دورية أكاديمية

Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy

التفاصيل البيبلوغرافية
العنوان: Two-Dimensional Biodegradable Black Phosphorus Nanosheets Promote Large Full-Thickness Wound Healing through In Situ Regeneration Therapy
المؤلفون: Xueshan Bai, Renxian Wang, Xiaohua Hu, Qiang Dai, Jianxun Guo, Tongyu Cao, Weili Du, Yuning Cheng, Songxia Xia, Dingding Wang, Liya Yang, Li Teng, Dafu Chen, Yajun Liu
سنة النشر: 2024
مصطلحات موضوعية: Biophysics, Medicine, Cell Biology, Molecular Biology, Immunology, Developmental Biology, Space Science, Biological Sciences not elsewhere classified, situ tissue regeneration, shown great promise, rat large full, plastic surgery repair, perfect clinical outcomes, oas signaling pathway, mitochondrial energy metabolism, challenging clinical problems, thickness skin lesions, situ skin repair, situ skin regeneration, vivo evaluation performed, thickness wound healing, promote cellular function, effectively enhance anti, black phosphorus nanosheets, wound healing, black phosphorus, theoretical basis, subsequent optimization, multiomics analysis, molecular mechanistically
الوصف: Large full-thickness skin lesions have been one of the most challenging clinical problems in plastic surgery repair and reconstruction. To achieve in situ skin regeneration and perfect clinical outcomes, we must address two significant obstacles: angiogenesis deficiency and inflammatory dysfunction. Recently, black phosphorus has shown great promise in wound healing. However, few studies have explored the bio-effects of BP to promote in situ skin regeneration based on its nanoproperties. Here, to investigate whether black phosphorus nanosheets have positive bio-effects on in situ skin repair, we verified black phosphorus nanosheets’ positive effects on angiogenic and anti-inflammatory abilities in vitro. Next, the in vivo evaluation performed on the rat large full-thickness excisional wound splinting model more comprehensively showed that the positive bio-effects of black phosphorus nanosheets are multilevel in wound healing, which can effectively enhance anti-inflammatory ability, angiogenesis, collagen deposition, and skin re-epithelialization. Then, multiomics analysis was performed to explore further the mechanism of black phosphorus nanosheets’ regulation of endothelial cells in depth. Molecular mechanistically, black phosphorus nanosheets activated the JAK-STAT-OAS signaling pathway to promote cellular function and mitochondrial energy metabolism in endothelial cells. This study can provide a theoretical basis for applying two-dimensional black phosphorus nanosheets as nanomedicine to achieve in situ tissue regeneration in complex human pathological microenvironments, guiding the subsequent optimization of black phosphorus.
نوع الوثيقة: article in journal/newspaper
اللغة: unknown
العلاقة: https://figshare.com/articles/journal_contribution/Two-Dimensional_Biodegradable_Black_Phosphorus_Nanosheets_Promote_Large_Full-Thickness_Wound_Healing_through_In_Situ_Regeneration_Therapy/25003824Test
DOI: 10.1021/acsnano.3c11177.s001
الإتاحة: https://doi.org/10.1021/acsnano.3c11177.s001Test
https://figshare.com/articles/journal_contribution/Two-Dimensional_Biodegradable_Black_Phosphorus_Nanosheets_Promote_Large_Full-Thickness_Wound_Healing_through_In_Situ_Regeneration_Therapy/25003824Test
حقوق: CC BY-NC 4.0
رقم الانضمام: edsbas.F300D68D
قاعدة البيانات: BASE