-
1
المساهمون: DE FALCO, S., Russo, G., Angiolillo, A., Pietropaolo, Concetta
المصدر: Gene (Amst.) 126 (1993): 227–235. doi:10.1016/0378-1119(93)90371-9
info:cnr-pdr/source/autori:DE FALCO S, RUSSO G, ANGIOLILLO A, PIETROPAOLO C/titolo:HUMAN L7A RIBOSOMAL-PROTEIN-SEQUENCE, STRUCTURAL ORGANIZATION, AND EXPRESSION OF A FUNCTIONAL GENE/doi:10.1016%2F0378-1119(93)90371-9/rivista:Gene (Amst.)/anno:1993/pagina_da:227/pagina_a:235/intervallo_pagine:227–235/volume:126مصطلحات موضوعية: Ribosomal Proteins, Molecular Sequence Data, Restriction Mapping, Biology, Regulatory Sequences, Nucleic Acid, Conserved sequence, Conserved non-coding sequence, Exon, Mice, Sequence Homology, Nucleic Acid, Gene cluster, Genetics, Coding region, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Gene, Base Sequence, Sequence Homology, Amino Acid, General Medicine, DNA, Biological Evolution, Nested gene, Gene Expression Regulation, Regulatory sequence, Dinucleoside Phosphates
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51815061669f8db036829568f63f2c36Test
https://pubmed.ncbi.nlm.nih.gov/8482538Test -
2
المؤلفون: Giuseppe D'Alessio, Sandro De Falco, Maria Vittoria Cubellis, Elio Pizzo, Antimo Di Maro, Natalina Quarto, Salvatore Ponticelli, Pasquale Buonanno
المساهمون: Pizzo, Eliodoro, Buonanno, P., Di Maro, A., Ponticelli, S., De Falco, S., Quarto, Natalina, Cubellis, MARIA VITTORIA, D'Alessio, Giuseppe, Pizzo, E, Buonanno, P, DI MARO, Antimo, Ponticelli, S, DE FALCO, S, Quarto, N, CUBELLIS M., V, D'Alessio, G.
المصدر: The Journal of biological chemistry
281 (2006): 27454–27460. doi:10.1074/jbc.M605505200
info:cnr-pdr/source/autori:Pizzo E, Buonanno P, Di Maro A, Ponticelli S, De Falco S, Quarto N, Cubellis MV, D'Alessio G./titolo:Ribonucleases and angiogenins from fish./doi:10.1074%2Fjbc.M605505200/rivista:The Journal of biological chemistry (Print)/anno:2006/pagina_da:27454/pagina_a:27460/intervallo_pagine:27454–27460/volume:281مصطلحات موضوعية: Models, Molecular, Angiogenin, RNase P, Molecular Sequence Data, Danio, Neovascularization, Physiologic, Bioinformatics, Biochemistry, law.invention, Ribonucleases, law, biology.animal, Animals, Humans, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, Gene, Zebrafish, Phylogeny, Neovascularization, Pathologic, Sequence Homology, Amino Acid, biology, Vertebrate, Ribonuclease, Pancreatic, Cell Biology, biology.organism_classification, Kinetics, Phylogenesis, Recombinant DNA
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef4bb6a664a3a264aad13b3276156daeTest
https://doi.org/10.1074/jbc.m605505200Test -
3
المؤلفون: Elena Marrocco, Brunella Franco, Valeria Tarallo, Sandro De Falco, Elvira De Leonibus, Filomena Grazia Alvino, Anna Carboncino, Federica Esposito, Alessia Indrieri, Maria De Risi
المساهمون: Marrocco, E., Indrieri, A., Esposito, F., Tarallo, V., Carboncino, A., Alvino, F. G., De Falco, S., Franco, B., De Risi, M., De Leonibus, E.
