Three New Compounds from the Actinomycete Actinocorallia aurantiaca
| العنوان: | Three New Compounds from the Actinomycete Actinocorallia aurantiaca |
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| المؤلفون: | He-Ping Chen, Chenglin Jiang, Tao Feng, Kai-Yue Han, Rong Huang, Ji-Kai Liu, Xing Wu, Zheng-Hui Li |
| المصدر: | Natural Products and Bioprospecting Natural Products and Bioprospecting, Vol 9, Iss 5, Pp 351-354 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Stereochemistry, Short Communication, Plant Science, Toxicology, medicine.disease_cause, 01 natural sciences, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, lcsh:Botany, Influenza A virus, medicine, Bioorganic chemistry, Actinocorallia aurantiaca, Antiviral activity, Anti-NO activity, EC50, Pharmacology, Natural product, 010405 organic chemistry, Actinomycete, Organic Chemistry, Absolute configuration, Biological activity, 0104 chemical sciences, lcsh:QK1-989, 010404 medicinal & biomolecular chemistry, chemistry, Polyketides, Fermentation, Two-dimensional nuclear magnetic resonance spectroscopy, Food Science |
| الوصف: | Aurantiadioic acids A (1) and B (2), two new furan-containing polyketides, and aurantoic acid A (3), a new natural product, were isolated from the liquid fermentation of the sika deer dung-derived actinomycete Actinocorallia aurantiaca. The structures of the new compounds were established by extensive spectroscopic methods, including 1D & 2D NMR, HRESIMS spectroscopic analysis. The absolute configuration of 3 was assigned by comparison of the specific optical rotations with the reported derivatives. Biological activity evaluations suggested that compounds 1–3 showed weak inhibition on NO production in the murine monocytic RAW 264.7 macrophages with IC50 values of 35.8, 41.8, 45.2 μM, respectively. Compound 3 showed weak inhibition on influenza A virus (A/PuertoRico/8/1934, H1N1) with an EC50 value of 35.9 μM, and a selective index higher than 13.3. |
| تدمد: | 2192-2195 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd13bdd176763c5d6835e8773e4ef2e0Test https://pubmed.ncbi.nlm.nih.gov/31529277Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cd13bdd176763c5d6835e8773e4ef2e0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21922195 |
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