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المؤلفون: Elisa Giovannetti, Laura L. Meijer, Tessa Y S Le Large, Giulia Mantini, Hanneke W. M. van Laarhoven, Nicole C.T. van Grieken, Bart Kok, Connie R. Jimenez, Jaco C. Knol, Geert Kazemier, Thang V. Pham, Niccola Funel, Sander R. Piersma, Maarten F. Bijlsma
المساهمون: Graduate School, CCA - Cancer biology and immunology, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, Center of Experimental and Molecular Medicine, Radiotherapy, Surgery, Medical oncology laboratory, Pathology, Amsterdam Gastroenterology Endocrinology Metabolism
المصدر: JCI Insight
JCI insight, 5(15):e138290. The American Society for Clinical Investigation
JCI Insight, 5(15):e138290
Le Large, T Y S, Mantini, G, Meijer, L L, Pham, T V, Funel, N, van Grieken, N C T, Kok, B, Knol, J, van Laarhoven, H W M, Piersma, S R, Jimenez, C R, Kazemier, G, Giovannetti, E & Bijlsma, M F 2020, ' Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets ', JCI Insight, vol. 5, no. 15, e138290 . https://doi.org/10.1172/jci.insight.138290Testمصطلحات موضوعية: 0301 basic medicine, Proteomics, Male, Stromal cell, Proteome, Molecular biology, Biology, Extracellular matrix, 03 medical and health sciences, Mice, 0302 clinical medicine, Stroma, Pancreatic cancer, medicine, Biomarkers, Tumor, Tumor Cells, Cultured, Animals, Humans, Cancer, Aged, Aged, 80 and over, General Medicine, Cell Biology, Middle Aged, medicine.disease, Prognosis, Xenograft Model Antitumor Assays, Extracellular Matrix, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Survival Rate, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, Female, Stromal Cells, Carcinoma, Pancreatic Ductal, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bd1e4d181261da5e96c3a6fad92ba2Test
https://pubmed.ncbi.nlm.nih.gov/32634123Test -
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المؤلفون: Yves Mentens, Jose Ferri, Godefridus J. Peters, Elisa Giovannetti, Nele Van Der Steen, Paul Germonpré, M. Ramael, Patrick Pauwels, Leticia G. Leon, David R. Gandara, Christian Rolfo
المساهمون: CCA - Cancer biology and immunology, Medical oncology laboratory, Medical oncology, CCA - Cancer Treatment and quality of life, Amsterdam Gastroenterology Endocrinology Metabolism
المصدر: Van Der Steen, N, Mentens, Y, Ramael, M, Leon, L G, Germonpré, P, Ferri, J, Gandara, D R, Giovannetti, E, Peters, G J, Pauwels, P & Rolfo, C 2018, ' Double Trouble : A Case Series on Concomitant Genetic Aberrations in NSCLC ', Clinical Lung Cancer, vol. 19, no. 1, pp. 35-41 . https://doi.org/10.1016/j.cllc.2017.06.010Test
Clinical Lung Cancer, 19(1), 35-41. Elsevier
Clinical lung cancerمصطلحات موضوعية: 0301 basic medicine, Pulmonary and Respiratory Medicine, Cancer Research, Lung Neoplasms, medicine.medical_treatment, Viral Oncogene, medicine.disease_cause, Targeted therapy, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Exon, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Anaplastic lymphoma kinase, Anaplastic Lymphoma Kinase, Genetic Testing, Molecular Targeted Therapy, Epidermal growth factor receptor, Neoplasm Metastasis, Lung cancer, Genetic testing, biology, medicine.diagnostic_test, business.industry, Middle Aged, Proto-Oncogene Proteins c-met, medicine.disease, ErbB Receptors, 030104 developmental biology, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Female, Human medicine, KRAS, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184d2225d523195834ff5aba158882edTest
https://doi.org/10.1016/j.cllc.2017.06.010Test -
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المؤلفون: Michal Stark, Elisa Giovannetti, Gerrit Jansen, Larry H. Matherly, Maria Gemelli, Godefridus J. Peters, Erik Thunnissen, Ittai B. Muller, Zhanjun Hou, P. A. Zucali, E. A. Struys, Niccola Funel, M. Perrino, Yehuda G. Assaraf
