المؤلفون: Salvatore Cappabianca, Armando Calogero, Antonello Sica, Giuseppe Argenziano, Fortunato Ciardiello, Renato Franco, Concetta Anna Doraro, Andrea Ronchi, Alfonso Reginelli, Paola Vitiello, Francesco Pastore, Stefano Caccavale, Caterina Sagnelli

المساهمون: Sica, A., Vitiello, P., Caccavale, S., Sagnelli, C., Calogero, A., Anna Dodaro, C., Pastore, F., Ciardiello, F., Argenziano, G., Reginelli, A., Cappabianca, S., Franco, R., Ronchi, A., Dodaro, C.

المصدر: Open Medicine, Vol 15, Iss 1, Pp 119-125 (2020)
Open Medicine

مصطلحات موضوعية: Pathology, medicine.medical_specialty, leg-type lymphoma, Cutaneous lymphoma, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, Rare case, medicine, Neoplasm, cutaneous lymphoma, B-cell lymphoma, CD20, diffuse large b cell lymphoma, fish, biology, business.industry, Not Otherwise Specified, General Medicine, b-cell lymphoma, medicine.disease, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, Medicine, business, Diffuse large B-cell lymphoma, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25016ae5ea09b6d0cc6acb4f92e26acTest
https://doaj.org/article/c969b65ecde141bebcc7c6bc2bea994cTest

المؤلفون: Elisena Franzese, Bruno Daniele, Michele Orditura, Francesca Carlino, Luigi Pio Guerrera, A. Diana, Fortunato Ciardiello, Vincenzo Di Lauro, Emilio Francesco Giunta

المساهمون: Diana, A., Carlino, F., Giunta, E. F., Franzese, E., Guerrera, L. P., Di Lauro, V., Ciardiello, F., Daniele, B., Orditura, M.

المصدر: Current Treatment Options in Oncology

مصطلحات موضوعية: Oncology, Endocrine therapy, medicine.medical_specialty, medicine.drug_class, Fracture risk, Osteoporosis, Antineoplastic Agents, Breast Neoplasms, 030209 endocrinology & metabolism, Fractures, Bone, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Bone Density, Internal medicine, Bone mineral density, Humans, Medicine, Bisphosphonate, Pharmacology (medical), Breast Cancer (WJ Gradishar, Section Editor), Aromatase, Adverse effect, Aromatase inhibitor, Bone Density Conservation Agents, Diphosphonates, biology, Aromatase Inhibitors, business.industry, Cancer, Bisphosphonates, medicine.disease, Clinical trial, Denosumab, 030220 oncology & carcinogenesis, biology.protein, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac44cad5195e4d382d33cb18cd4744bTest
http://hdl.handle.net/11591/452988Test

المؤلفون: Floriana Morgillo, Carminia Maria Della Corte, Salvatore Cappabianca, Raimondo Di Liello, Francesca Sparano, Domenico Testa, Francesca Doria, Giuseppe Viscardi, Anna Castrichino, Maria Lucia Iacovino, Fernando Paragliola, Fortunato Ciardiello, Giuseppe Colella, Antonello Sica, Morena Fasano, Gaetano Motta, Giampaolo Tartaro

المساهمون: Fasano, M., Della Corte, C. M., Viscardi, G., Di Liello, R., Paragliola, F., Sparano, F., Iacovino, M. L., Castrichino, A., Doria, F., Sica, A., Morgillo, F., Colella, G., Tartaro, G., Cappabianca, S., Testa, D., Motta, G., Ciardiello, F.

المصدر: Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology, Vol 13 (2021)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, medicine.medical_treatment, EGFR, Review, lcsh:RC254-282, HNSCC, Targeted therapy, Internal medicine, cetuximab, medicine, Epidermal growth factor receptor, Cetuximab, biology, business.industry, Standard treatment, Head and neck cancer, Cancer, Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Radiation therapy, HNC, biology.protein, immunotherapy, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfca2c71f584f9b29b734d13d15364d5Test
http://hdl.handle.net/11591/453001Test

المؤلفون: Erika Martinelli, Teresa Troiani, Stefania Napolitano, Fortunato Ciardiello

المساهمون: Napolitano, S., Troiani, T., Martinelli, E., Ciardiello, F.

