CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba
| العنوان: | CRF19_cpx is an evolutionary fit HIV-1 variant strongly associated with rapid progression to AIDS in Cuba |
|---|---|
| المؤلفون: | Andrea-Clemencia Pineda-Peña, Lissette Pérez, Anne-Mieke Vandamme, Ana Belén Pérez, Vivian Kourí, Kristof Theys, Kristel Van Laethem, Sarah Megens, Johan Van Weyenbergh, Jurgen Vercauteren, Yeissel Abrahantes, Ricardo Khouri, Nico Pfeifer, Jorge Luis Tórtora Pérez, Michel Moutschen, Yoan Alemán |
| المساهمون: | Instituto de Higiene e Medicina Tropical (IHMT), Global Health and Tropical Medicine (GHTM), TB, HIV and opportunistic diseases and pathogens (THOP) |
| المصدر: | Abrahantes Rodríguez, Y., Pérez Avila, J., Kouri Cardellá, V., Fonseca Gómez, C., Baly Gil, A., Tápanes Fernandez, T., Factors linked to rapid progression to AIDS in Cuban subjects (2010) Rev. Cubana Med. Trop., 62, pp. 146-153 Repositorio EdocUR-U. Rosario Universidad del Rosario instacron:Universidad del Rosario EBioMedicine EBioMedicine, Vol 2, Iss 3, Pp 244-254 (2015) Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Alpha Interferon, Interleukin 5, Interleukin 6, Macrophage Inflammatory Protein 1Alpha, Interleukin 8, Interleukin 1, Interleukin 2, Human Immunodeficiency Virus 1, Beta 2 Microglobulin, Interleukin 4, Progression to AIDS, Virus Recombination, Young adult, Variant, Monocyte Chemotactic Protein 1, Tumor Necrosis Factor Alpha, Pol Protein, Coinfection, Cuba, Virus Typing, General Medicine, Biological Evolution, Subtyping, Acquired Immune Deficiency Syndrome, Genetic Variability, Interleukin 1Beta, Priority Journal, lcsh:Medicine (General), Viral load, Human, medicine.medical_specialty, Evolution, Sexual Behavior, Immunology, Personas VIH positivas, Neopterin, General Biochemistry, Genetics and Molecular Biology, Article, Disease Course, SDG 3 - Good Health and Well-being, Chemokine Receptor Ccr5, Genetics, Pathogenicity, Humans, Pol Gene Products, Human Immunodeficiency Virus, Progression To Aids, Heterosexuality, Retrospective Studies, Crf19, lcsh:R, Hiv-1, Immunity, Genetic Variation, Mixed Infection, medicine.disease, Virology, CRF19, Grupos sociales, HIV-1, Virus Envelope Protein, Gamma Interferon Inducible Protein 1, Cxcl9 Chemokine, Enfermedad del sida, Rantes, viruses, lcsh:Medicine, Virus Replication, Epidemiology, Enzyme Linked Immunosorbent Assay, Virus Transmission, Cd4 Lymphocyte Count, lcsh:R5-920, Chemokine Receptor Cxcr4, Lymphotoxin, Transmission (medicine), Hiv Infections, Thrush, Genetic Analysis, Viral Load, Reproductive Fitness, Integrase, Female, Antiviral Resistance, Adult, Major Clinical Study, Macrophage Inflammatory Protein 1Beta, Env Gene Products, Human Immunodeficiency Virus, Drug Effects, Biology, Fas Ligand, Human Immunodeficiency Virus 1 Infection, Young Adult, Acquired immunodeficiency syndrome (AIDS), Retrospective Study, Drug Resistance, Viral, medicine, Interleukin 12P7, Controlled Study, Gamma Interferon, Acquired Immunodeficiency Syndrome, Virus Load, Granulocyte Colony Stimulating Factor, biology.protein, Prospective Study |
| الوصف: | BACKGROUND: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection) in Cuba. METHODS: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as > 3 years infected. Clinical, demographic, virological, epidemiological and immunological data were collected. Pol and env sequences were used for subtyping, transmission cluster analysis, and prediction of resistance, co-receptor use and evolutionary fitness. Host, immunological and viral predictors of RP were explored through data mining. FINDINGS: Subtyping revealed 26 subtype B strains, 6 C, 6 CRF18_cpx, 9 CRF19_cpx, 29 BG-recombinants and other subtypes/URFs. All patients infected with CRF19 belonged to the AIDS-RP group. Data mining identified CRF19, oral candidiasis and RANTES levels as the strongest predictors of AIDS-RP. CRF19 was more frequently predicted to use the CXCR4 co-receptor, had higher fitness scores in the protease region, and patients had higher viral load at diagnosis. INTERPRETATION: CRF19 is a recombinant of subtype D (C-part of Gag, PR, RT and nef), subtype A (N-part of Gag, Integrase, Env) and subtype G (Vif, Vpr, Vpu and C-part of Env). Since subtypes D and A have been associated with respectively faster and slower disease progression, our findings might indicate a fit PR driving high viral load, which in combination with co-infections may boost RANTES levels and thus CXCR4 use, potentially explaining the fast progression. We propose that CRF19 is evolutionary very fit and causing rapid progression to AIDS in many newly infected patients in Cuba. publishersversion published |
| وصف الملف: | application/pdf; Electronic-eCollection |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8d11d7fcf7e3a98f141d6c0e46964fTest http://repository.urosario.edu.co/handle/10336/19047Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0b8d11d7fcf7e3a98f141d6c0e46964f |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |