-
1
المؤلفون: Suqing Zheng, René V. Bensasson, Albena T. Dinkova-Kostova, Wei Li, Akira Saito, Vincent Zoete, Tadashi Honda
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:4345-4349
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Electrons, Alkenes, 01 natural sciences, Biochemistry, Mice, 03 medical and health sciences, Cell Line, Tumor, Nitriles, Drug Discovery, NAD(P)H Dehydrogenase (Quinone), Animals, Potency, Reactivity (chemistry), Sulfhydryl Compounds, Enzyme inducer, Molecular Biology, HOMO/LUMO, chemistry.chemical_classification, Kelch-Like ECH-Associated Protein 1, Molecular Structure, biology, Bicyclic molecule, 010405 organic chemistry, Chemistry, Organic Chemistry, Ketones, 0104 chemical sciences, 030104 developmental biology, Enzyme, Electron affinity (data page), Cyclization, Cytoprotection, Enzyme Induction, biology.protein, Quantum Theory, Molecular Medicine, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b72f814fedbc5f4e00f65a00584375eTest
https://doi.org/10.1016/j.bmcl.2016.07.028Test -
2
المؤلفون: Albena T. Dinkova-Kostova, Noemí Esteras, Andrey Y. Abramov
المصدر: Biological Chemistry. 397:383-400
مصطلحات موضوعية: 0301 basic medicine, NF-E2-Related Factor 2, Clinical Biochemistry, Biology, Mitochondrion, medicine.disease_cause, Biochemistry, Glycogen Synthase Kinase 3, 03 medical and health sciences, GSK-3, medicine, Animals, Humans, Amyotrophic lateral sclerosis, Molecular Biology, Transcription factor, Neurodegeneration, Brain, Membrane Transport Proteins, Neurodegenerative Diseases, Lipid Metabolism, medicine.disease, KEAP1, Mitochondria, Cell biology, 030104 developmental biology, DNAJA3, Energy Metabolism, Oxidative stress
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b203cc5d84e06233220baa32b16a02Test
https://doi.org/10.1515/hsz-2015-0295Test -
3
المصدر: Antioxidants & Redox Signaling. 13:1713-1748
مصطلحات موضوعية: NF-E2-Related Factor 2, Physiology, Clinical Biochemistry, Vesicular Transport Proteins, Biology, Response Elements, medicine.disease_cause, environment and public health, Biochemistry, Antioxidants, Ubiquitin, Neoplasms, Maf Transcription Factors, medicine, Anticarcinogenic Agents, Humans, Molecular Biology, Gene, Transcription factor, Adaptor Proteins, Signal Transducing, Cell Proliferation, General Environmental Science, Kelch-Like ECH-Associated Protein 1, Intracellular Signaling Peptides and Proteins, Signal transducing adaptor protein, Cell Biology, Cullin Proteins, KEAP1, Regulatory sequence, Trans-Activators, biology.protein, General Earth and Planetary Sciences, Carrier Proteins, Carcinogenesis, Signal Transduction, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3105d8745b9c25143471f4cfab538b09Test
https://doi.org/10.1089/ars.2010.3221Test -
4
المؤلفون: Albena T. Dinkova-Kostova, Mark P. Mattson, Vittorio Calabrese, Carolin Cornelius, Edward J. Calabrese
المصدر: Antioxidants & Redox Signaling. 13:1763-1811
مصطلحات موضوعية: NF-E2-Related Factor 2, Physiology, Chronic oxidative stress, Clinical Biochemistry, Population, Pharmacology, Biology, Nitric Oxide, medicine.disease_cause, Biochemistry, Neuroprotection, Therapeutic index, Comprehensive Invited Review, Intervention (counseling), medicine, Animals, Homeostasis, Humans, Sirtuins, education, Molecular Biology, General Environmental Science, Carbon Monoxide, education.field_of_study, Kelch-Like ECH-Associated Protein 1, Dose-Response Relationship, Drug, Cell Membrane, Neurodegeneration, Intracellular Signaling Peptides and Proteins, Hormesis, Neurodegenerative Diseases, Cell Biology, medicine.disease, Mitochondria, Oxidative Stress, Neuroprotective Agents, Heme Oxygenase (Decyclizing), Nerve Degeneration, General Earth and Planetary Sciences, Lipid Peroxidation, Oxidation-Reduction, Neuroscience, Oxidative stress, Molecular Chaperones, Phytotherapy