المساهمون: Medical oncology laboratory, CCA - Cancer biology and immunology, Pathology, Clinical chemistry, AGEM - Inborn errors of metabolism, AGEM - Endocrinology, metabolism and nutrition, Rheumatology, AGEM - Digestive immunity
المصدر: Annals of Oncology, 28(11), 2725-2732. Oxford University Press
Giovannetti, E, Zucali, P A, Assaraf, Y G, Funel, N, Gemelli, M, Stark, M, Thunnissen, E, Hou, Z, Muller, I B, Struys, E A, Perrino, M, Jansen, G, Matherly, L H & Peters, G J 2017, ' Role of proton-coupled folate transporter in pemetrexed resistance of mesothelioma : Clinical evidence and new pharmacological tools ', Annals of Oncology, vol. 28, no. 11, pp. 2725-2732 . https://doi.org/10.1093/annonc/mdx499Testمصطلحات موضوعية: Male, Mesothelioma, 0301 basic medicine, Oncology, Thymidylate synthase, Immunoenzyme Techniques, Reduced Folate Carrier Protein, chemistry.chemical_compound, 0302 clinical medicine, Tumor Cells, Cultured, Aged, 80 and over, biology, Hematology, Methylation, Middle Aged, Prognosis, Survival Rate, Pemetrexed, 030220 oncology & carcinogenesis, Antifolate, Immunohistochemistry, Female, Proton-Coupled Folate Transporter, medicine.drug, Adult, medicine.medical_specialty, Pleural Neoplasms, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, medicine, Humans, Gene silencing, Survival rate, Aged, Cell Proliferation, business.industry, Original Articles, Thymidylate Synthase, medicine.disease, 030104 developmental biology, chemistry, Drug Resistance, Neoplasm, biology.protein, Folic Acid Antagonists, business, Follow-Up Studies
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccf6187f967e64fb83a9f2dcd466830Test
https://doi.org/10.1093/annonc/mdx499Test -
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المؤلفون: Henk L. Dekker, Elisa Giovannetti, Marcello Tiseo, Patrick Pauwels, Filip Lardon, Christian Rolfo, Kaylee Keller, Rob Ruijtenbeek, Alessandro Leonetti, Niccola Funel, Godefridus J. Peters, Nele Van Der Steen
المساهمون: Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer biology and immunology
المصدر: Biochemical pharmacology
van der Steen, N, Leonetti, A, Keller, K, Dekker, H, Funel, N, Lardon, F, Ruijtenbeek, R, Tiseo, M, Rolfo, C, Pauwels, P, Peters, G J & Giovannetti, E 2019, ' Decrease in phospho-PRAS40 plays a role in the synergy between erlotinib and crizotinib in an EGFR and cMET wild-type squamous non-small cell lung cancer cell line ', Biochemical Pharmacology, vol. 166, pp. 128-138 . https://doi.org/10.1016/j.bcp.2019.05.014Test
Biochemical Pharmacology, 166, 128-138. Elsevier Inc.مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, Lung Neoplasms, Antineoplastic Agents, Biochemistry, 03 medical and health sciences, Erlotinib Hydrochloride, 0302 clinical medicine, Crizotinib, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Epidermal growth factor receptor, Phosphorylation, Lung cancer, Protein kinase B, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, Aged, Pharmacology, biology, Chemistry, Pharmacology. Therapy, Drug Synergism, Cell cycle, Middle Aged, Proto-Oncogene Proteins c-met, medicine.disease, ErbB Receptors, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Female, Erlotinib, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198c1da7976161631dcc7ca088486798Test
https://hdl.handle.net/10067/1611930151162165141Test -
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المؤلفون: Marcello Tiseo, Godefridus J. Peters, Paul Germonpré, Christian Rolfo, Nele Van Der Steen, Christophe Hermans, Giulia Mazzaschi, Elisa Giovannetti, Karen Zwaenepoel, Daan P. Geerke, Patrick Pauwels, Paul Van Schil, Ken Op de Beeck, Filip Lardon, Rosa A. Luirink