المصدر: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific reports (Nature Publishing Group) 10 (2020): 9619. doi:10.1038/s41598-020-66497-6
info:cnr-pdr/source/autori:Marrocco E.; Indrieri A.; Esposito F.; Tarallo V.; Carboncino A.; Alvino F.G.; De Falco S.; Franco B.; De Risi M.; De Leonibus E./titolo:alpha-synuclein overexpression in the retina leads to vision impairment and degeneration of dopaminergic amacrine cells/doi:10.1038%2Fs41598-020-66497-6/rivista:Scientific reports (Nature Publishing Group)/anno:2020/pagina_da:9619/pagina_a:/intervallo_pagine:9619/volume:10مصطلحات موضوعية: Male, Visual acuity, genetic structures, Parkinson's disease, Cell death in the nervous system, Vision Disorders, Visual Acuity, lcsh:Medicine, Fluorescent Antibody Technique, Biology, Article, Retina, Levodopa, Mice, chemistry.chemical_compound, Dopamine, medicine, Animals, lcsh:Science, PARKINSONS-DISEASE, VISUAL-ACUITY, WATER MAZE, TRANSDUCTION, SENSITIVITY, TYROSINE, Synucleinopathies, Multidisciplinary, medicine.diagnostic_test, Animal, Dopaminergic Neurons, lcsh:R, Vision Disorder, Retinal Degeneration, Dopaminergic, Retinal, Amacrine Cell, eye diseases, nervous system diseases, Mice, Inbred C57BL, Amacrine Cells, medicine.anatomical_structure, chemistry, alpha-Synuclein, lcsh:Q, Female, sense organs, medicine.symptom, Dopaminergic Neuron, Erg, Neuroscience, Electroretinography, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071c13586a23c2be8dc8990197665f39Test
https://doi.org/10.1038/s41598-020-66497-6Test -
4
المؤلفون: Annamaria Sandomenico, Silvia Scaramuzza, Fabio Selis, Emanuela Iaccarino, Luisa Calvanese, Andrea Esperti, Emanuela Truppo, Paolo Dell'Omo, Maria Cantile, Sandro De Falco, Lucia Falcigno, Menotti Ruvo, Andrea Caporale, Riccardo Sanna, Giancarlo Tonon, Annalia Focà
المساهمون: Selis, F., Sandomenico, A., Cantile, M., Sanna, R., Calvanese, L., Falcigno, L., Dell'Omo, P., Esperti, A., De Falco, S., Foca, A., Caporale, A., Iaccarino, E., Truppo, E., Scaramuzza, S., Tonon, G., Ruvo, M.
المصدر: International journal of biological macromolecules 164 (2020): 4516–4531. doi:10.1016/j.ijbiomac.2020.09.050
info:cnr-pdr/source/autori:Selis F.; Sandomenico A.; Cantile M.; Sanna R.; Calvanese L.; Falcigno L.; Dell'Omo P.; Esperti A.; De Falco S.; Foca A.; Caporale A.; Iaccarino E.; Truppo E.; Scaramuzza S.; Tonon G.; Ruvo M./titolo:Generation and testing of engineered multimeric Fabs of trastuzumab/doi:10.1016%2Fj.ijbiomac.2020.09.050/rivista:International journal of biological macromolecules/anno:2020/pagina_da:4516/pagina_a:4531/intervallo_pagine:4516–4531/volume:164مصطلحات موضوعية: Models, Molecular, Immunoconjugates, Protein Conformation, Receptor, ErbB-2, Peptide, 02 engineering and technology, Protein Engineering, Biochemistry, law.invention, Structural Biology, law, Cytotoxic T cell, Internalization, media_common, chemistry.chemical_classification, Transglutamination, 0303 health sciences, biology, Chemistry, General Medicine, Antibody fragment, Bioconjugation, Trastuzumab, Recombinant Fab, 021001 nanoscience & nanotechnology, Recombinant Proteins, Recombinant DNA, Cystine, Female, Antibody, 