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المؤلفون: Hsing Jien Kung, Tsai-Yu Tzeng, Chuan-Chuan Chao, Yu-Hui Wong, Ting-Fen Tsai, Po-Wen Shen
المصدر: Biomedicines
Biomedicines, Vol 9, Iss 1635, p 1635 (2021)مصطلحات موضوعية: QH301-705.5, human induced pluripotent stem cells (hiPSCs), Medicine (miscellaneous), Human brain, Review, Biology, induced neurons (iNs), Phenotype, General Biochemistry, Genetics and Molecular Biology, Transcriptome, neuronal senescence, genome editing technology, medicine.anatomical_structure, Genome editing, CRISPR, medicine, brain aging, Epigenetics, Biology (General), Signal transduction, Neuroscience, Immortalised cell line
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7448991840aafe4986737fb88943794Test
http://europepmc.org/articles/PMC8615703Test -
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المؤلفون: Alejandra Suárez-Carrillo, Suleva Povea-Cabello, Marta Talaverón-Rey, Juan M. Suárez-Rivero, José Antonio Sánchez-Alcázar, Irene Villalón-García, Joaquín J. Salas, Manuel Munuera-Cabeza, Mónica Álvarez-Córdoba
المساهمون: Instituto de Salud Carlos III, European Commission, Junta de Andalucía, Asociación de Enfermos de Neurodegeneración con Acumulación Cerebral de Hierro (España), Asociación de Enfermos de Patologías Mitocondriales (España), Federación Española de Enfermedades Raras, Fundación Merck Salud
المصدر: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-16 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)مصطلحات موضوعية: 0301 basic medicine, Neurodegeneration with brain iron accumulation, Coenzyme A, Down-Regulation, Mitochondrion, Pantothenate kinase-associated neurodegeneration, Mitochondrial Proteins, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Pantothenate, Humans, Pharmacology (medical), Acyl carrier protein, Genetics (clinical), biology, 4′-phosphopantetheinylation, Chemistry, Pantothenate kinase, Research, Induced neurons, Neurodegeneration, General Medicine, PANK2, medicine.disease, Mitochondria, Fatty acid synthase, Phosphotransferases (Alcohol Group Acceptor), 030104 developmental biology, Biochemistry, biology.protein, Medicine, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a8c800c9b10fde1200ec50db9c5bcbdTest
http://europepmc.org/articles/PMC8101147Test -
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المؤلفون: Kathryn M. Kim, Mentor Thaqi, Daniel A. Peterson, Robert A. Marr
المصدر: Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Frontiers in Bioengineering and Biotechnologyمصطلحات موضوعية: 0301 basic medicine, Histology, Somatic cell, glia, Mini Review, lcsh:Biotechnology, Cell, Biomedical Engineering, Bioengineering, Biology, 03 medical and health sciences, 0302 clinical medicine, lcsh:TP248.13-248.65, medicine, Epigenetics, Induced pluripotent stem cell, brain repair, Neurogenesis, Bioengineering and Biotechnology, direct reprogramming, induced neurons, neurogenesis, 030104 developmental biology, medicine.anatomical_structure, Olfactory ensheathing glia, Reprogramming, Muller glia, Neuroscience, 030217 neurology & neurosurgery, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16f8d4b1a58f346921add63b55c90406Test
https://www.frontiersin.org/articles/10.3389/fbioe.2021.658498/fullTest -
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المؤلفون: Yuhua Zou, Leilei Wang, Chun Li Zhang, Wenze Niu, Tong Zang
المصدر: Stem Cell Reports, Vol 11, Iss 5, Pp 1156-1170 (2018)
Stem Cell Reportsمصطلحات موضوعية: NURR1, 0301 basic medicine, Aging, striatum, SOX2, Action Potentials, Mice, Transgenic, Stem cell factor, Striatum, Biology, Biochemistry, Article, 03 medical and health sciences, Lateral Ventricles, Genetics, medicine, Animals, Humans, lcsh:QH301-705.5, Cell Proliferation, lcsh:R5-920, dopaminergic neurons, Dopaminergic, HEK 293 cells, in vivo reprogramming, Cell Biology, Cellular Reprogramming, direct reprogramming, Corpus Striatum, Parkinson disease, induced neurons, HEK293 Cells, Phenotype, 030104 developmental biology, medicine.anatomical_structure, nervous system, lcsh:Biology (General), Neuroglia, FOXA2, lcsh:Medicine (General), Neuroscience, Reprogramming, Biomarkers, LMX1A, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5b4cc086b770607af1a169b3412ffe5Test
http://www.sciencedirect.com/science/article/pii/S2213671118303898Test -
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المؤلفون: Alejandra Suárez-Carrillo, Mónica Álvarez-Córdoba, Marta Talaverón-Rey, Irene Villalón-García, José Antonio Sánchez-Alcázar, Manuel Munuera-Cabeza, Suleva Povea-Cabello, Juan M. Suárez-Rivero, Marina Villanueva-Paz
المساهمون: Instituto de Salud Carlos III, European Commission, Ministerio de Educación, Cultura y Deporte (España), Asociación de Enfermos de Patologías Mitocondriales (España)
المصدر: Frontiers in Genetics, Vol 11 (2021)
Frontiers in Geneticsمصطلحات موضوعية: Mitochondrial encephalomyopathy, mitochondrial diseases, Mutation, Mitochondrial DNA, lcsh:QH426-470, mtDNA, Mitochondrial disease, MERRF syndrome, Review, Biology, medicine.disease_cause, medicine.disease, Bioinformatics, direct reprogramming, induced neurons, lcsh:Genetics, Lactic acidosis, disease modeling, Genetics, medicine, Molecular Medicine, Myoclonic epilepsy, Reprogramming, Genetics (clinical)
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22b7f15906c66caefb1d6773b3fec0bTest
https://doi.org/10.3389/fgene.2020.610764Test -
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المؤلفون: Per Qvist, Arne Lund Jørgensen, Ida E. Holm, Mark Denham, Mette Habekost
المصدر: Habekost, M, Qvist, P, Denham, M, Holm, I E & Jørgensen, A L 2021, ' Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration ', Molecular Neurobiology, vol. 58, no. 5, pp. 2075-2087 . https://doi.org/10.1007/s12035-020-02258-wTest
Molecular Neurobiologyمصطلحات موضوعية: Gene isoform, Aging, Swine, Induced Pluripotent Stem Cells, Neuroscience (miscellaneous), tau Proteins, Biology, Splicing, Article, Animals, Genetically Modified, Cellular and Molecular Neuroscience, Amyloid beta-Protein Precursor, medicine, Animals, Humans, Induced pluripotent stem cell, Neurons, Induced neurons, Neurodegeneration, Alternative splicing, Brain, Neurodegenerative Diseases, Human brain, medicine.disease, Embryonic stem cell, Porcine models, Cell biology, Alternative Splicing, medicine.anatomical_structure, Neurology, RNA splicing, Nerve Degeneration, Tau, APP, Reprogramming, Alzheimer’s disease
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ff73e30ad5ebeae5ac6307f6f817ae7Test
https://pure.au.dk/portal/da/publications/directly-reprogrammedTest-neurons -express-mapt-and-app-splice-variants-pertinent-to-ageing-and-neurodegeneration(bd439746-0fed-4128-a295-3a23e3d461ab).html -
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المؤلفون: Tiago Cardoso, Martin Lévesque
المصدر: Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Frontiers in Cell and Developmental Biologyمصطلحات موضوعية: 0301 basic medicine, Parkinson's disease, cell replacement therapy, Cell, Review, Biology, single cell sequencing, Midbrain, 03 medical and health sciences, Cell and Developmental Biology, 0302 clinical medicine, Dopamine, medicine, Induced pluripotent stem cell, lcsh:QH301-705.5, dopaminergic neurons, cell reprogramming, Dopaminergic, Cell Biology, medicine.disease, 3. Good health, induced neurons, Electrophysiology, 030104 developmental biology, medicine.anatomical_structure, Single cell sequencing, nervous system, lcsh:Biology (General), 030220 oncology & carcinogenesis, Parkinson’s disease, pluripotent stem cells, Neuroscience, Developmental Biology, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb70311d40328735e8104eab14d5c871Test