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3336e3f69164b656ac54e7885e8da4Test
https://doi.org/10.1089/ars.2009.3074Test -
5
المؤلفون: D. Allan Butterfield, Albena T. Dinkova-Kostova, Vittorio Calabrese, Carolin Cornelius, Joshua B. Owen, Enrico Rizzarelli
المصدر: Antioxidants & redox signalling 11 (2009): 2717–2739. doi:10.1089/ars.2009.2721
info:cnr-pdr/source/autori:Rizzarelli, Enrico (1); Calabrese, Vittorio (1); Butterfield, D. Allan (2); Owen, Joshua B. (2); Cornelius, Carolin (1); Dinkova-Kostova, Albena T. (4)/titolo:Nitric oxide in cell survival: a Janus molecule/doi:10.1089%2Fars.2009.2721/rivista:Antioxidants & redox signalling/anno:2009/pagina_da:2717/pagina_a:2739/intervallo_pagine:2717–2739/volume:11مصطلحات موضوعية: Central Nervous System, Nervous system, Cell Survival, Physiology, Clinical Biochemistry, Biology, Nitric Oxide, Models, Biological, Biochemistry, Nitric oxide, chemistry.chemical_compound, medicine, Animals, Humans, Molecular Biology, Transcription factor, Reactive nitrogen species, Neuroinflammation, General Environmental Science, PROTEIN S-NITROSYLATION, LONG-TERM POTENTIATION, ANTIOXIDANT RESPONSE ELEMENT, ALZHEIMERS-DISEASE BRAIN, CENTRAL-NERVOUS-SYSTEM, Neurodegeneration, Long-term potentiation, Cell Biology, medicine.disease, Reactive Nitrogen Species, Cell biology, medicine.anatomical_structure, chemistry, General Earth and Planetary Sciences, Peroxynitrite, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c694bf88ab3fd9c1af6bd229cbdb5c3Test
https://doi.org/10.1089/ars.2009.2721Test -
6
المصدر: BioFactors (Oxford, England). 35(2)
مصطلحات موضوعية: and the sirtuin protein systems. Dietary antioxidants, Clinical Biochemistry, Cellular homeostasis, such as polyphenols and L-carnitine/acetyl-L-carnitine, Biochemistry, Hsp70, Stress Response Signaling, and transcriptional processes. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, Modulation of endogenous cellular defense mechanisms via the stress response signaling represents ad innovative approach to therapeutic intervention in diseases causing chronic damage, Stress, Physiological, Heat shock protein, Cellular stress response, challenges long-standing beliefs about the nature of the dose-response in a low dose zone, Animals, Homeostasis, Humans, Heat shock, biology, General Medicine, such as neurodegeneration and cancer. Protein thiols play a key role in redox sensing, including vitagenes. The hormetic dose-response, Cell biology, Heat shock factor, and regulation of cellular redox state is crucial mediator of multiple metabolic, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, having the potential to affect significantly the design of. pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. Given the broad cytoprotective properties of the heat shock response, the thioredoxin, Modulation of endogenous cellular defense mechanisms via the stress response signaling represents ad innovative approach to therapeutic intervention in diseases causing chronic damage, such as neurodegeneration and cancer. Protein thiols play a key role in redox sensing, and regulation of cellular redox state is crucial mediator of multiple metabolic, signaling, and transcriptional processes. Maintenance of optimal long-term health conditions is accomplished by a complex network of longevity assurance processes that are controlled by vitagenes, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Hsp70, the thioredoxin, and the sirtuin protein systems. Dietary antioxidants, such as polyphenols and L-carnitine/acetyl-L-carnitine, have recently been demonstrated to be neuroprotective through the activation of hormetic pathways, including vitagenes. The hormetic dose-response, challenges long-standing