المؤلفون: Stuart A. Rushworth, Arasu Ganesan, Simon J. Crabb, Kristian M. Bowles, Maria Teresa Borrello, Graham Packham, Hanae Benelkebir, Manar S. Shafat, Sarah G. Bailey, Patrick J. Duriez, Chak Hin Tam, Adam Lee, Leon Douglas

المصدر: ChemMedChem. 16:1316-1324

مصطلحات موضوعية: animal structures, Cell Survival, medicine.drug_class, Antineoplastic Agents, Carboxamide, Pharmacology, 01 natural sciences, Biochemistry, Cell Line, Tumor, Drug Discovery, medicine, Humans, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Cell Proliferation, Histone Demethylases, biology, 010405 organic chemistry, Chemistry, Cell growth, Organic Chemistry, Tranylcypromine, Myeloid leukemia, KDM1A, Prodrug, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Cell culture, biology.protein, Molecular Medicine, Demethylase, Drug Screening Assays, Antitumor, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666ccb179d2deaae73378780b6870138Test
https://doi.org/10.1002/cmdc.202000754Test

المؤلفون: Dean Bryant, George E. Wright, James S. Blachly, Jonathan C. Strefford, Graham Packham, Carl G. Figdor, Francesco Forconi, Isla Henderson, Thomas A. Bowden, Giorgia Chiodin, Teunis B. H. Geijtenbeek, Beatriz Valle-Argos, Philip J. Rock, Enrica Antonia Martino, Patrick J. Duriez, Freda K. Stevenson, Yasunori Watanabe, Katy J. McCann, Louis M. Staudt, Max Crispin, Joel D. Allen, Richard Burack

المساهمون: AII - Cancer immunology, Experimental Immunology, Infectious diseases, CCA - Cancer biology and immunology

المصدر: Blood, 138(17), 1570-1582. American Society of Hematology
Blood, 138, 17, pp. 1570-1582
Blood, 138, 1570-1582
Blood

مصطلحات موضوعية: Glycosylation, Surface Immunoglobulin, Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2], Immunology, Follicular lymphoma, Receptors, Antigen, B-Cell, Receptors, Cell Surface, Biology, Biochemistry, chemistry.chemical_compound, Polysaccharides, hemic and lymphatic diseases, medicine, Tumor Cells, Cultured, Humans, Lectins, C-Type, Protein Interaction Domains and Motifs, PI3K/AKT/mTOR pathway, Lymphoid Neoplasia, Binding Sites, Germinal center, Cell Biology, Hematology, medicine.disease, Complementarity Determining Regions, Tumor antigen, Lymphoma, chemistry, biology.protein, Cancer research, Lymphoma, Large B-Cell, Diffuse, Antibody, Sugars, Cell Adhesion Molecules

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29c1bc1823f404e2a7f19678b1ca290Test
https://hdl.handle.net/2066/244632Test

المؤلفون: Rachel Fell, Kerry L. Cox, Mark S. Cragg, Thomas Cummin, Peter Johnson, Anna H. Turaj, Lisa Dunning, Tom D Murray, Matthew J. Carter, Vikki English, Graham Packham, Yan Ma, Ben Powell

المصدر: Blood Adv

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Pyridines, Apoptosis, Nerve Tissue Proteins, Receptors, Cell Surface, Biology, Proto-Oncogene Proteins c-myc, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Downregulation and upregulation, In vivo, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Animals, Pyrroles, Oxazoles, Psychological repression, Sulfonamides, Lymphoid Neoplasia, Venetoclax, Hematology, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Lymphoma, Bromodomain, 030104 developmental biology, Proto-Oncogene Proteins c-bcl-2, chemistry, 030220 oncology & carcinogenesis, Cancer research

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c7b9768ccf26053b1ab4dec84131daTest
https://doi.org/10.1182/bloodadvances.2020002231Test

المؤلفون: Graham Packham, Alison Yeomans, Joe Taylor

المصدر: Exploration of targeted anti-tumor therapy
Exploration of Targeted Anti-tumor Therapy, Vol 1, Iss 1, Pp 3-25 (2020)

مصطلحات موضوعية: 0301 basic medicine, lcsh:Internal medicine, mRNA translation, Chronic lymphocytic leukemia, Follicular lymphoma, lymphoma, Biology, Article, 03 medical and health sciences, 0302 clinical medicine, Eukaryotic initiation factor, medicine, Protein biosynthesis, Initiation factor, lcsh:RC31-1245, Tumor microenvironment, leukemia, drug, Translation (biology), medicine.disease, initiation, inhibitor, Leukemia, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b2f13be77853aa71eef9a32c9f89e9Test
http://europepmc.org/articles/PMC7116065Test

المؤلفون: Karina Close, Jun Wang, Tahrima Rahim, Sameena Iqbal, Findlay Bewicke-Copley, Andrew Clear, Martin Philpott, Annalisa D'Avola, Lola Konali, James A. Heward, Emil Kumar, Udo Oppermann, Richard Neve, Maria Calaminici, Pedro R. Cutillas, Jessica Okosun, Peter Johnson, Koorosh Korfi, John G. Gribben, Darko Barisic, Ahad F. Al Seraihi, James E. Dunford, Alison Yeomans, Ari Melnick, Shamzah Araf, Jude Fitzgibbon, Graham Packham

المصدر: Blood

مصطلحات موضوعية: 0301 basic medicine, Immunology, Mutant, medicine.disease_cause, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Loss of Function Mutation, Cell Line, Tumor, Gene expression, medicine, Animals, Humans, Enzyme Inhibitors, Mutation, biology, Chemistry, Germinal center, Cell Biology, Hematology, Methylation, medicine.disease, Xenograft Model Antitumor Assays, Neoplasm Proteins, Lymphoma, DNA-Binding Proteins, 030104 developmental biology, Histone, biology.protein, Cancer research, H3K4me3, Lymphoma, Large B-Cell, Diffuse, Erratum, Retinoblastoma-Binding Protein 2, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69f75b8e11d8e8cb74d2e87d8a74550Test
https://ora.ox.ac.uk/objects/uuid:7efc616c-0a6f-4725-8739-6ff679a99852Test

المؤلفون: Francesco Forconi, Giorgia Chiodin, Jonathan C. Strefford, Freda K. Stevenson, Graham Packham, Richard Burack, Beatriz Valle-Argos, Joe Taylor, Dean Bryant, Elizabeth Lemm, Patrick J. Duriez, Philip J. Rock

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: 0301 basic medicine, Receptors, CXCR4, Glycosylation, Surface Immunoglobulin, Science, Cell, B-cell receptor, Follicular lymphoma, Receptors, Antigen, B-Cell, Somatic hypermutation, Receptors, Cell Surface, Article, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, medicine, Humans, Lectins, C-Type, Calcium Signaling, Receptor, Lymphoma, Follicular, Cancer, Multidisciplinary, biology, Chemistry, Calcium signalling, medicine.disease, Cell biology, Gene Expression Regulation, Neoplastic, DC-SIGN, 030104 developmental biology, medicine.anatomical_structure, Immunoglobulin M, Cell culture, 030220 oncology & carcinogenesis, biology.protein, Medicine, Tumour immunology, Calcium, Gene expression, Cell Adhesion Molecules, Cell signalling, Protein Binding, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac055fc18ce80b4078979b7fe6090b9aTest
https://doi.org/10.1038/s41598-021-91112-7Test

المؤلفون: Teresa Borrello, Chak Hin Tam, Manar Shafat, Stuart Rushworth, Kristian Bowles, Sarah Bailey, Simon Crabb, Graham Packham, Patrick J. Duriez, Pr. Ganesan, Hanae Benelkebir, Leonard Douglas

مصطلحات موضوعية: CD86, animal structures, biology, Chemistry, medicine.drug_class, Tranylcypromine, Myeloid leukemia, Carboxamide, KDM1A, Histone, Cell culture, biology.protein, medicine, Cancer research, Demethylase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56b848e80df0e632318bc3426bbd46fTest
https://doi.org/10.26434/chemrxiv.11860824.v2Test

المؤلفون: Lola Koniali, Karina Close, Richard Neve, Maria Calaminici, Martin Philpott, Tahrima Rahim, Ahad F. Al Seraihi, Alison Yeomans, John G. Gribben, Findlay Bewicke-Copley, Andrew Clear, Jude Fitzgibbon, Graham Packham, James A. Heward, Jessica Okosun, Koorosh Korfi, Emil Kumar, Peter Johnson, Sameena Iqbal, Ari Melnick, Shamzah Araf, Udo Oppermann, James E. Dunford, Jun Wang, Annalisa D'Avola, Darko Barisic

مصطلحات موضوعية: biology, Cell culture, Histone methyltransferase, Mutant, Gene expression, biology.protein, Cancer research, Demethylase, H3K4me3, Endogeny, Gene

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::767ce07069098562f94d88c6d06275e7Test
https://doi.org/10.1101/2020.06.30.177477Test

المؤلفون: Johanna Richter, Jana Karolova, Yohannes Gebreselassie, Georg Lenz, Chris T. Williamson, Mark S. Cragg, Michael Svaton, Beatriz Valle-Argos, Lindsay D. Smith, Elizabeth Lemm, Nicola J. Weston-Bell, Graham Packham, Laura I. Karydis, Andrew J. Steele, Curtis Harwig, Karel Helman, Freda K. Stevenson, Pavel Klener, Matthew J. Carter, Jennifer Cross, Francesco Forconi, Lloyd F Mackenzie, Jeremy D Pettigrew

المصدر: Clin Cancer Res

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Chronic lymphocytic leukemia, Syk, Enzyme Activators, Antineoplastic Agents, Apoptosis, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, Phosphatidylinositol 3-Kinases, 0302 clinical medicine, Mice, Inbred NOD, hemic and lymphatic diseases, Cell Line, Tumor, medicine, Bruton's tyrosine kinase, Animals, Humans, PI3K/AKT/mTOR pathway, biology, Chemistry, Kinase, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Xenograft Model Antitumor Assays, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Ibrutinib, Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases, biology.protein, Cancer research, Phosphorylation, Female, Lymphoma, Large B-Cell, Diffuse, Signal transduction, Sesquiterpenes, Signal Transduction

وصف الملف: text

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14b2de6e33034fe5f7f6794dee808d8Test
https://europepmc.org/articles/PMC7124891Test/

المؤلفون: Eric Eldering, Beatriz Valle-Argos, Zhenghao Chen, Graham Packham, Gaspard Cretenet, Francesco Forconi, Arnon P. Kater

المصدر: Blood. 136:36-37

مصطلحات موضوعية: CD40, biology, Chronic lymphocytic leukemia, Immunology, B-cell receptor, breakpoint cluster region, Cell Biology, Hematology, medicine.disease, Biochemistry, chemistry.chemical_compound, chemistry, Ibrutinib, biology.protein, Cancer research, medicine, Bruton's tyrosine kinase, CD5, Tyrosine kinase

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::071dbdcfdc96eba0a03a040a4ca7fcabTest
https://doi.org/10.1182/blood-2020-142839Test