0210 nano-technology, DNA, Complementary, media_common.quotation_subject, Breast Neoplasms, 03 medical and health sciences, Immunoglobulin Fab Fragments, Cell Line, Tumor, Escherichia coli, Humans, Amino Acid Sequence, Molecular Biology, 030304 developmental biology, Fluorescent Dyes, Transglutaminases, Carcinoma, Periplasmic space, Surface Plasmon Resonance, Peptide Fragments, Drug Design, biology.protein, Drug Screening Assays, Antitumor, Protein Multimerization, Conjugate
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c83f8eb5924b3f47cced55512ce8abTest
http://hdl.handle.net/11588/825466Test -
5
المؤلفون: Ivana Apicella, Sasha Bogdanovich, Bradley D. Gelfand, Arturo Brunetti, J. Sjef Verbeek, Charles B. Wright, Shengjian Li, Younghee Kim, Laura Tudisco, Tetsuhiro Yasuma, Jeanette H. W. Leusen, Yoshio Hirano, Ana Bastos-Carvalho, Jayakrishna Ambati, Takeshi Mizutani, Sandro De Falco, Valeria Cicatiello, Ingrid E. Lundberg, Benjamin J. Fowler, Balamurali K. Ambati, Adelaide Greco, Valeria Tarallo, Nagaraj Kerur, Sevim Barbasso Helmers, Ondrej Viklicky, Reo Yasuma
المساهمون: Yasuma, R, Cicatiello, V, Mizutani, T, Tudisco, L, Kim, Y, Tarallo, V, Bogdanovich, S, Hirano, Y, Kerur, N, Li, S, Yasuma, T, Fowler, Bj, Wright, Cb, Apicella, I, Greco, Adelaide, Brunetti, Arturo, Ambati, Bk, Helmers, Sb, Lundberg, Ie, Viklicky, O, Leusen, Jh, Verbeek, J, Gelfand, Bd, Bastos Carvalho, A, De Falco, S, Ambati, J.
المصدر: Signal Transduction and Targeted Therapy ( 1 (2016). doi:10.1038/sigtrans.2015.2
info:cnr-pdr/source/autori:Yasuma R, Cicatiello V, Mizutani T, Tudisco L, Kim Y, Tarallo V, Bogdanovich S, Hirano Y, Kerur N, Li S, Yasuma T, Fowler BJ, Wright CB, Apicella I, Greco A, Brunetti A, Ambati BK, Helmers SB, Lundberg IE, Viklicky O, Leusen JH, Verbeek JS, Gelfand BD, Bastos-Carvalho A, De Falco S, Ambati J./titolo:Intravenous immune globulin suppresses angiogenesis in mice and humans./doi:10.1038%2Fsigtrans.2015.2/rivista:Signal Transduction and Targeted Therapy (/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume:1
Signal Transduction and Targeted Therapy
Signal transduction and targeted therapy, 1. Springer Natureمصطلحات موضوعية: 0301 basic medicine, Genetically modified mouse, Cancer Research, Angiogenesis, Article, 03 medical and health sciences, angiogenesis, hemic and lymphatic diseases, Genetics, medicine, Journal Article, Receptor, biology, immuneglobuline, angioinhibition, mice, business.industry, medicine.disease, immune globulin, Fragment crystallizable region, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Polyclonal antibodies, Corneal neovascularization, Immunology, biology.protein, Antibody, business, Blood vessel
وصف الملف: image/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4093348e195c601186890e5a60286468Test
https://dspace.library.uu.nl/handle/1874/341293Test -
6
المؤلفون: Clare L. Parish, Sandro De Falco, Enza Lonardo, Salvatore Ponticelli, Ernest Arenas, Gabriella Minchiotti, Menotti Ruvo, Diogo Ribeiro, Daniela Marasco
المساهمون: Lonardo, E., Parish, C. L., Ponticelli, S., Marasco, Daniela, Ribeiro, D., Ruvo, M., De Falco, S., Arenas, E., Minchiotti, G.
المصدر: Stem cells (Dayt. Ohio) 28 (2010): 1326–1337. doi:10.1002/stem.458
info:cnr-pdr/source/autori:Lonardo E.; Parish C.L.; Ponticelli S.; Marasco D.; Ribeiro D.; Ruvo M.; De Falco S.; Arenas E.; Minchiotti G./titolo:A Small Synthetic Cripto Blocking Peptide Improves Neural Induction, Dopaminergic Differentiation and Functional Integration of Mouse Embryonic Stem Cells in a Rat Model of Parkinson's Disease/doi:10.1002%2Fstem.458/rivista:Stem cells (Dayt. Ohio)/anno:2010/pagina_da:1326/pagina_a:1337/intervallo_pagine:1326–1337/volume:28
info:cnr-pdr/source/autori:Lonardo E, Parish CL, Ponticelli S, Marasco D, Ribeiro D, Ruvo M, De Falco S, Arenas E, Minchiotti G/titolo:A small synthetic cripto blocking Peptide improves neuralinduction, dopaminergic differentiation, and functional integration of mouseembryonic stem cells in a rat model of Parkinson's disease/doi:10.1002%2Fstem.458/rivista:Stem cells (Dayt. Ohio)/anno:2010/pagina_da:1326/pagina_a:1337/intervallo_pagine:1326–1337/volume:28مصطلحات موضوعية: Library, Embryonic stem cells, medicine.medical_specialty, Parkinson's disease, Cellular therapy, Biology, Cripto, Cell therapy, Mice, Internal medicine, medicine, Animals, Neurons, Membrane Glycoproteins, Epidermal Growth Factor, Neuroectoderm, Reverse Transcriptase Polymerase Chain Reaction, Cell Differentiation, Parkinson Disease, Cell Biology, Activin receptor, Embryonic stem cell, Neoplasm Proteins, Rats, Cell biology, stem cell, Disease Models, Animal, Endocrinology, parkinson, Neuron differentiation, Molecular Medicine, Neural differentiation, Cell transplantation, NODAL, Activin Receptors, Type I, Oligopeptides, Neural development, hormones, hormone substitutes, and hormone antagonists, Protein Binding, Stem Cell Transplantation, Developmental Biology
وصف الملف: ELETTRONICO
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e002d1a39e39b84059d14ed8dfb0a3edTest
https://doi.org/10.1002/stem.458Test -
7
المؤلفون: Valeria Tarallo, Roberto Bianco, Davide Melisi, Anderson J. Ryan, Vincenzo Damiano, Roberta De Rosa, Gennaro Daniele, Giampaolo Tortora, Sandro De Falco, Teresa Gelardi, Sonia Garofalo, Adriana Albini, Roberto Benelli, Fortunato Ciardiello
المساهمون: Bianco, Roberto, Rosa, R, Damiano, V, Daniele, G, Gelardi, T, Garofalo, S, Tarallo, V, De Falco, S, Melisi, D, Benelli, R, Albini, A, Ryan, A, Ciardiello, F, Tortora, G.
