Abstract LB225: Colon cancer preventive efficacy of licofelone and its analogue LFA-9 in PIRC rat model of FAP
| العنوان: | Abstract LB225: Colon cancer preventive efficacy of licofelone and its analogue LFA-9 in PIRC rat model of FAP |
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| المؤلفون: | Anh Bao, Altaf Mohammed, David L. McCormick, Nagendra S. Yarla, Venkateshwar Madka, Yuting Zhang, Shizuko Sei, Nicole Stratton, Gopal Pathuri, Chinthalapally V. Rao, Jennifer T. Fox, Anil Singh |
| المصدر: | Cancer Research. 81:LB225-LB225 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, biology, Colorectal cancer, business.industry, Prostaglandin, Cancer, Inflammation, Pharmacology, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, Antithrombotic, Toxicity, medicine, biology.protein, Cyclooxygenase, medicine.symptom, business, Licofelone |
| الوصف: | Inflammation is a key hallmark of many cancers and potent target for chemoprevention. Experimental and clinical intervention studies indicate strong cancer preventive efficacy of cyclooxygenase (COX)-2 inhibitors. Their use for chemoprevention is limited due to increased cardiovascular (CV) toxicities. Selective COX-2 inhibition diverts arachidonic acid to the 5-lipoxygenase (5-LOX) pathway resulting in accumulation of prothrombotic leukotrienes while depleting antithrombotic prostaglandin (PG)I2, leading to increased risk of CV events. To overcome side effects, balanced dual inhibitors targeting COX-2/5-LOX or microsomal PGE synthase (mPGES)-1/5-LOX enzymes are being developed for chemoprevention. In this study, the clinically advanced dual COX-2/5-LOX inhibitor, licofelone, and its glycine analogue (LFA-9), the mPGES-1/5-LOX dual inhibitor, were evaluated for colon cancer preventive efficacy in the FAP relevant PIRC rat model. In preclinical dose range finding and preliminary toxicity studies in F344 rats, dietary administration of licofelone Citation Format: Venkateshwar Madka, Nagendra S. Yarla, Gopal Pathuri, Yuting Zhang, Anh Bao, Nicole C. Stratton, Anil Singh, David L. McCormick, Altaf Mohammed, Shizuko Sei, Jennifer Fox, Chinthalapally V. Rao. Colon cancer preventive efficacy of licofelone and its analogue LFA-9 in PIRC rat model of FAP [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr LB225. |
| تدمد: | 1538-7445 0008-5472 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::16690316b3bb3785301e362f8d835e01Test https://doi.org/10.1158/1538-7445.am2021-lb225Test |
| رقم الانضمام: | edsair.doi...........16690316b3bb3785301e362f8d835e01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387445 00085472 |
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