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المؤلفون: Ju-Sheng Zheng, Lukas Schwingshackl, Karina Meidtner, Stefan Dietrich, Simone Jacobs, Matthias B. Schulze
المصدر: Obesity Reviews
مصطلحات موضوعية: Endocrinology, Diabetes and Metabolism, Population, MEDLINE, physical activity, 030209 endocrinology & metabolism, Type 2 diabetes, Bioinformatics, Polymorphism, Single Nucleotide, ABCC8, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Ethnicity, medicine, Humans, Genetic Predisposition to Disease, Prospective Studies, 030212 general & internal medicine, education, Prospective cohort study, weight loss intervention, education.field_of_study, biology, business.industry, Incidence (epidemiology), Public Health, Environmental and Occupational Health, Genetic Variation, medicine.disease, HNF1B, incident type 2 diabetes, Diabetes Mellitus, Type 2, gene‐lifestyle interaction, Diet, Western, biology.protein, Gene-Environment Interaction, Genetics/Obesity Comorbidity, Diet, Healthy, diet, business, Transcription Factor 7-Like 2 Protein, TCF7L2, Genome-Wide Association Study
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786e4fe02d1ec2736543aba482181f2bTest
https://doi.org/10.1111/obr.12921Test -
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المؤلفون: Aida Martinez-Sanchez, Gabriela da Silva Xavier, Isabelle Leclerc, Marie-Sophie Nguyen-Tu, Guy A. Rutter
المصدر: Diabetologia
مصطلحات موضوعية: 0301 basic medicine, Male, Mouse, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Adipose tissue, Gene Expression, Type 2 diabetes, Fatty Acids, Nonesterified, Impaired glucose tolerance, chemistry.chemical_compound, Mice, 0302 clinical medicine, Adipocyte, Insulin-Secreting Cells, Insulin Secretion, Adipocytes, Glucose homeostasis, Insulin, Mice, Knockout, Incretin, Beta cell, Body Composition, Female, Transcription Factor 7-Like 2 Protein, medicine.medical_specialty, Diabetes risk, 030209 endocrinology & metabolism, Biology, Fatty Acid-Binding Proteins, Incretins, Article, 03 medical and health sciences, Internal medicine, Glucose Intolerance, Internal Medicine, medicine, Animals, Integrases, medicine.disease, Lipid Metabolism, Fatty acid, Mice, Inbred C57BL, TCF7L2, 030104 developmental biology, Endocrinology, Glucose, chemistry
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5fee8cd332eb1d2a6a5a2ea0a9c9d11Test
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3Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
المؤلفون: Peter Orchard, Jocelyn E. Manning Fox, Anthony Payne, Karen L. Mohlke, Laura J. Scott, Nikolay Oskolkov, Anubha Mahajan, Andrew A. Brown, Apoorva K Iyengar, Paul Johnson, Ola Hansson, Patrick E. MacDonald, Michael L. Stitzel, Ulrika Krus, Ana Viñuela, Cédric Howald, Narisu Narisu, Gad Hatem, Anna L. Gloyn, Nikolaos I Panousis, Michael R. Erdos, Leif Groop, Vibe Nylander, Olof Asplund, João Fadista, Francis S. Collins, Emmanouil T. Dermitzakis, Amanda J. Bennett, Swarooparani Vadlamudi, Arushi Varshney, Rashmi B. Prasad, Stephen C. J. Parker, Mark I. McCarthy, Michael Boehnke, Martijn van de Bunt, Ryan P. Welch
المساهمون: Brown, Andrew Anand, Howald, Cédric, Panousis, Nikolaos, Dermitzakis, Emmanouil, Institute for Molecular Medicine Finland, University of Helsinki, Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, University Management
المصدر: Nature Communications, Vol. 11, No 1 (2020) P. 4912
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)مصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, endocrine system diseases, General Physics and Astronomy, Genome-wide association study, Cohort Studies, Mice, 0302 clinical medicine, ddc:590, Transcriptional regulation, 80 and over, ddc:576.5, RNA-Seq, lcsh:Science, Genetics, Regulation of gene expression, Aged, 80 and over, ARCHITECTURE, Multidisciplinary, geography.geographical_feature_category, Tumor, 1184 Genetics, developmental biology, physiology, Type 2 diabetes, Single Nucleotide, Middle Aged, Islet, OPEN CHROMATIN, Transcription Factor 7-Like 2 Protein/genetics/metabolism, medicine.anatomical_structure, Enhancer Elements, Genetic, Regulatory sequence, Blood Glucose/genetics/metabolism, Female, Islets of Langerhans/metabolism, MESSENGER-RNA, Transcription Factor 7-Like 2 Protein, Sequence Analysis, Type 2/blood/genetics, Adult, BETA-CELL LINE, Diacylglycerol Kinase, endocrine system, Adolescent, Enhancer Elements, Science, Quantitative Trait Loci, Biology, INSULIN-SECRETION, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, 03 medical and health sciences, Islets of Langerhans, Young Adult, Genetic, Cell Line, Tumor, medicine, GLYCEMIC TRAITS, Diabetes Mellitus, Animals, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, Polymorphism, SIGNATURES, Genetic association study, Aged, CAUSAL VARIANTS, geography, Pancreatic islets, Data acquisition, General Chemistry, Sequence Analysis, DNA, DNA, Gene regulation, 030104 developmental biology, Diabetes Mellitus, Type 2, Gene Expression Regulation, Diacylglycerol Kinase/genetics/metabolism, Expression quantitative trait loci, lcsh:Q, TYPE-2 DIABETES RISK, 3111 Biomedicine, TCF7L2, 030217 neurology & neurosurgery, Genome-Wide Association Study
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a13e4756f7dc1e58a1b08e7a9f4874Test
https://archive-ouverte.unige.ch/unige:144670Test -
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المؤلفون: Daniel F. Gudbjartsson, Fereidoun Azizi, Erna V. Ivarsdottir, Isleifur Olafsson, Unnur Thorsteinsdottir, Valgerdur Steinthorsdottir, Olof Sigurdardottir, Rafn Benediktsson, Gudmar Thorleifsson, Gudmundur I. Eyjolfsson, Astradur B. Hreidarsson, Hilma Holm, Maryam S. Daneshpour, Arni V Thorsson, Kari Stefansson, Ragnar Bjarnason, Patrick Sulem, Sirous Zeinali, Gunnar Sigurdsson, Snaevar Sigurdsson
المصدر: Nature Genetics. 49:1398-1402
مصطلحات موضوعية: Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Iceland, Penetrance, Type 2 diabetes, Polymorphism, Single Nucleotide, Body Mass Index, 03 medical and health sciences, Gene Frequency, Risk Factors, Internal medicine, Glucokinase, Genetics, medicine, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Alleles, Glycated Hemoglobin, biology, Genetic Variation, Fasting, Heritability, medicine.disease, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Glucose-6-Phosphatase, biology.protein, Female, Transcription Factor 7-Like 2 Protein, TCF7L2, Body mass index, Glucose 6-phosphatase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f339bb65586e022663c8d5c487d6a8dTest
https://doi.org/10.1038/ng.3928Test -
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المؤلفون: Ayo P. Doumatey, Cristina Pomilla, Elizabeth H. Young, Anubha Mahajan, Mark I. McCarthy, Meng Sun, Ayesha A. Motala, Fraser J. Pirie, Guanjie Chen, Eleanor Wheeler, Ji Chen, Andrew P. Morris, Adebowale Adeyemo, Inês Barroso, Tommy Carstensen, Charles N. Rotimi, Manjinder S. Sandhu
المساهمون: Sandhu, Manjinder [0000-0002-2725-142X], Barroso, Ines [0000-0001-5800-4520], Wheeler, Eleanor [0000-0002-8616-6444], Apollo - University of Cambridge Repository
المصدر: Chen, J, Sun, M, Adeyemo, A, Pirie, F, Carstensen, T, Pomilla, C, Doumatey, A P, Chen, G, Young, E H, Sandhu, M, Morris, A P, Barroso, I, McCarthy, M I, Mahajan, A, Wheeler, E, Rotimi, C N & Motala, A A 2019, ' Genome-wide association study of type 2 diabetes in Africa ', Diabetologia, vol. 62, no. 7, pp. 1204-1211 . https://doi.org/10.1007/s00125-019-4880-7Test
DIABETOLOGIA
Diabetologiaمصطلحات موضوعية: 0301 basic medicine, Genome-wide association study, Genotyping Techniques, Endocrinology, Diabetes and Metabolism, Black People, 030209 endocrinology & metabolism, Locus (genetics), Type 2 diabetes, Biology, Genetic analysis, Polymorphism, Single Nucleotide, Article, White People, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic association, Genetics, Fine-mapping, medicine.disease, Genetic architecture, 3. Good health, Minor allele frequency, 030104 developmental biology, Diabetes Mellitus, Type 2, Africa, Established loci, TCF7L2, Transcription Factor 7-Like 2 Protein
وصف الملف: application/pdf; application/zip; text/xml
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26b9ac35fdee2e04abeed161169d97bTest
https://www.repository.cam.ac.uk/handle/1810/294957Test -
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المؤلفون: Hong-Wen Deng, Hao He, Hui Shen, Wei Zhu, Lan Zhang, Yu-Jie Yan, Yong Zeng
المصدر: J Hum Genet
مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Datasets as Topic, Gene Expression, Genome-wide association study, Single-nucleotide polymorphism, Type 2 diabetes, Comorbidity, 030105 genetics & heredity, Biology, Polymorphism, Single Nucleotide, Article, Body Mass Index, 03 medical and health sciences, Meta-Analysis as Topic, Pleiotropy, Genetics, Genetic Pleiotropy, medicine, Prevalence, Humans, Gene Regulatory Networks, Genetic Predisposition to Disease, Obesity, Genetics (clinical), Genetic Association Studies, Genetic association, Metabolic Syndrome, nutritional and metabolic diseases, Molecular Sequence Annotation, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 2, Metabolic syndrome, TCF7L2, Transcription Factor 7-Like 2 Protein, Genome-Wide Association Study
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cafdeaf2e0ed052655544b4a5c0e8eaTest
https://pubmed.ncbi.nlm.nih.gov/32948839Test -
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المصدر: Journal of cellular and molecular medicine. 2019. Vol. 23, № 2. P. 1628-1631
Journal of Cellular and Molecular Medicineمصطلحات موضوعية: 0301 basic medicine, Male, Genotype, endocrine system diseases, Short Communication, Population, Short Communications, Locus (genetics), Type 2 diabetes, Biology, ADIPOQ Gene, Polymorphism, Single Nucleotide, polymorphism, сахарный диабет 2-го типа, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, гены, medicine, ADIPOQ, Humans, Genetic Predisposition to Disease, KCNJ11, Allele, Potassium Channels, Inwardly Rectifying, education, gene, Kyrgyzstan, Alleles, Genetic Association Studies, Genetics, education.field_of_study, кыргызская популяция, Case-control study, nutritional and metabolic diseases, Cell Biology, medicine.disease, TCF7L2, 030104 developmental biology, Diabetes Mellitus, Type 2, Genetic marker, 030220 oncology & carcinogenesis, полиморфизм, Molecular Medicine, Female, type 2 diabetes, Adiponectin, Transcription Factor 7-Like 2 Protein
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe35d05cdc6d481af78739a89bae71efTest
http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000791243Test -
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المؤلفون: Ivana Gotthardová, Ivan Tkáč
المصدر: Pharmacogenomics. 17:795-804
مصطلحات موضوعية: 0301 basic medicine, endocrine system, Pharmacogenomic Variants, endocrine system diseases, Incretin, 030209 endocrinology & metabolism, Type 2 diabetes, Biology, Pharmacology, Incretins, Polymorphism, Single Nucleotide, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Chymotrypsin, Humans, Hypoglycemic Agents, Allele, Dipeptidyl-Peptidase IV Inhibitors, Type 2 Diabetes Mellitus, medicine.disease, Pharmacogenomic Testing, Minor allele frequency, 030104 developmental biology, Diabetes Mellitus, Type 2, KCNQ1 Potassium Channel, Molecular Medicine, Transcription Factor 7-Like 2 Protein, TCF7L2, Pharmacogenetics
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ed9a983504f61d4f1b6369f29f6c6fTest
https://doi.org/10.2217/pgs-2016-0011Test -
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المؤلفون: Cristina Barosa, Meera Shah, Robert A. Rizza, John G. Jones, Cátia Marques, Adrian Vella, Ron T. Varghese, Ivan Viegas
المصدر: Diabetes
ResearcherIDمصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Glucose uptake, 030209 endocrinology & metabolism, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Genetic Predisposition to Disease, Genetic Association Studies, Insulin, Middle Aged, Glucose clamp technique, medicine.disease, Metabolism, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Liver, Gluconeogenesis, Case-Control Studies, Glucose Clamp Technique, Female, Insulin Resistance, Transcription Factor 7-Like 2 Protein, TCF7L2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9731e5bd4ee00266d61765d9dacaaTest
https://doi.org/10.2337/db15-1593Test -
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المؤلفون: Angela Dardano, Giuseppe Daniele, Andrea Mari, Melania Gaggini, Cristina Bianchi, Giuseppina Basta, Mario Comassi, Amalia Gastaldelli, Stefano Del Prato, Roberto Miccoli
المصدر: The Journal of Clinical Endocrinology & Metabolism. 100:E1160-E1167
مصطلحات موضوعية: Blood Glucose, Male, Risk, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Incretin, Type 2 diabetes, Biology, INSULIN-SECRETION, POLYPEPTIDE, Polymorphism, Single Nucleotide, Biochemistry, Glucagon, MECHANISMS, Cohort Studies, chemistry.chemical_compound, Endocrinology, BETA-CELL FUNCTION, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, CARRIERS, POLYMORPHISMS, ASSOCIATION, PROINSULIN, INCRETIN, CATENIN, Glucose tolerance test, medicine.diagnostic_test, Insulin, Biochemistry (medical), Glucose Tolerance Test, Middle Aged, Postprandial Period, medicine.disease, Glucose, Postprandial, Diabetes Mellitus, Type 2, chemistry, Female, Glycated hemoglobin, Energy Metabolism, Transcription Factor 7-Like 2 Protein, TCF7L2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1184815f32e8d6fb0311b878e0eee611Test
https://doi.org/10.1210/jc.2015-1172Test