المصدر: Clinical cancer research
14 (2008): 5069–5080. doi:10.1158/1078-0432.CCR-07-4905
info:cnr-pdr/source/autori:Bianco R.; Rosa R.; Damiano V.; Daniele G.; Gelardi T.; Garofalo S.; Tarallo V.; De Falco S.; Melisi D.; Benelli R.;Albini A.; Ryan A.; Ciardiello F.; Tortora G./titolo:Vascular endothelial growth factor receptor-1 contributes to resistance to anti-epidermal growth factor receptor drugs in human cancer cells/doi:10.1158%2F1078-0432.CCR-07-4905/rivista:Clinical cancer research (Print)/anno:2008/pagina_da:5069/pagina_a:5080/intervallo_pagine:5069–5080/volume:14مصطلحات موضوعية: Cancer Research, EGFR, Blotting, Western, Drug Resistance, Antineoplastic Agents, Biology, Transfection, Vandetanib, Cell Line, resistance, Piperidines, Cell Movement, Cell Line, Tumor, Neoplasms, Cell Adhesion, medicine, Humans, Immunoprecipitation, Gene silencing, Cell Proliferation, Drug Resistance, Neoplasm, Quinazolines, RNA Interference, Receptor, Epidermal Growth Factor, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Vascular Endothelial Growth Factor Receptor-1, Protein kinase B, EGFR inhibitors, Tumor, Epidermal Growth Factor, Blotting, Cell growth, Kinase, VEGF, TYROSINE KINASE INHIBITOR, ACQUIRED-RESISTANCE, TUMOR ANGIOGENESIS VEGF, ANTITUMOR-ACTIVITY, ErbB Receptors, Oncology, Cancer research, Neoplasm, Signal transduction, Western, Receptor, medicine.drug
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2159185920e0d462df022869adc266b1Test
https://doi.org/10.1158/1078-0432.ccr-07-4905Test -
8
المؤلفون: Roberta Cotugno, Fabrizio Dal Piaz, Maria Antonietta Belisario, Dario Gallotta, Sandro De Falco, Ivana Apicella, Sergio Rosselli, Maurizio Bruno
المساهمون: Cotugno, R, Gallotta, D, Dal Piaz, F, Apicella, I, De Falco, S, Rosselli, S, Bruno, M, Belisario, M A
المصدر: Biochimica et biophysica acta. G, General subjects
1840 (2014): 1135–1144. doi:10.1016/j.bbagen.2013.11.023
info:cnr-pdr/source/autori:Cotugno, Roberta; Gallotta, Dario; Dal Piaz, Fabrizio; Apicella, Ivana; De Falco, Sandro; Rosselli, Sergio; Bruno, Maurizio; Belisario, Maria Antonietta/titolo:Powerful tumor cell growth-inhibiting activity of a synthetic derivative of atractyligenin: Involvement of PI3K%2FAkt pathway and thioredoxin system/doi:10.1016%2Fj.bbagen.2013.11.023/rivista:Biochimica et biophysica acta. G, General subjects (Print)/anno:2014/pagina_da:1135/pagina_a:1144/intervallo_pagine:1135–1144/volume:1840مصطلحات موضوعية: Cell, Biophysics, Antineoplastic Agents, Apoptosis, Atractyloside, Biology, Cell cycle, Biochemistry, Jurkat cells, Mice, Phosphatidylinositol 3-Kinases, Thioredoxins, Tumor Cells, Cultured, medicine, Animals, Humans, MTT assay, Viability assay, Settore BIO/15 - Biologia Farmaceutica, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, PI3K/Akt, HCT 116 xenograft, Cytochromes c, Apoptosi, Thioredoxin system, Settore CHIM/06 - Chimica Organica, Xenograft Model Antitumor Assays, Cell biology, medicine.anatomical_structure, Caspases, Cancer research, Thioredoxin, Diterpenes, Kaurane, Proto-Oncogene Proteins c-akt, Ent-kaurane
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a94b63f0e7f9530e9e97f81d2c3533Test
http://hdl.handle.net/10447/96985Test -
9
المؤلفون: Monica Vitale, Concetta Ambrosino, Marzia Scarfò, Alfonso Baldi, Branka Radic, Lucia Altucci, Marco Miceli, Francesca Petraglia, Nicola Zambrano, Roberta Menafra, Sandro De Falco, Eduardo J. Patriarca, Gianluigi Franci, Gabriella Minchiotti, Hendrik G. Stunnenberg, Laura Casalino, Valeria Tarallo, Gabriella Pocsfalvi