https://www.frontiersin.org/article/10.3389/fcell.2020.00443/fullTest -
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المؤلفون: Arne Lund Jørgensen, Mette Habekost, Per Qvist, Mark Denham
المصدر: Stem Cell Research, Vol 48, Iss, Pp 101984-(2020)
Habekost, M, Jørgensen, A L, Qvist, P & Denham, M 2020, ' MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons ', Stem Cell Research, vol. 48, 101984, pp. 101984 . https://doi.org/10.1016/j.scr.2020.101984Testمصطلحات موضوعية: 0301 basic medicine, Direct reprogramming, Somatic cell, Swine, Cell, ADULT HUMAN FIBROBLASTS, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Porcine induced neurons, Neuronal conversion, BRAIN, Transcription factor, lcsh:QH301-705.5, Neurons, biology, REST, MicroRNA, IN-VITRO, Cell Biology, General Medicine, Fibroblasts, Cellular Reprogramming, Cell biology, ASCL1, MicroRNAs, 030104 developmental biology, medicine.anatomical_structure, nervous system, Disease modelling, lcsh:Biology (General), FUNCTIONAL-NEURONS, NEUROD1, Regenerative medicine, Synaptophysin, biology.protein, Neuron, PLURIPOTENT STEM-CELLS, 030217 neurology & neurosurgery, Developmental Biology, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c0265dc9ad051109eb3e90cea830fbTest
https://pubmed.ncbi.nlm.nih.gov/32971463Test -
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المؤلفون: Ting Gao, Yi Fang, Jing Hu, Chong-Yao Jin, Shao-Bing Dai, Ran Zheng, Baorong Zhang, Jiali Pu
المصدر: Brain and Behavior, Vol 9, Iss 12, Pp n/a-n/a (2019)
Brain and Behaviorمصطلحات موضوعية: rho GTP-Binding Proteins, Neurite, GTPase, Cell Growth Processes, Biology, medicine.disease_cause, 050105 experimental psychology, lcsh:RC321-571, 03 medical and health sciences, Behavioral Neuroscience, idiopathic congenital nystagmus, 0302 clinical medicine, Rho GTPases, medicine, Biological neural network, Humans, 0501 psychology and cognitive sciences, Cellular Reprogramming Techniques, Cytoskeleton, CRISPR/Cas9, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cells, Cultured, Original Research, Neurons, Mutation, FRMD7, 05 social sciences, Membrane Proteins, Genetic Diseases, X-Linked, Phenotype, induced neurons, Cytoskeletal Proteins, medicine.anatomical_structure, nervous system, neuronal outgrowth, Neuron, Neuroscience, Reprogramming, Nystagmus, Congenital, 030217 neurology & neurosurgery, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a508597f979b7b1a7db75492f1a34e7dTest
https://doaj.org/article/6ab8d34c4da340eb9b27c2496ab32540Test -
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المؤلفون: Shauna H. Yuan, Johannes C. M. Schlachetzki, Fred H. Gage, Dylan A. Reid, Apuã C. M. Paquola, Raffaella Lucciola, Shani Stern, Attila Szücs, Larissa Traxler, Steve Horvath, Lena Böhnke, Douglas Galasko, Simon T. Schafer, Frank Edenhofer, Christopher K. Glass, Dina Zangwill, Lukas Karbacher, Jerome Mertens, Diana P. Fernandes, Lucia Zhou-Yang, Lawrence S.B. Goldstein, Manching Ku, Hyungjun Lee, Joseph R. Herdy, Ravi K. Agarwal
المصدر: Cell Stem Cell
مصطلحات موضوعية: Aging, Ontogeny, Induced Pluripotent Stem Cells, rejuvenation, neuronal cell cycle re-entry, Age dependent, Biology, induced neurons (iNs), Article, Malignant transformation, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, Alzheimer Disease, Genetics, Humans, Epigenetics, Aged, 030304 developmental biology, Neurons, 0303 health sciences, de-differentiation, Cell Biology, Alzheimer's disease, Fibroblasts, Cell cycle, nervous system, Molecular Medicine, Signal transduction, Neuroscience, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee680604bac20b52230ab834cd93afcTest
https://doi.org/10.1016/j.stem.2021.04.004Test
