التفاصيل البيبلوغرافية
| العنوان: |
Boronic Acid Pairs for Sequential Bioconjugation |
| المؤلفون: |
Mary K. Miller (6557924), Michael J. Swierczynski (11066610), Yuxuan Ding (3625970), Zachary T. Ball (1819597) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Microbiology, Molecular Biology, Biotechnology, Evolutionary Biology, Immunology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sequential cross-coupling, boronic acid structures, EAB, Sequential Bioconjugation Boronic acids, 2- nitro-arylboronic acid, boronic acid, copper-catalyzed processes, stapled peptides, multifunctional probes, NAB groups |
| الوصف: |
Boronic acids can play diverse roles when applied in biological environments, and employing boronic acid structures in tandem could provide new tools for multifunctional probes. This Letter describes a pair of boronic acid functional groups, 2-nitro-arylboronic acid (NAB) and ( E )-alkenylboronic acid (EAB), that enable sequential cross-coupling through stepwise nickel- and copper-catalyzed processes. The selective coupling of NAB groups enables the preparation of stapled peptides, protein–protein conjugates, and other bioconjugates. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Boronic_Acid_Pairs_for_Sequential_Bioconjugation/14899698Test |
| DOI: |
10.1021/acs.orglett.1c01624.s001 |
| الإتاحة: |
https://doi.org/10.1021/acs.orglett.1c01624.s001Test |
| حقوق: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.1F80460A |
| قاعدة البيانات: |
BASE |
