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المؤلفون: Andrea Sinz, Nina Braun, Stephan A. Pless, Christian Ihling, Søren Friis, Jacob Andersen
المصدر: Braun, N, Friis, S, Ihling, C, Sinz, A, Andersen, J & Pless, S A 2021, ' High-throughput characterization of photocrosslinker-bearing ion channel variants to map residues critical for function and pharmacology ', PLOS Biology, vol. 19, no. 9, e3001321 . https://doi.org/10.1371/journal.pbio.3001321Test
PLoS Biology, Vol 19, Iss 9, p e3001321 (2021)
PLoS Biologyمصطلحات موضوعية: Atmospheric Science, Physiology, Spider Venoms, Biochemistry, Physical Chemistry, Ion Channels, Spectrum Analysis Techniques, Automated patch clamp, Animal Cells, Medicine and Health Sciences, Cross-Linking, Amino Acids, Biology (General), Receptor, Membrane Electrophysiology, Throughput (business), chemistry.chemical_classification, Fluorescence-Activated Cell Sorting, Chemistry, Physics, General Neuroscience, Methods and Resources, Transfection, Characterization (materials science), Amino acid, Electrophysiology, Bioassays and Physiological Analysis, Spectrophotometry, Physical Sciences, Cytophotometry, Cellular Types, Protons, General Agricultural and Biological Sciences, QH301-705.5, Immune Cells, Immunology, Biophysics, Antigen-Presenting Cells, Neurophysiology, Computational biology, Biology, Research and Analysis Methods, General Biochemistry, Genetics and Molecular Biology, Humans, Environmental Chemistry, Patch clamp, Molecular Biology Techniques, Molecular Biology, Ion channel, Nuclear Physics, Nucleons, Chemical Bonding, General Immunology and Microbiology, Ecology and Environmental Sciences, Electrophysiological Techniques, Biology and Life Sciences, Proteins, Cell Biology, Acid Sensing Ion Channels, HEK293 Cells, Atmospheric Chemistry, Earth Sciences, Peptides, Acid Deposition, Patch Clamp Techniques, Function (biology), Neuroscience
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47ac6c5162cc821f06ca74915038c50Test
https://doi.org/10.1101/2020.11.24.392498Test -
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المؤلفون: Claudia Haarmann, Max Mueller, Juergen Steindl, Alison Obergrussberger, Andrea Brüggemann, Johannes Stiehler, Atsushi Ohtsuki, Niels Fertig, Nadine Becker, Marius Vogel, Tom A. Goetze, Ilka Rinke, Michael George, Takayuki Oka, Timo Stengel, Markus Rapedius
المصدر: SLAS Technology. 21:779-793
مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, Materials science, hERG, Receptors, Cell Surface, Ion Channels, Cell Line, 03 medical and health sciences, Automated patch clamp, Electronic engineering, Animals, Humans, Patch clamp, Ion channel, Automation, Laboratory, Voltage-gated ion channel, biology, Amplifier, Pipette, Robotics, High-Throughput Screening Assays, Computer Science Applications, Medical Laboratory Technology, 030104 developmental biology, biology.protein, Ligand-gated ion channel, Biomedical engineering
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20c31bb0ac574bd86f5dc089b001c3acTest
https://doi.org/10.1177/2211068215623209Test -
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المؤلفون: Michael M. Poe, Nina Y. Yuan, Christopher M. Witzigmann, Leggy A. Arnold, Douglas C. Stafford, James M. Cook
المصدر: Journal of Pharmacological and Toxicological Methods. 82:109-114
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Agonist, medicine.drug_class, GABAA receptor, Allosteric regulation, Long-term potentiation, Biology, Toxicology, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Automated patch clamp, medicine, GABAergic, Patch clamp, Induced pluripotent stem cell, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3855ddab73e494432f8f613ce9564cf4Test
https://doi.org/10.1016/j.vascn.2016.08.006Test -
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المؤلفون: David J. Gavaghan, Ken Wang, Michael Clerx, Chon Lok Lei, Liudmila Polonchuk, Gary R. Mirams
المصدر: Biophysical Journal
مصطلحات موضوعية: Computer science, Voltage clamp, hERG, Biophysics, Gating, CHO Cells, Bayesian inference, 03 medical and health sciences, Automation, 0302 clinical medicine, Cricetulus, Single-cell analysis, Automated patch clamp, Computing & Mathematics - Applied Mathematics, Animals, Humans, Patch clamp, Throughput (business), Ion channel, 030304 developmental biology, Protocol (science), 0303 health sciences, biology, Mathematical model, business.industry, Centre for Mathematical Medicine and Biology, Bayes Theorem, Articles, Potassium channel, Ether-A-Go-Go Potassium Channels, Kinetics, biology.protein, Single-Cell Analysis, business, Biological system, 030217 neurology & neurosurgery, Communication channel
وصف الملف: PDF
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62fd21b3a91ba2c8d4b097be629ae63Test
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المؤلفون: Sylvain Feliciangeli, Vincent Probst, B.B. Ribeiro de Oliveira Mendes, Franck C. Chatelain, B. Ollivier, Jérôme Montnach, F. Kyndt, S. Nicolas, Florian Lesage, Gildas Loussouarn, Isabelle Denjoy, M. De Waard
