Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial
| العنوان: | Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial |
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| المؤلفون: | Lin, A, Ercumen, A, Benjamin-Chung, J, Arnold, BF, Das, S, Haque, R, Ashraf, S, Parvez, SM, Unicomb, L, Rahman, M, Hubbard, AE, Stewart, CP, Colford, JM, Luby, SP |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 67, iss 10 Lin, A; Ercumen, A; Benjamin-Chung, J; Arnold, BF; Das, S; Haque, R; et al.(2018). Effects of Water, Sanitation, Handwashing, and Nutritional Interventions on Child Enteric Protozoan Infections in Rural Bangladesh: A Cluster-Randomized Controlled Trial.. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 67(10), 1515-1522. doi: 10.1093/cid/ciy320. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/8sd0933sTest |
| بيانات النشر: | eScholarship, University of California, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Giardiasis, Adult, Rural Population, Male, Adolescent, sanitation, Clinical Trials and Supportive Activities, water, Cryptosporidiosis, Nutritional Status, Medical and Health Sciences, Microbiology, Vaccine Related, Feces, Young Adult, hygiene, Clinical Research, parasitic diseases, Prevalence, Humans, Cluster Analysis, 2.2 Factors relating to the physical environment, Aetiology, Child, Preschool, Nutrition, Pediatric, Bangladesh, Protozoan Infections, Entamoebiasis, Prevention, Giardia, Middle Aged, Biological Sciences, Foodborne Illness, Intestinal Diseases, Emerging Infectious Diseases, Infectious Diseases, Clean Water and Sanitation, Parasitic, Female, Pregnant Women, Digestive Diseases, Infection, Hand Disinfection |
| الوصف: | Background:We evaluated effects of individual and combined water, sanitation, handwashing (WSH), and nutritional interventions on protozoan infections in children. Methods:We randomized geographical clusters of pregnant women in rural Bangladesh into chlorinated drinking water, hygienic sanitation, handwashing, nutrition, combined WSH, nutrition plus WSH (N+WSH), or control arms. Participants were not masked. After approximately 2.5 years of intervention, we measured Giardia, Cryptosporidium, and Entamoeba histolytica prevalence and infection intensity by multiplex real-time polymerase chain reaction of child stool. Analysis was intention-to-treat. Results:Between May 2012 and July 2013, we randomized 5551 pregnant women. At follow-up, among 4102 available women, we enrolled 6694 children into the protozoan assessment. We analyzed stool from 5933 children (aged ~31 months) for protozoan infections. Compared with 35.5% prevalence among controls, Giardia infection prevalence was lower in the sanitation (26.5%; prevalence ratio [PR], 0.75 [95% confidence interval {CI}, .64-.88]), handwashing (28.2%; PR, 0.80 [95% CI, .66-.96]), WSH (29.7%; PR, 0.83 [95% CI, .72-.96]), and N+WSH (26.7%; PR, 0.75 [95% CI, .64-.88]) arms. Water and nutrition interventions had no effect. Low prevalence of E. histolytica and Cryptosporidium ( |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1690231342906ff3b865f4fed5f835acTest https://escholarship.org/uc/item/8sd0933sTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..1690231342906ff3b865f4fed5f835ac |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |