB Journal. 34:1-1
مصطلحات موضوعية: Phosphoinositide 3-kinase, biology, Biochemistry, Chemistry, Genetics, biology.protein, Molecular Biology, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::297d3bb3608702ac67455868498bf64bTest
https://doi.org/10.1096/fasebj.2020.34.s1.09720Test -
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المؤلفون: Mark E. T. Penfold, Ronald J. Falk, Juan C. Jaen, Lin Gan, Daniel J. Dairaghi, Bao Lu, Thomas J. Schall, Lisa Seitz, Peiqi Hu, Craig Gerard, J. Charles Jennette, Norma P. Gerard, Hong Xiao, Yu Wang, Trageen Baumgart, Jay P. Powers, Linda S. Ertl
المصدر: Journal of the American Society of Nephrology. 25:225-231
مصطلحات موضوعية: biology, Inflammation, General Medicine, medicine.disease, C5a receptor, Complement system, Nephrology, Proteinase 3, Myeloperoxidase, Immunology, Alternative complement pathway, medicine, biology.protein, medicine.symptom, Receptor, Vasculitis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::179c872b8b6f873b21c994ff66c7c51aTest
https://doi.org/10.1681/asn.2013020143Test -
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المؤلفون: Timothy J. Sullivan, Jay P. Powers, Juan C. Jaen, Karen Ebsworth, Matthew J. Walters, Penglie Zhang, Thomas J. Schall
المصدر: Immunology Letters. 151(1-2):44-47
مصطلحات موضوعية: Mice, Knockout, Chemokine, CCR9, biology, Ovalbumin, business.industry, Immunology, Administration, Oral, Oral tolerance, Immune tolerance, Mice, Receptors, CCR, Chemokine receptor, Antigen, Immune Tolerance, biology.protein, Animals, Medicine, Immunology and Allergy, Antigens, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671f766968ef968b1710ef6ead42b1fbTest
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5
المؤلفون: Hua Tu, Lisa Julian, Nigel Walker, Maren Gulsrud Willcockson, Yosup Rew, Michael DeGraffenreid, Zhulun Wang, Juan C. Jaen, Daqing Sun, Ron C. Kelly, Athena Sudom, Seb Caille, Jacob Kaizerman, Jay P. Powers, Xuelei Yan, Qiuping Ye, Stefania Ursu, Ben Jiang, Felix Gonzalez-Lopez de Turiso, Randall W. Hungate, Dustin McMinn
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:405-410
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Carboxamide, Crystallography, X-Ray, Biochemistry, Chemical synthesis, 11β hsd1 inhibitors, Structure-Activity Relationship, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Chemistry, Organic Chemistry, Highly selective, Combinatorial chemistry, Rats, Macaca fascicularis, Enzyme, Enzyme inhibitor, Benzamides, Microsomes, Liver, biology.protein, Molecular Medicine, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d541a6a690483f033c76a34f9400098Test
https://doi.org/10.1016/j.bmcl.2010.10.129Test -
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المؤلفون: Tim Park, Jenna L. Jeffrey, Annette Becker, Jay P. Powers, Daniel DiRenzo, Fang-Fang Yin, Nell Narasappa, Jaroslaw Kalisiak, Joanne B. Tan, Ken Lawson, Ulrike Schindler, Kristen Zhang, Matthew J. Walters
المصدر: Cancer Research. 78:710-710
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Effector, Chemistry, Lymphocyte, T cell, CD28, Immune checkpoint, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Immune system, Oncology, TIGIT, medicine, Cancer research, biology.protein, Antibody
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::509e0e2b9536ea9e71b3b2dfedb8f3b2Test
https://doi.org/10.1158/1538-7445.am2018-710Test -
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المؤلفون: Jinsong Liu, Daqing Sun, Tracy Bostick, Randall W. Hungate, Dustin McMinn, Xiao He, Michael DeGraffenreid, Lisa Julian, Juan C. Jaen, Mario Monshouwer, Qiuping Ye, Athena Sudom, Rebekah Choi, Yongmei Di, Yosup Rew, Zhulun Wang, Stefania Ursu, Xuelei Yan, Hua Tu, Seb Caille, Nigel Walker, Jay P. Powers
المصدر: Journal of Medicinal Chemistry. 51:3953-3960
مصطلحات موضوعية: Models, Molecular, Administration, Oral, Dehydrogenase, Crystallography, X-Ray, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Benzamide, chemistry.chemical_classification, Molecular Structure, biology, In vitro, Rats, Macaca fascicularis, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Benzamides, Models, Animal, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6649ad04f55e4735a38d9578744fec1fTest
https://doi.org/10.1021/jm800310gTest -
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المؤلفون: Qiuping Ye, Daqing Sun, Jay P. Powers, Liang Tang, Craig Tomooka, Stefania Ursu, Hua Tu, Yongmei Di, Athena Sudom, Xuelei Yan, Juan C. Jaen, Shichang Miao, Nigel Walker, Ji Ma, Zhulun Wang, Marc Labelle
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:3513-3516
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Nitro compound, Pharmaceutical Science, Dehydrogenase, Crystallography, X-Ray, Biochemistry, Isozyme, Chemical synthesis, Piperazines, Small Molecule Libraries, Mice, Structure-Activity Relationship, Oxidoreductase, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Drug Discovery, Animals, Humans, Sulfhydryl Compounds, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Chemistry, Organic Chemistry, Stereoisomerism, Molecular Weight, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feda87be89ed15aa5be09784f6a201c2Test
https://doi.org/10.1016/j.bmcl.2008.05.025Test -
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المؤلفون: Jinsong Liu, Holger Wesche, Shyun Li, Zhulun Wang, Merrill Ayres, Athena Sudom, Nigel Walker, Jay P. Powers
المصدر: Structure. 14(12):1835-1844
مصطلحات موضوعية: Protein Conformation, Molecular Sequence Data, Glutamic Acid, Biology, Mitogen-activated protein kinase kinase, Crystallography, X-Ray, Protein Structure, Secondary, Receptor tyrosine kinase, Phosphates, MAP2K7, Adenosine Triphosphate, Structural Biology, Humans, Amino Acid Sequence, c-Raf, Enzyme Inhibitors, MOLIMMUNO, Molecular Biology, Serine/threonine-specific protein kinase, Binding Sites, MAP kinase kinase kinase, Protein-Tyrosine Kinases, Interleukin-1 Receptor-Associated Kinases, Biochemistry, SIGNALING, biology.protein, Tyrosine, Cyclin-dependent kinase 9, Tyrosine kinase, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc3d6695128b610622c4cd20aea485fTest
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المؤلفون: Juan C. Jaen, Jay P. Powers, Nigel Walker, Zhulun Wang, Holger Wesche, Jinqian Liu, Shyun Li
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2842-2845
مصطلحات موضوعية: Alkylation, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Interleukin-1 receptor, Biochemistry, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, biology, Kinase, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Amides, Small molecule, Cross-Linking Reagents, Interleukin-1 Receptor-Associated Kinases, Enzyme inhibitor, biology.protein, Cancer research, Molecular Medicine, Benzimidazoles, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aafa1dfbff1d49a203522f7ff6c7cd8cTest
https://doi.org/10.1016/j.bmcl.2006.03.020Test