المؤلفون: Xin Yan Pei, Yun Dai, Shuang Chen, Robert Z. Orlowski, Liang Zhou, Yun Leng, Richard J. Jones, Steven Grant, Maciej Kmieciak, Yu Zhang, Hui Lin

المصدر: Blood. 124:2687-2697

مصطلحات موضوعية: cells, Fluorescent Antibody Technique, Apoptosis, Mice, SCID, Hydroxamic Acids, Biochemistry, Bortezomib, Small hairpin RNA, immune system diseases, Mice, Inbred NOD, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Cells, Cultured, Mice, Knockout, Gene knockdown, Lymphoid Neoplasia, Bcl-2-Like Protein 11, hemic and immune systems, Hematology, Boronic Acids, Tumor Burden, Pyrazines, RNA Interference, biological phenomena, cell phenomena, and immunity, Multiple Myeloma, medicine.drug, Immunoblotting, Immunology, Biology, Downregulation and upregulation, Cell Line, Tumor, Proto-Oncogene Proteins, Autophagy, medicine, Animals, Humans, neoplasms, Membrane Proteins, Cell Biology, Xenograft Model Antitumor Assays, Molecular biology, Histone Deacetylase Inhibitors, Drug Resistance, Neoplasm, Cell culture, Cancer research, Histone deacetylase, Apoptosis Regulatory Proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb906a6b85294c357a4a699ef6fac4eTest
https://doi.org/10.1182/blood-2014-03-564534Test

المؤلفون: Donna M. Weber, Caimiao Wei, R. Eric Davis, Deborah J. Kuhn, Zuzana Berkova, Timothy Madden, Sheeba K. Thomas, Veerabhadran Baladandayuthapani, Robert Z. Orlowski, Richard Woessner, Michael Wang, Hua Wang, Chad C. Bjorklund, Richard J. Jones, Jatin J. Shah, Wencai Ma, Pei Lin

المصدر: Blood. 120:3260-3270

مصطلحات موضوعية: medicine.medical_treatment, Blotting, Western, Immunology, Antineoplastic Agents, Apoptosis, Enzyme-Linked Immunosorbent Assay, Mice, SCID, Pharmacology, Biochemistry, Receptor, IGF Type 1, Bortezomib, Mice, Paracrine signalling, Insulin-like growth factor, immune system diseases, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Animals, Humans, Insulin-Like Growth Factor I, Autocrine signalling, Receptor, Multiple myeloma, Cell Proliferation, Oligonucleotide Array Sequence Analysis, Lymphoid Neoplasia, biology, Cell growth, Gene Expression Profiling, Imidazoles, Drug Synergism, Cell Biology, Hematology, Flow Cytometry, medicine.disease, Boronic Acids, Xenograft Model Antitumor Assays, Survival Rate, Insulin receptor, Drug Resistance, Neoplasm, Pyrazines, biology.protein, Multiple Myeloma, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb1ec3310b35c2bd7d5caecbbfd8b34Test
https://doi.org/10.1182/blood-2011-10-386789Test

المؤلفون: Deborah J. Kuhn, Jeffrey A. Nemeth, Peter M. Voorhees, Mohamed H. Zaki, Robert Corringham, Sally A. Hunsucker, George W. Small, John S. Strader, Qing Chen, Robert Z. Orlowski

المصدر: Clinical Cancer Research. 13:6469-6478

مصطلحات موضوعية: STAT3 Transcription Factor, Cancer Research, Stromal cell, Myeloid, Cell, Antineoplastic Agents, Apoptosis, Bone Marrow Cells, DNA Fragmentation, Biology, Bortezomib, immune system diseases, hemic and lymphatic diseases, medicine, Humans, HSP70 Heat-Shock Proteins, Multiple myeloma, Interleukin-6, Antibodies, Monoclonal, medicine.disease, Boronic Acids, Gene Expression Regulation, Neoplastic, STAT1 Transcription Factor, medicine.anatomical_structure, Oncology, Proteasome, Drug Resistance, Neoplasm, Pyrazines, Proteasome inhibitor, Cancer research, Immunotherapy, Syndecan-1, Bone marrow, Multiple Myeloma, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d80fcc7d270795afdc7ae89e3e0f8fTest
https://doi.org/10.1158/1078-0432.ccr-07-1293Test

المؤلفون: Robert Z. Orlowski, Peter M. Voorhees

المصدر: Annual Review of Pharmacology and Toxicology. 46:189-213

مصطلحات موضوعية: Proteasome Endopeptidase Complex, medicine.medical_treatment, Antineoplastic Agents, Toxicology, Bortezomib, Ubiquitin, Neoplasms, hemic and lymphatic diseases, Heat shock protein, medicine, Animals, Humans, Multiple myeloma, Pharmacology, Chemotherapy, biology, Cancer, medicine.disease, Boronic Acids, Cell Transformation, Neoplastic, Proteasome, Drug Resistance, Neoplasm, Pyrazines, Cancer research, Proteasome inhibitor, biology.protein, Proteasome Inhibitors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f887002dcb90f3b28292980505a10e0Test
https://doi.org/10.1146/annurev.pharmtox.46.120604.141300Test