المساهمون: Medical oncology laboratory, AGEM - Re-generation and cancer of the digestive system, CCA - Imaging and biomarkers, AIMMS, Molecular and Computational Toxicology
المصدر: Molecules
Volume 24
Issue 24
Molecules: a journal of synthetic chemistry and natural product chemistry
Molecules, 24(24). Multidisciplinary Digital Publishing Institute
van der Steen, N, Zwaenepoel, K, Mazzaschi, G, A Luirink, R, P Geerke, D, op de Beeck, K, Hermans, C, Tiseo, M, van Schil, P, Lardon, F, Germonpré, P, Rolfo, C, Giovannetti, E, J Peters, G & Pauwels, P 2019, ' The Role of c-Met as a Biomarker and Player in Innate and Acquired Resistance in Non-Small-Cell Lung Cancer: Two New Mutations Warrant Further Studies ', Molecules, vol. 24, no. 24 . https://doi.org/10.3390/molecules24244443Test
Molecules, 24(24):4443. Multidisciplinary Digital Publishing Institute (MDPI)
Van Der Steen, N, Zwaenepoel, K, Mazzaschi, G, Luirink, R A, Geerke, D P, De Beeck, K O, Hermans, C, Tiseo, M, Van Schil, P, Lardon, F, Germonpré, P, Rolfo, C, Giovannetti, E, Peters, G J & Pauwels, P 2019, ' The role of c-met as a biomarker and player in innate and acquired resistance in non-small-cell lung cancer : Two new mutations warrant further studies ', Molecules, vol. 24, no. 24, 4443 . https://doi.org/10.3390/molecules24244443Testمصطلحات موضوعية: Male, Lung Neoplasms, Mutant, Pharmaceutical Science, NSCLC, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, Drug Discovery, Epidermal growth factor receptor, Neoplasm Metastasis, Receptor, 0303 health sciences, biology, Middle Aged, Proto-Oncogene Proteins c-met, 3. Good health, ErbB Receptors, Gene Expression Regulation, Neoplastic, Chemistry, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, Biomarker (medicine), Female, Antibody, Adult, C-Met, EGFR, Article, Deep sequencing, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Biomarkers, Tumor, medicine, Humans, Physical and Theoretical Chemistry, Lung cancer, Biology, Aged, 030304 developmental biology, business.industry, Organic Chemistry, Gene Amplification, medicine.disease, chemistry, Drug Resistance, Neoplasm, Mutation, biology.protein, Cancer research, Tumor Suppressor Protein p53, business, Biomarkers
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41c017861e5a2eba24b3519c13c0ba8Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85076355617&origin=inwardTest -
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المساهمون: Surgery, Medical oncology laboratory, CCA - Target Discovery & Preclinial Therapy Development
المصدر: Meijer, L L, Puik, J R, Peters, G J, Kazemier, G & Giovannetti, E 2016, ' hENT-1 Expression and Localization Predict Outcome After Adjuvant Gemcitabine in Resected Cholangiocarcinoma Patients ', The Oncologist, vol. 21, no. 12, pp. e4 . https://doi.org/10.1634/theoncologist.2016-0262Test
The Oncologist
The Oncologist, 21(12). AlphaMed Pressمصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, Antimetabolites, Antineoplastic, medicine.medical_treatment, Treatment outcome, Equilibrative nucleoside transporter 1, Deoxycytidine, Disease-Free Survival, Cholangiocarcinoma, Equilibrative Nucleoside Transporter 1, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Letters to the Editor, Aged, Chemotherapy, biology, business.industry, Middle Aged, Gemcitabine, 030104 developmental biology, Bile Duct Neoplasms, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, biology.protein, Biomarker (medicine), Female, business, Adjuvant, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2356f1bce196ea80a75555ea4263dae6Test
https://doi.org/10.1634/theoncologist.2016-0262Test -
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المؤلفون: Jacobus A. Burgers, Godefridus J. Peters, Egbert F. Smit, Elisa Giovannetti, Francesco Di Costanzo, Andrea Ardizzoni, Carmelo Tibaldi, Andrea Camerini, Fausto Barbieri, Marcello Tiseo, Andrew D. Vincent
المساهمون: Medical oncology laboratory, Pulmonary medicine, CCA - Innovative therapy, Tiseo, Marcello, Giovannetti, Elisa, Tibaldi, Carmelo, Camerini, Andrea, Di Costanzo, Francesco, Barbieri, Fausto, Burgers, Jacobus A., Vincent, Andrew, Peters, Godefridus J., Smit, Egbert F., Ardizzoni, Andrea
المصدر: Lung Cancer, 78(1), 92-99. Elsevier Ireland Ltd
Tiseo, M, Giovannetti, E, Tibaldi, C, Camerini, A, Di Costanzo, F, Barbieri, F, Burgers, J A, Vincent, A D, Peters, G J, Smit, E F & Ardizzoni, A 2012, ' Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin ', Lung Cancer, vol. 78, no. 1, pp. 92-99 . https://doi.org/10.1016/j.lungcan.2012.07.009Testمصطلحات موضوعية: Male, Oncology, Cancer Research, Lung Neoplasms, non-small cell lung cancer (NSCLC), Pharmacology, Thymidylate synthase, Carboplatin, Antineoplastic Agent, Reduced Folate Carrier Protein, chemistry.chemical_compound, Gene Frequency, Glutamates, Retrospective Studie, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Allele, Aged, 80 and over, biology, Pharmacogenetic, Hazard ratio, Middle Aged, Treatment Outcome, Pemetrexed, Female, Glutamate, Human, medicine.drug, Adult, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Guanine, Genotype, Non-small cell lung cancer (NSCLC), Antineoplastic Agents, Polymorphism, Single Nucleotide, Internal medicine, medicine, Humans, Alleles, Methylenetetrahydrofolate Reductase (NADPH2), Aged, Neoplasm Staging, Retrospective Studies, Xeroderma Pigmentosum Group D Protein, Antineoplastic Combined Chemotherapy Protocol, business.industry, Proportional hazards model, Thymidylate Synthase, gamma-Glutamyl Hydrolase, MTHFR-C667T polymorphism, medicine.disease, Lung Neoplasm, chemistry, Methylenetetrahydrofolate reductase, biology.protein, business, Pharmacogenetics
وصف الملف: ELETTRONICO
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75b870f6ebcd4b15db069e24f07cf1Test
https://doi.org/10.1016/j.lungcan.2012.07.009Test -
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المؤلفون: Yisong Wang, Elisa Giovannetti, Niccola Funel, Jih-Hsiang Lee, Paul S. Meltzer, Jin-Hyeok Hwang, Qiuyan Wang, Seth M. Steinberg, Yonghong Wang, Johannes Voortman, Giuseppe Giaccone, Iacopo Petrini
المساهمون: Medical oncology laboratory, Medical oncology, CCA - Disease profiling
المصدر: Lee, J, Giovannetti, E, Hwang, J H, Petrini, I, Wang, Q Y, Voortman, J, Wang, Y H, Steinberg, S M, Funel, N, Meltzer, P S, Wang, Y S & Giaccone, G 2012, ' Loss of 18q22.3 Involving the Carboxypeptidase of Glutamate-like Gene Is Associated with Poor Prognosis in Resected Pancreatic Cancer ', Clinical Cancer Research, vol. 18, no. 2, pp. 524-533 . https://doi.org/10.1158/1078-0432.CCR-11-1903Test
Clinical Cancer Research, 18(2), 524-533. American Association for Cancer Research Inc.مصطلحات موضوعية: Male, Dipeptidases, Cancer Research, Pathology, Aged, Aged, 80 and over, Carcinoma, Pancreatic Ductal, Cell Line, Tumor, Chromosomes, Human, Pair 18, Cohort Studies, Comparative Genomic Hybridization, DNA Copy Number Variations, DNA Mutational Analysis, Disease-Free Survival, Female, Genes, Tumor Suppressor, Humans, Kaplan-Meier Estimate, Middle Aged, Pancreatic Neoplasms, Prognosis, Proportional Hazards Models, Proto-Oncogene Proteins, Tumor Suppressor Protein p53, ras Proteins, Chromosome Deletion, Oncology, medicine.disease_cause, 80 and over, Copy-number variation, Tumor, Cell cycle, Pancreatic Ductal, KRAS, Tumor Suppressor, Human, medicine.medical_specialty, Biology, Chromosomes, Article, Cell Line, Proto-Oncogene Proteins p21(ras), Pancreatic cancer, medicine, Gene, Pair 18, Cell growth, Carcinoma, Cancer, medicine.disease, Genes, Cancer research, Comparative genomic hybridization