beliefs about the nature of the dose-response in a low dose zone, having the potential to affect significantly the design of. pre-clinical studies and clinical trials as well as strategies for optimal patient dosing in the treatment of numerous diseases. Given the broad cytoprotective properties of the heat shock response, there is now strong interest in discovering and developing pharmacological agents capable of inducing these responses. In this review we discuss the most current and up-to-date understanding of the possible signaling mechanisms by which acetylcarnitine by activating vitagenes can differentially modulate signal transduction cascades inducing apoptosis/cell death in abnormal cancer cells but at the same time enhancing defensive enzymes to protect against carcinogenesis and neurodegeneration in normal cells, Cytoprotection, Sirtuin, biology.protein, a group of genes involved in preserving cellular homeostasis during stressful conditions. Vitagenes encode for heat shock proteins (Hsp) Hsp32, Molecular Medicine, Thioredoxin, there is now strong interest in discovering and developing pharmacological agents capable of inducing these responses. In this review we discuss the most current and up-to-date understanding of the possible signaling mechanisms by which acetylcarnitine by activating vitagenes can differentially modulate signal transduction cascades inducing apoptosis/cell death in abnormal cancer cells but at the same time enhancing defensive enzymes to protect against carcinogenesis and neurodegeneration in normal cells, signaling, Acetylcarnitine, Energy Metabolism, Molecular Chaperones
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf1db97388cee7d07d428c80a3d0beb3Test
https://pubmed.ncbi.nlm.nih.gov/19449442Test -
7
المؤلفون: Michael A. Costa, Laurence B. Davin, Huai Bin Wang, Masayuki Fujita, Albena T. Dinkova-Kostova, Vincent Burlat, Simo Sarkanen, David R. Gang, William Martin, Norman G. Lewis
المصدر: Chemistrybiology. 6(3)
مصطلحات موضوعية: DNA, Plant, Free Radicals, Clinical Biochemistry, Blotting, Western, Molecular Sequence Data, Biology, Biochemistry, Lignin, Polymerase Chain Reaction, Lignans, chemistry.chemical_compound, Epitopes, radical coupling, Drug Discovery, Amino Acid Sequence, dirigent protein, Molecular Biology, Peptide sequence, lignins, Plant Proteins, Pharmacology, chemistry.chemical_classification, Lignan, Genome, fungi, General Medicine, Plants, Recombinant Proteins, Amino acid, Blotting, Southern, Dirigent protein, chemistry, biology.protein, Molecular Medicine, Stereoselectivity, Monolignol, Function (biology), Subcellular Fractions
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe5dc60660a5ba899fde0ebfd2994e7Test
https://pubmed.ncbi.nlm.nih.gov/10074466Test -
8
المؤلفون: Philip A. Cole, Ying Zhang, Vittorio Calabrese, Ronald J. Hicks, Young Hoon Ahn, Ivor J. Benjamin, Albena T. Dinkova-Kostova, Tadashi Honda
المصدر: Chemistry & Biology. (11):1355-1361
مصطلحات موضوعية: NF-E2-Related Factor 2, Clinical Biochemistry, Biology, Biochemistry, digestive system, environment and public health, Article, Cell Line, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Heat Shock Transcription Factors, Heat shock protein, Drug Discovery, Animals, Humans, HSP70 Heat-Shock Proteins, Sulfhydryl Compounds, Heat shock, HSF1, Transcription factor, Molecular Biology, 030304 developmental biology, Pharmacology, 0303 health sciences, Kelch-Like ECH-Associated Protein 1, fungi, Intracellular Signaling Peptides and Proteins, General Medicine, respiratory system, KEAP1, Triterpenes, Hsp70, Cell biology, Up-Regulation, Heat shock factor, DNA-Binding Proteins, Molecular Medicine, Pentacyclic Triterpenes, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffedb8a0a3f46aa31dc08b85405b40ceTest