المصدر: ESMO Open

مصطلحات موضوعية: Cancer Research, Mutation, biology, business.industry, Colorectal cancer, Cancer, medicine.disease_cause, Precision medicine, medicine.disease, Immune system, Editorial, Oncology, Cancer cell, Cancer research, biology.protein, Medicine, Tensin, Humans, Epidermal growth factor receptor, Neoplasm Metastasis, Precision Medicine, business, Colorectal Neoplasms, metastatic CRC

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b4095c6bd7fd18863d61edcfd2d798Test
http://europepmc.org/articles/PMC7174008Test

المؤلفون: Teresa Troiani, Giulia Martini, F. De Vita, Claudia Cardone, Tiziana Latiano, Fortunato Ciardiello, Evaristo Maiello, Nicola Normanno, Erika Martinelli, Anna Maria Rachiglio, Pietro Paolo Vitiello, Davide Ciardiello

المساهمون: Martinelli, E., Ciardiello, D., Martini, G., Troiani, T., Cardone, C., Vitiello, P. P., Normanno, N., Rachiglio, A. M., Maiello, E., Latiano, T., De Vita, F., Ciardiello, F.

مصطلحات موضوعية: 0301 basic medicine, Oncology, medicine.medical_specialty, Colorectal cancer, Cetuximab, Antineoplastic Agents, Translational research, Context (language use), medicine.disease_cause, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, anti-epidermal growth factor receptor monoclonal antibodie, 0302 clinical medicine, Internal medicine, medicine, Humans, Panitumumab, Epidermal growth factor receptor, Liquid biopsy, predictive biomarker, molecular selection, biology, liquid biopsy, business.industry, metastatic colorectal cancer, rechallenge therapy, Hematology, medicine.disease, digestive system diseases, ErbB Receptors, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, biology.protein, KRAS, Colorectal Neoplasms, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc1e2145074e4fd31c7a3f556eb19eaTest
http://hdl.handle.net/11591/427752Test

المؤلفون: L. Poliero, Pietro Paolo Vitiello, P. Vitale, N. Zanaletti, V. Caputo, Francesca Marrone, Vincenzo Famiglietti, Claudia Cardone, Emilio Francesco Giunta, Teresa Troiani, C. Borrelli, Vincenzo De Falco, Alessandra Di Liello, Fortunato Ciardiello, M. Terminiello, Erika Martinelli, Michele Caraglia, Valentina Mattera Iacono, Renato Franco, Stefania Napolitano, G. Arrichiello, Ferdinando De Vita, Giulia Martini, Floriana Morgillo, Davide Ciardiello, Angela Lombardi

المساهمون: Vitiello, P. P., De Falco, V., Giunta, E. F., Ciardiello, D., Cardone, C., Vitale, P., Zanaletti, N., Borrelli, C., Poliero, L., Terminiello, M., Arrichiello, G., Caputo, Vincenzo, Famiglietti, V., Iacono, V. M., Marrone, F., Di Liello, A., Martini, G., Napolitano, S., Caraglia, M., Lombardi, A., Franco, R., De Vita, F., Morgillo, F., Troiani, T., Ciardiello, F., Martinelli, E.

المصدر: Cancers
Volume 11
Issue 10
Cancers (Basel) 11 (2019). doi:10.3390/cancers11101504
info:cnr-pdr/source/autori:Vitiello P.P.; De Falco V.; Giunta E.F.; Ciardiello D.; Cardone C.; Vitale P.; Zanaletti N.; Borrelli C.; Poliero L.; Terminiello M.; Arrichiello G.; Caputo V.; Famiglietti V.; Iacono V.M.; Marrone F.; Di Liello A.; Martini G.; Napolitano S.; Caraglia M.; Lombardi A.; Franco R.; De Vita F.; Morgillo F.; Troiani T.; Ciardiello F.; Martinelli E./titolo:Clinical practice use of liquid biopsy to identify RAS%2FBRAF mutations in patients with metastatic colorectal cancer (mCRC): A single institution experience/doi:10.3390%2Fcancers11101504/rivista:Cancers (Basel)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:11
Cancers, Vol 11, Iss 10, p 1504 (2019)

مصطلحات موضوعية: ras testing, 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Oncology, Cancer Research, medicine.medical_specialty, Colorectal cancer, RAS testing, acquired resistance, anti-EGFR, clonal evolution, colorectal cancer, liquid biopsy, Concordance, medicine.disease_cause, lcsh:RC254-282, Somatic evolution in cancer, Article, 03 medical and health sciences, 0302 clinical medicine, Carcinoembryonic antigen, Growth factor receptor, Internal medicine, medicine, Liquid biopsy, biology, business.industry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, KRAS, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01baab59a4935313655b401519802669Test

المؤلفون: Andrea Bertotti, Davide Ciardiello, Nunzia Matrone, Valentina Belli, Floriana Morgillo, Vincenzo De Falco, Erika Martinelli, Emilio Francesco Giunta, Fortunato Ciardiello, Livio Trusolino, Stefania Napolitano, Umberto Bracale, Giorgia Migliardi, Francesca Cottino, Teresa Troiani

المساهمون: Belli, V., Matrone, N., Napolitano, S., Migliardi, G., Cottino, F., Bertotti, A., Trusolino, L., Martinelli, E., Morgillo, F., Ciardiello, D., De Falco, V., Giunta, E. F., Bracale, U., Ciardiello, F., Troiani, T.

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-14 (2019)
Journal of Experimental & Clinical Cancer Research : CR
Journal of experimental & clinical cancer research (Online) 38 (2019). doi:10.1186/s13046-019-1230-z
info:cnr-pdr/source/autori:Belli V.; Matrone N.; Napolitano S.; Migliardi G.; Cottino F.; Bertotti A.; Trusolino L.; Martinelli E.; Morgillo F.; Ciardiello D.; De Falco V.; Giunta E.F.; Bracale U.; Ciardiello F.; Troiani T./titolo:Combined blockade of MEK and PI3KCA as an effective antitumor strategy in HER2 gene amplified human colorectal cancer models/doi:10.1186%2Fs13046-019-1230-z/rivista:Journal of experimental & clinical cancer research (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:38

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Neuroblastoma RAS viral oncogene homolog, MAP Kinase Kinase Kinase, Cancer Research, Transcription Factor, Receptor, ErbB-2, Colorectal cancer, Colorectal Neoplasm, medicine.disease_cause, Antineoplastic Agent, Mice, 0302 clinical medicine, Epidermal growth factor receptor, skin and connective tissue diseases, Nuclear Protein, Cetuximab, biology, Nuclear Proteins, MAP Kinase Kinase Kinases, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, HER2-amplified cancer, MEK and PI3KCA inhibitors, xenografts, patient-derived xenografts, Oncology, 030220 oncology & carcinogenesis, Female, Pertuzumab, KRAS, Colorectal Neoplasms, Human, medicine.drug, patient-derived xenograft, Xenograft Model Antitumor Assay, MEK and PI3KCA inhibitor, Protein Kinase Inhibitor, Antineoplastic Agents, Lapatinib, lcsh:RC254-282, 03 medical and health sciences, Cell Line, Tumor, Biomarkers, Tumor, medicine, Animals, Humans, xenograft, Protein Kinase Inhibitors, neoplasms, Dose-Response Relationship, Drug, Animal, business.industry, Research, Gene Amplification, medicine.disease, Xenograft Model Antitumor Assays, Disease Models, Animal, 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, biology.protein, business, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9733a5819c767c28da3e589680e637b3Test
https://doi.org/10.1186/s13046-019-1230-zTest

المؤلفون: Alfonso Fiorelli, Erika Martinelli, Giusi Barra, Marianna Abate, Mario Santini, Teresa Troiani, Giovanni Vicidomini, Michele Caraglia, Carminia Maria Della Corte, Amalia Luce, Floriana Morgillo, Silvia Zappavigna, Raimondo Di Liello, Fortunato Ciardiello, Vincenza Ciaramella

المساهمون: Della Corte, C. M., Barra, G., Ciaramella, V., Di Liello, R., Vicidomini, G., Zappavigna, S., Luce, A., Abate, M., Fiorelli, A., Caraglia, M., Santini, M., Martinelli, E., Troiani, T., Ciardiello, F., Morgillo, F.