المساهمون: Franci, G, Casalino, L, Petraglia, F, Miceli, M, Menafra, R, Radic, B, Tarallo, V, Vitale, M, Scarfò, M, Pocsfalvi, G, Baldi, Alfonso, Ambrosino, C, Zambrano, N, Patriarca, E, De Falco, S, Minchiotti, G, Stunnenberg, Hg, Altucci, Lucia, G., Franci, L., Casalino, F., Petraglia, M., Miceli, R., Menafra, B., Radic, V., Tarallo, Vitale, Monica, M., Scarfo, G., Pocsfalvi, A., Baldi, C., Ambrosino, Zambrano, Nicola, E., Patriarca, S., De Falco, G., Minchiotti, H. G., Stunnenberg, L., Altucci
المصدر: Biology Open, 2, 1070-7
Biology Open
Biology open 2 (2013): 1070–1077. doi:10.1242/bio.20135587
info:cnr-pdr/source/autori:Franci G, Casalino L, Petraglia F, Miceli M, Menafra R, Radic B, Tarallo V, Vitale M, Scarfò M, Pocsfalvi G, Baldi A, Ambrosino C, Zambrano N, Patriarca E, De Falco S, Minchiotti G, Stunnenberg HG, Altucci L./titolo:The class I-specific HDAC inhibitor MS-275 modulates the differentiation potential of mouse embryonic stem cells./doi:10.1242%2Fbio.20135587/rivista:Biology open/anno:2013/pagina_da:1070/pagina_a:1077/intervallo_pagine:1070–1077/volume:2
Biology Open, 2, 10, pp. 1070-7
Biology Open, Vol 2, Iss 10, Pp 1070-1077 (2013)مصطلحات موضوعية: QH301-705.5, medicine.drug_class, Science, Biology, Bioinformatics, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine, Epigenetics, Biology (General), Molecular Biology, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), reproductive and urinary physiology, 030304 developmental biology, 0303 health sciences, Stem cell, Entinostat, Histone deacetylase inhibitor, HDACi, Epigenetic, Embryonic stem cell, In vitro, Cell biology, chemistry, Teratocarcinoma, 030220 oncology & carcinogenesis, embryonic structures, General Agricultural and Biological Sciences, Research Article
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1329063188432ac2aaf9795e8d1a0cc3Test
http://hdl.handle.net/11591/182333Test -
10
المؤلفون: Sandro De Falco, Lucio Pastore, Teresa Riccioni, Valeria Tarallo, Maria Teresa Esposito, Augusto Orlandi, Onofrio Capasso, Claudio Pisano, Loredana Vesci
المساهمون: Tarallo, V, Vesci, L, Capasso, O, Esposito, MARIA TERESA, Riccioni, T, Pastore, Lucio, Orlandi, A, Pisano, C, De Falco, S.
المصدر: Cancer research (Chic. Ill.) 70 (2010): 1804–1813. doi:10.1158/0008-5472.CAN-09-2609
info:cnr-pdr/source/autori:Tarallo V.; Vesci L.; Capasso O.; Esposito M.T.; Riccioni T.; Pastore L.; Orlandi A.; Pisano C. and De Falco S./titolo:A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization/doi:10.1158%2F0008-5472.CAN-09-2609/rivista:Cancer research (Chic. Ill.)/anno:2010/pagina_da:1804/pagina_a:1813/intervallo_pagine:1804–1813/volume:70مصطلحات موضوعية: Placental growth factor, PlGF variant, Vascular Endothelial Growth Factor A, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Angiogenesis, Genetic enhancement, Cell, Nude, Mice, Nude, Biology, Settore MED/08 - Anatomia Patologica, Transfection, VEGF family, Cell Line, Neovascularization, chemistry.chemical_compound, Mice, Internal medicine, Cell Line, Tumor, medicine, Animals, Humans, Ovarian Neoplasms, Dimerization, Vascular Endothelial Growth Factor Receptor-1, Membrane Proteins, Protein Binding, Xenograft Model Antitumor Assays, Neovascularization, Pathologic, Female, Pathologic, Tumor, gene therapy, Vascular endothelial growth factor, Vascular endothelial growth factor A, Endocrinology, medicine.anatomical_structure, VEGF/PlGF heterodimer, Oncology, chemistry, Cancer research, medicine.symptom
وصف الملف: STAMPA
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67b825b34076092955a70f93060ef72eTest
http://hdl.handle.net/2108/42831Test