المؤلفون: Ling Fang, Zha-Jun Zhan, Yue-Jun Wang, You-Min Ying, Jian-Biao Yao, Fang-Jun Qiu, Wei-Guang Shan, Yuan-Yuan Li, Hang-Fei Yu

المصدر: Chemistry of Natural Compounds. 54:450-454

مصطلحات موضوعية: biology, Strain (chemistry), 010405 organic chemistry, Chemistry, Stereochemistry, Fungal endophyte, Plant Science, General Chemistry, Fungus, Huperzia serrata, 010402 general chemistry, biology.organism_classification, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, 0104 chemical sciences, HeLa, Ceriporia, chemistry.chemical_compound, Furan, Two-dimensional nuclear magnetic resonance spectroscopy

الوصف: The One Strain Many Compounds (OSMAC) method was employed to explore the chemical diversities of secondary metabolites produced by Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte of Huperzia serrata. Four new furan derivatives 1–4, together with a known compound, were obtained from the rice culture of the fungus. The structures of the new compounds were established by detailed analysis of the spectroscopic data, especially 1D and 2D NMR, and HR-ESI-MS. All compounds were evaluated for their acetylcholinesterase inhibitory activity and antiproliferative activities against HeLa, HepG2, and SGC7901 cell lines.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4887bf038dfb1e8f6591153645971f60Test
https://doi.org/10.1007/s10600-018-2377-0Test

المؤلفون: Lie-Feng Ma, You-Min Ying, Jian-Biao Yao, Zha-Jun Zhan, Wei-Guang Shan, Wei-Wei Pang, Ling Fang, Yuan-Yuan Li, Hao-Ying Qian, Yang Zheng

المصدر: Journal of Chemical Research. 41:262-265

مصطلحات موضوعية: 0301 basic medicine, Xenorhabdus indica, Natural product, biology, 010405 organic chemistry, Stereochemistry, Absolute configuration, General Chemistry, medicine.disease_cause, biology.organism_classification, 01 natural sciences, In vitro, 0104 chemical sciences, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Product (mathematics), medicine, Density functional theory, Two-dimensional nuclear magnetic resonance spectroscopy, Bacteria

الوصف: Three new compounds, xenorine A-C, along with six known compounds were isolated from the cultured broth of Xenorhabdus indica. The chemical structures of these compounds were elucidated mainly by analysis of 1D and 2D NMR and MS data. The major metabolites were dioxopiperazines. In addition, 5,6,11,11a-tetrahydro-1 H-imidazo[1′,5′:1,6]pyrido[3,4- b]indole-1,3(2 H)-dione, previously described as synthetic product, was isolated as a natural product. The absolute configuration was determined using quantum chemical time-dependent density functional theory calculations. The six known compounds showed weak in vitro immunosuppressive activity towards concanavalin-A- and lipopolysaccharide -induced proliferation of mice splenocytes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a874055eda852162f3de5865c7be24b1Test
https://doi.org/10.3184/174751917x14925986241016Test

المؤلفون: Brian K. Nicholson, Dennis P. Gordon, Biao Yao, Michèle R. Prinsep

المصدر: Journal of natural products. 66(8)

مصطلحات موضوعية: Stereochemistry, Molecular Conformation, Pharmaceutical Science, Antineoplastic Agents, Biology, Pharmacognosy, Crystallography, X-Ray, Animal origin, Bryozoa, Analytical Chemistry, Alkaloids, Anti-Infective Agents, Drug Discovery, Animals, Spectral analysis, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, Antitumor activity, Molecular Structure, Alkaloid, Nouvelle zelande, Organic Chemistry, Biological activity, Antimicrobial, Complementary and alternative medicine, Biochemistry, Molecular Medicine, Drug Screening Assays, Antitumor, Heterocyclic Compounds, 3-Ring, New Zealand

الوصف: Two new alkaloids, pterocellins A and B, have been isolated from the New Zealand marine bryozoan Pterocella vesiculosa. Structural elucidation was achieved through NMR and mass spectral analysis in conjunction with a single-crystal X-ray diffraction study of pterocellin A. The pterocellins possess a novel heterocyclic skeleton and exhibit potent antitumor activity and antimicrobial activity in vitro but only modest activity in the in vivo hollow fiber assay at the National Cancer Institute.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f076966046a2f1675e391ac0a2507d0fTest
https://pubmed.ncbi.nlm.nih.gov/12932127Test