المؤلفون: Paul G. Richardson, Alessandra Di Bacco, Andrew Dorner, Allison Berger, Deborah Ricci, Pieter Sonneveld, Erik Koenig, Robert Z. Orlowski, Jeśus F.San Miguel, Hugues Bernard, Edward A. Stadtmauer, William L. Trepicchio, David I. Lichter, Helgi van de Velde, Sundar Jagannath, Matthew Schu, Kenneth C. Anderson, Stephen J. Blakemore, Nibedita Chattopadhyay, Dixie Lee Esseltine, George Mulligan, Joseph B. Bolen, Rachel Neuwirth, Bin Li, Sagar Lonial, James R. Berenson

المساهمون: Radiology & Nuclear Medicine, Epidemiology, Hematology

المصدر: Blood, 123(5), 632-639. American Society of Hematology

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Clinical Trials and Observations, Immunology, Antineoplastic Agents, PDGFRA, Biology, Bioinformatics, medicine.disease_cause, Biochemistry, GTP Phosphohydrolases, Bortezomib, Cohort Studies, Proto-Oncogene Proteins p21(ras), immune system diseases, hemic and lymphatic diseases, Proto-Oncogene Proteins, medicine, Humans, neoplasms, Survival analysis, Multiple myeloma, Dexamethasone, Mutation, Dose-Response Relationship, Drug, Membrane Proteins, Cell Biology, Hematology, medicine.disease, Prognosis, Boronic Acids, Survival Analysis, digestive system diseases, Pyrazines, Cancer research, ras Proteins, KRAS, Multiple Myeloma, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc7a06d9996ee11f17c51fcbb70b586Test
https://europepmc.org/articles/PMC4123425Test/

المؤلفون: Liang Zhou, Wesley W. Bodie, Jessica Felthousen, Robert Z. Orlowski, Shuang Chen, Xin Yan Pei, Lora Kramer, Michael W. Sanderson, Leena E. Youssefian, Yun Dai, Steven Grant, Yukie Takabatake

المصدر: PLoS ONE
PLoS ONE, Vol 9, Iss 3, p e89064 (2014)

مصطلحات موضوعية: Cancer Treatment, lcsh:Medicine, Apoptosis, Drug resistance, Signal transduction, ERK signaling cascade, Plasma Cell Disorders, Syndecan 1, Bortezomib, Hematologic Cancers and Related Disorders, 0302 clinical medicine, Molecular cell biology, immune system diseases, hemic and lymphatic diseases, Signaling in Cellular Processes, lcsh:Science, Crosstalk, bcl-2-Associated X Protein, Apoptotic Signaling, 0303 health sciences, Multidisciplinary, biology, Bcl-2-Like Protein 11, Cell Death, Chemistry, Mechanisms of Signal Transduction, Signaling cascades, Antiapoptotic Signaling, Hematology, Boronic Acids, Cell biology, Up-Regulation, Haematopoiesis, bcl-2 Homologous Antagonist-Killer Protein, Oncology, 030220 oncology & carcinogenesis, Pyrazines, Benzamides, Intercellular Signaling Peptides and Proteins, Medicine, biological phenomena, cell phenomena, and immunity, Multiple Myeloma, Bcl-2 Homologous Antagonist-Killer Protein, medicine.drug, Protein Binding, Research Article, Stromal cell, MAPK signaling cascades, Down-Regulation, Signaling Pathways, Cell Growth, 03 medical and health sciences, Bcl-2-associated X protein, Apoptotic signaling cascade, Cell Line, Tumor, Proto-Oncogene Proteins, medicine, Cell Adhesion, Humans, Myelomas and Lymphoproliferative Diseases, neoplasms, Protein Kinase Inhibitors, Biology, 030304 developmental biology, Mitogen-Activated Protein Kinase Kinases, lcsh:R, Mesenchymal stem cell, Membrane Proteins, Cancers and Neoplasms, Mesenchymal Stem Cells, Chemotherapy and Drug Treatment, Cytoprotection, Drug Resistance, Neoplasm, Checkpoint Kinase 1, biology.protein, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, lcsh:Q, Syndecan-1, Apoptosis Regulatory Proteins, Protein Kinases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aecf1022ca785e509cda664737c0b904Test
https://pubmed.ncbi.nlm.nih.gov/24594907Test