المصدر: Archives of Cardiovascular Diseases Supplements. 12:257
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, High-throughput screening, Electroporation, hERG, Transfection, Computational biology, Potassium channel, Automated patch clamp, FuGENE, biology.protein, Medicine, cardiovascular diseases, Patch clamp, Cardiology and Cardiovascular Medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::48b64222c03c0b877391f85d739f4066Test
https://doi.org/10.1016/j.acvdsp.2020.03.138Test -
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المؤلفون: Takayuki Oka, Alison Obergrussberger, Søren Friis, Hatsue Furukawa, Nina Brinkwirth, Sonja Stoelzle-Feix, Atsushi Ohtsuki, Yuka Hasegawa, Kiyoshi Takasuna, Niels Fertig, Masafumi Doi, Nadine Becker
المصدر: Journal of Pharmacological and Toxicological Methods. 105:106884
مصطلحات موضوعية: ERG1 Potassium Channel, Patch-Clamp Techniques, hERG, Drug Evaluation, Preclinical, Dofetilide, CHO Cells, 030204 cardiovascular system & hematology, Polypropylenes, Toxicology, 030226 pharmacology & pharmacy, Cell Line, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Automated patch clamp, Drug Discovery, Phenethylamines, medicine, Animals, Humans, Patch clamp, Polytetrafluoroethylene, Ion channel, Pharmacology, Sulfonamides, biology, Chemistry, Drug discovery, Safety pharmacology, Reproducibility of Results, Arrhythmias, Cardiac, Cardiovascular Agents, Heart, Astemizole, Reference Standards, Benchmarking, HEK293 Cells, Calibration, biology.protein, Terfenadine, medicine.drug, Biomedical engineering
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a232b0cdc1e86e3a7f7560e3afb49141Test
https://doi.org/10.1016/j.vascn.2020.106884Test -
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المؤلفون: Fajun Nan, Zhaobing Gao, Jinfeng Yue, Guan-hua Qiao, Ni Liu
المصدر: Acta Pharmacologica Sinica. 37:105-110
مصطلحات موضوعية: 0301 basic medicine, Screening techniques, Patch-Clamp Techniques, High-throughput screening, chemistry.chemical_element, CHO Cells, Fluorescence, 03 medical and health sciences, Cricetulus, Automated patch clamp, High-Throughput Screening Assays, Barracuda, Animals, KCNQ2 Potassium Channel, Pharmacology (medical), Patch clamp, Thallium, Pharmacology, Chromatography, Traditional medicine, biology, General Medicine, biology.organism_classification, 030104 developmental biology, chemistry, Original Article, Ion Channel Gating, Databases, Chemical
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aaba1297759526557a8c8e15b3c9f1Test
https://doi.org/10.1038/aps.2015.142Test -
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المؤلفون: Mika Sugiura, Chizuko Nishizawa-Harada, Tadashi Kimura, Kyoko Kikuchi
المصدر: Biotechnology Reports, Vol 7, Iss C, Pp 17-23 (2015)
Biotechnology Reportsمصطلحات موضوعية: Screen method, lcsh:Biotechnology, Biology, medicine.disease_cause, Applied Microbiology and Biotechnology, Article, Planar patch clamp, Microbiology, Automated patch clamp, lcsh:TP248.13-248.65, medicine, Escherichia coli, Giant spheroplast, Patch clamp, Ion channel, Human Kv2.1, 4-AP (4-aminopyridine), fungi, Spheroplast, TEA (tetraethylammonium), Electrophysiology, Drug screening, Biophysics, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503d1e009dd3ba587d1302ff3ef61e82Test
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المؤلفون: Donglin Guo, Stephen Jenkinson
المصدر: Journal of Pharmacological and Toxicological Methods. 99:106575
مصطلحات موضوعية: Pharmacology, biology, Chemistry, Sodium channel, Wild type, Depolarization, 030204 cardiovascular system & hematology, Nav1.5, Toxicology, 030226 pharmacology & pharmacy, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Minimal effect, Automated patch clamp, Biophysics, biology.protein, Patch clamp, Veratridine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f202c73bdde80cf5c6a719cb45d7ac64Test
https://doi.org/10.1016/j.vascn.2019.04.001Test -
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المؤلفون: Yuji Haraguchi, Tatsuya Shimizu, Takayuki Oka, Atsushi Ohtsuki
المصدر: BMC Pharmacology & Toxicology
مصطلحات موضوعية: ERG1 Potassium Channel, Patch-Clamp Techniques, hERG, CHO Cells, Pharmacology, Membrane Potentials, Cricetulus, Automated patch clamp, Cricetinae, Potassium Channel Blockers, medicine, Animals, Humans, Pharmacology (medical), Channel blocker, Patch clamp, Dose-Response Relationship, Drug, biology, Chinese hamster ovary cell, HEK 293 cells, High-throughput screening, Reproducibility of Results, Potassium channel blocker, hERG channel, Ether-A-Go-Go Potassium Channels, High-Throughput Screening Assays, Electrophysiology, HEK293 Cells, Technical Advance, Drug development, biology.protein, Automated patch-clamp, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d81b52253edccb6f3c2ce00b476b3bTest
https://doi.org/10.1186/s40360-015-0042-9Test