المصدر: Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-12 (2019)
Journal of Experimental & Clinical Cancer Research : CR

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, PD-L1, Cancer Research, Lung Neoplasms, T-Lymphocytes, medicine.medical_treatment, Lymphocyte Activation, lcsh:RC254-282, B7-H1 Antigen, Targeted therapy, Organoid cultures, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Immune system, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Spheroids, Cellular, Tumor Cells, Cultured, Tumor Microenvironment, Organoid culture, Humans, Medicine, Aniline Compounds, Acrylonitrile, biology, business.industry, Research, Immunotherapy, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, MEK, 030104 developmental biology, Cytokine, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, Cytokine secretion, Lung cancer, business, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947aeb243c1693ebde2eb2b1fe19777aTest
http://hdl.handle.net/11591/416365Test

المؤلفون: Maria Furia, Teresa Troiani, Fortunato Ciardiello, A. L. Muddassir, Floriana Morgillo, V. De Falco, Alexey V. Sorokin, Stefania Napolitano, Emilio Francesco Giunta, Valentina Belli, Erika Martinelli, Giulia Martini, Scott Kopetz, Davide Ciardiello, Nunzia Matrone

المساهمون: Institut Català de la Salut, [Napolitano S] Medical Oncology Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80100 Naples, Italy. Department of Gastrointestinal Medical Oncology, Division of Cancer Medicin0065, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. [Matrone N] Medical Oncology Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80100 Naples, Italy. Medical University of Vienna, Institute for Cancer Research, Borschkegasse 8A, 1090 Wien, Austria. [Muddassir AL, Sorokin A] Department of Gastrointestinal Medical Oncology, Division of Cancer Medicin0065, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. [Martini G] Medical Oncology Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80100 Naples, Italy. Gastrointestinal and neuroendocrine tumor group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [De Falco V] Medical Oncology Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80100 Naples, Italy, Hospital Universitari Vall d'Hebron, Napolitano, S., Matrone, N., Muddassir, A. L., Martini, G., Sorokin, A., De Falco, V., Giunta, E. F., Ciardiello, D., Martinelli, E., Belli, V., Furia, M., Kopetz, S., Morgillo, F., Ciardiello, F., Troiani, T., Vall d'Hebron Barcelona Hospital Campus

المصدر: Journal of experimental & clinical cancer research (Online) 38 (2019). doi:10.1186/s13046-019-1497-0
info:cnr-pdr/source/autori:Napolitano S.; Matrone N.; Muddassir A.L.; Martini G.; Sorokin A.; De Falco V.; Giunta E.F.; Ciardiello D.; Martinelli E.; Belli V.; Furia M.; Kopetz S.; Morgillo F.; Ciardiello F.; Troiani T./titolo:Triple blockade of EGFR, MEK and PD-L1 has antitumor activity in colorectal cancer models with constitutive activation of MAPK signaling and PD-L1 overexpression/doi:10.1186%2Fs13046-019-1497-0/rivista:Journal of experimental & clinical cancer research (Online)/anno:2019/pagina_da:/pagina_a:/intervallo_pagine:/volume:38
Scientia
Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-18 (2019)
Journal of Experimental & Clinical Cancer Research : CR

مصطلحات موضوعية: 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, Cancer Research, Colorectal cancer, medicine.disease_cause, B7-H1 Antigen, 0302 clinical medicine, Còlon - Càncer, MEK inhibitor resistance, PD-L1 inhibitors, EGFR inhibitors, Sulfonamides, biology, Otros calificadores::Otros calificadores::/genética [Otros calificadores], MEK inhibitor, Antibodies, Monoclonal, MAP Kinase Kinase Kinases, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales [ENFERMEDADES], ErbB Receptors, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Recte - Càncer, Female, KRAS, Colorectal Neoplasms, Epithelial-Mesenchymal Transition, Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm [PHENOMENA AND PROCESSES], MAP Kinase Signaling System, lcsh:RC254-282, Erlotinib Hydrochloride, 03 medical and health sciences, Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [DISEASES], Cell Line, Tumor, PD-L1, medicine, Other subheadings::Other subheadings::/genetics [Other subheadings], Humans, Resistència als medicaments, fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos [FENÓMENOS Y PROCESOS], Research, Diphenylamine, Cancer, Gene signature, HCT116 Cells, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Drug Resistance, Neoplasm, biology.protein, Cancer research

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c37e635a06daf36c9b2902636b96a0eTest
http://www.cnr.it/prodotto/i/418700Test

المؤلفون: Rosa Marina Melillo, Vincenzo Rosario Iaffaioli, Anna Nappi, Teresa Troiani, Gerardo Botti, Giuseppina Liguori, Floriana Morgillo, Claudia Cardone, Fortunato Ciardiello, Liberato Berrino, Federica Liotti, Stefania Napolitano, Davide Ciardiello, Giulia Martini, Fiorella Angelica Valeria Ferraiolo, Barbara Rinaldi, Loreta Pia Ciuffreda, Roberto Bianco, Donata Vitagliano, Erika Martinelli

المساهمون: Martinelli, Erika, Martini, G, Cardone, C, Troiani, Teresa, Liguori, G, Vitagliano, D, Napolitano, S, Morgillo, Floriana, Rinaldi, Barbara, Melillo, Rm, Liotti, F, Nappi, A, Bianco, R, Berrino, Liberato, Ciuffreda, Lp, Ciardiello, D, Iaffaioli, V, Botti, G, Ferraiolo, F, Ciardiello, F., Martini, Giulia, Cardone, Claudia, Liguori, Giuseppina, Vitagliano, Donata, Napolitano, Stefania, Melillo, ROSA MARINA, Liotti, Federica, Nappi, Anna, Bianco, Roberto, Ciuffreda, Loreta Pia, Ciardiello, Davide, Iaffaioli, Vincenzo, Botti, Gerardo, Ferraiolo, Fiorella, Ciardiello, Fortunato

المصدر: Oncotarget
Europe PubMed Central
Oncotarget 6 (2015): 23281–23296. doi:10.18632/oncotarget.3962
info:cnr-pdr/source/autori:Martinelli, Erika; Martini, Giulia; Cardone, Claudia; Troiani, Teresa; Liguori, Giuseppina; Vitagliano, Donata; Napolitano, Stefania; Morgillo, Floriana; Rinaldi, Barbara; Melillo, Rosa Marina; Liotti, Federica; Nappi, Anna; Bianco, Roberto; Berrino, Liberato; Ciuffreda, Loreta Pia; Ciardiello, Davide; Iaffaioli, Vincenzo; Botti, Gerardo; Ferraiolo, Fiorella; Ciardiello, Fortunato/titolo:AXL is an oncotarget in human colorectal cancer/doi:10.18632%2Foncotarget.3962/rivista:Oncotarget/anno:2015/pagina_da:23281/pagina_a:23296/intervallo_pagine:23281–23296/volume:6

مصطلحات موضوعية: Male, Colorectal cancer, Angiogenesis, Receptor tyrosine kinase, chemistry.chemical_compound, Mice, Cell Movement, GAS6, Anilides, In Situ Hybridization, Fluorescence, Oligonucleotide Array Sequence Analysis, Aged, 80 and over, Mice, Inbred BALB C, Neovascularization, Pathologic, Middle Aged, Immunohistochemistry, Oncology, Quinolines, Intercellular Signaling Peptides and Proteins, Female, RNA Interference, Colorectal Neoplasms, Adult, foretinib, Cell Survival, Mice, Nude, colorectal cancer, Antineoplastic Agents, Biology, FISH, Cell Line, Tumor, Proto-Oncogene Proteins, Pathology Section, medicine, Gene silencing, Animals, Humans, Gene Silencing, neoplasms, Aged, Cell Proliferation, Cell growth, Foretinib, AXL, Receptor Protein-Tyrosine Kinases, medicine.disease, HCT116 Cells, Axl Receptor Tyrosine Kinase, digestive system diseases, Research Paper: Pathology, chemistry, Cancer research, biology.protein, Neoplasm Transplantation

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c3a58af6c1e8909557c8cca4cb94a0Test
http://europepmc.org/articles/PMC4695118Test