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المؤلفون: Yongbo Hu, Karen Collins, Edward J. Salaski, Nancy Torres, Eileen Frommer, Dennis Powell, Wang Xiaolun, Jeremy I. Levin, Donald Wojciechowicz, Dan Maarten Berger
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6571-6574
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins B-raf, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Substrate Specificity, Structure-Activity Relationship, Pyrimidine analogue, Drug Discovery, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Kinase, Organic Chemistry, In vitro, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981acddc510eaf8186f924c43131f046Test
https://doi.org/10.1016/j.bmcl.2009.10.030Test -
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المؤلفون: Nancy Torres, Eileen Frommer, Bloom Jonathan David, Karen Collins, Dunnick Alejandro Lee, George Diamantidis, Yongbo Hu, Minu Dutia, Christoph W. Zapf, Zhang Chunchun, Darrin William Hopper, Dan Maarten Berger, Donald Wojciechowicz, Dennis Powell, Martin Di Grandi, Jeremy I. Levin
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6957-6961
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyridines, Isostere, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Enzyme Inhibitors, Cytotoxicity, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Indazole, biology, Bicyclic molecule, Cell growth, Organic Chemistry, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6346230a46b93ee107f73ab7d8869701Test
https://doi.org/10.1016/j.bmcl.2009.10.058Test -
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المؤلفون: Rob Van Soest, Akbar Tahir, Robert Mallon, Irwin Hollander, David E. Williams, Raymond J. Andersen, Larry Feldberg, Eileen Frommer
المصدر: Journal of Natural Products. 72:1106-1109
مصطلحات موضوعية: Sesterterpenes, Stereochemistry, medicine.medical_treatment, Pharmaceutical Science, Marine Biology, Tumor cells, Biology, Animal origin, Analytical Chemistry, Carteriospongia foliascens, Endopeptidases, Drug Discovery, medicine, Animals, Humans, Protease Inhibitors, Pharmacology, Protease, Molecular Structure, Extramural, Organic Chemistry, biology.organism_classification, Porifera, Sponge, Complementary and alternative medicine, Biochemistry, Indonesia, Molecular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd31a3b2af8ada25421ea61a271139b4Test
https://doi.org/10.1021/np900042rTest -
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المؤلفون: Steven C. Kim, Frederick Lee, Eileen Frommer, Mengxiao Shi, Yongbo Hu, Donald Wojciechowicz, Robert Mallon, Greg Ciszewski, Dan Maarten Berger, Karen Collins, Ariamala Gopalsamy, Larry Feldberg
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:6890-6892
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrimidine, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Carboxamide, Biochemistry, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Hit to lead, Pyrimidines, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Pyrazoles, Molecular Medicine, Signal transduction, Lead compound
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6af29a6344c217dfecdc0daf235230Test
https://doi.org/10.1016/j.bmcl.2009.10.074Test -
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المؤلفون: Karen Collins, Steven C. Kim, Donald Wojciechowicz, Larry Feldberg, Frederick Lee, Eileen Frommer, Yongbo Hu, Robert Mallon, Ariamala Gopalsamy, Greg Ciszewski
المصدر: Bioorganicmedicinal chemistry letters. 19(10)
مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Pyrimidine, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Humans, Computer Simulation, Molecular Biology, Protein Kinase Inhibitors, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, Small molecule, In vitro, Enzyme, Pyrimidines, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8e36f6b9ef3c487a3b1c921c05d988Test
https://pubmed.ncbi.nlm.nih.gov/19362830Test -
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المؤلفون: Raymond J. Andersen, David E. Williams, Irwin Hollander, Akbar Tahir, Donald Wojciechowicz, Rob W. M. Van Soest, Karen Collins, Eileen Frommer, Robert Mallon, Kyle S. Craig
المساهمون: Systematische en Geografische Dierkunde (inactive) (IBED, FNWI)
المصدر: Tetrahedron Letters, 43, 4801-4804. Elsevier
مصطلحات موضوعية: Protease, biology, Chemistry, Stereochemistry, medicine.medical_treatment, Organic Chemistry, biology.organism_classification, Biochemistry, Terpenoid, Hippospongia, Sponge, Drug Discovery, medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e95a66fa3ad03ea43b70cac32f6a62bTest
https://dare.uva.nl/personal/pure/en/publications/novel-sesterterpenoid-and-norsesterterpenoid-rceprotease-inhibitors-isolated-from-the-marine-sponge-hippospongia-spTest(43f45c56-7e33-4056-859f-ba243dd10e1d).html -
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المؤلفون: Wang Xiaolun, Levin I. Jeremy, Nancy Torres, Donald Wojciechowicz, Edward J. Salaski, Yongbo Hu, Eileen Frommer, Dan Maarten Berger, Dennis Powell, Karen Collins
المصدر: Molecular Cancer Therapeutics. 8:A85-A85
مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, Kinase, Cell, Wild type, Biology, Serine, Enzyme, medicine.anatomical_structure, Oncology, Biochemistry, chemistry, Cell culture, medicine, Signal transduction, Protein kinase A
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::524814e839cb0deb10ba60886cd95053Test
https://doi.org/10.1158/1535-7163.targ-09-a85Test