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b502364e7b1272bcea01d050c9212929Test
https://doi.org/10.1158/1078-0432.ccr-11-1903Test -
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المؤلفون: Ines J. Beumer, Elisa Giovannetti, Kees Smid, Robert Mauritz, Cees J. van Groeningen, Herbert M. Pinedo, Godefridus J. Peters
المساهمون: Medical oncology, Internal medicine, Medical oncology laboratory, CCA - Innovative therapy
المصدر: Mauritz, R, Giovannetti, E, Beumer, I J, Smid, K, van Groeningen, C J, Pinedo, H M & Peters, G J 2009, ' Polymorphisms in the Enhancer Region of the Thymidylate Synthase Gene Are Associated with Thymidylate Synthase Levels in Normal Tissues but Not in Malignant Tissues of Patients with Colorectal Cancer ', Clinical Colorectal Cancer, vol. 8, no. 3, pp. 146-154 . https://doi.org/10.3816/CCC.2009.n.024Test
Clinical Colorectal Cancer, 8(3), 146-154. Elsevierمصطلحات موضوعية: Adult, Male, Colorectal cancer, Colon, Thymidylate synthase, Metastasis, Genotype, medicine, Humans, RNA, Messenger, RNA, Neoplasm, Allele, Gene, Aged, Aged, 80 and over, Polymorphism, Genetic, biology, Reverse Transcriptase Polymerase Chain Reaction, Liver Neoplasms, Gastroenterology, Rectum, Thymidylate Synthase, Middle Aged, medicine.disease, Prognosis, Primary tumor, Molecular biology, Phenotype, Enhancer Elements, Genetic, Treatment Outcome, Oncology, biology.protein, Cancer research, Female, Neoplasm Recurrence, Local, Colorectal Neoplasms
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::053976b58f3f2f3db5c3796910b595f6Test
https://doi.org/10.3816/ccc.2009.n.024Test -
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المؤلفون: Leticia G. Leon, Niccola Funel, Ugo Boggi, Luca Pollina, Elisa Giovannetti, Amir Avan, Nelide De Lio, Enrico Vasile, Daniela Campani, Valentina Galla, S. Caponi, Hiroko Sudo, Vittorio Perrone, Arjan van der Velde, Godefridus J. Peters, Alfredo Falcone
المساهمون: Medical oncology laboratory, CCA - Innovative therapy
المصدر: PLoS ONE, Vol 7, Iss 11, p e49145 (2012)
Università di Pisa-IRIS
PLoS ONE, 7(11), e49145-e49145. Public Library of Science
PLoS ONE
Giovannetti, E, te Velde, A, Funel, N, Vasile, E, Perrone, V, Leon, L G, De Lio, N, Avan, A, Caponi, S, Pollina, L E, Galla, V, Sudo, H, Falcone, A, Campani, D, Boggi, U & Peters, G J 2012, ' High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer ', PLoS ONE, vol. 7, no. 11, pp. e49145-e49145 . https://doi.org/10.1371/journal.pone.0049145Testمصطلحات موضوعية: Male, Oncology, Cancer Treatment, Bioinformatics, Pathology, Multidisciplinary, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Medicine, Female, Oncology Agents, DNA microarray, Carcinoma, Pancreatic Ductal, Research Article, Adult, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Science, Pancreatic Cancer, Diagnostic Medicine, Internal medicine, Pancreatic cancer, Gastrointestinal Tumors, microRNA, Biomarkers, Tumor, Genetics, Cancer Genetics, Overall survival, medicine, Carcinoma, Humans, Diagnostic biomarker, Biology, Aged, Retrospective Studies, business.industry, Gene Expression Profiling, Cancers and Neoplasms, Chemotherapy and Drug Treatment, medicine.disease, Pancreatic Neoplasms, Gene expression profiling, MicroRNAs, business, Biomarkers, General Pathology
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c192e74783383401f081e13ca0aa88dTest
http://hdl.handle.net/11568/209018Test
