Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4]arene derivative and curcumin for a sustained drug release
| العنوان: | Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4]arene derivative and curcumin for a sustained drug release |
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| المؤلفون: | Salvatore Petralia, Giuseppe Forte, Giuseppe Granata, Grazia M. L. Consoli, Sabrina Conoci |
| المصدر: | Materials science & engineering. C, Biomimetic materials, sensors and systems 111 (2020): 110842. doi:10.1016/j.msec.2020.110842 info:cnr-pdr/source/autori:Giuseppe Granata, Salvatore Petralia, Giuseppe Forte, Sabrina Conoci, Grazia Maria Letizia Consoli/titolo:Injectable supramolecular nanohydrogel from a micellar self-assembling calix[4]arene derivative and curcumin for a sustained drug release/doi:10.1016%2Fj.msec.2020.110842/rivista:Materials science & engineering. C, Biomimetic materials, sensors and systems (Print)/anno:2020/pagina_da:110842/pagina_a:/intervallo_pagine:110842/volume:111 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Models, Molecular, Materials science, Curcumin, Supramolecular chemistry, Bioengineering, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Micelle, Injections, Biomaterials, Drug delivery, Injectable nanohydrogel, Self-assembling calix[4]arene, Calixarenes, Computer Simulation, Drug Stability, Hydrogels, Phenols, Rheology, Spectrophotometry, Ultraviolet, Viscosity, Drug Liberation, Micelles, chemistry.chemical_compound, Models, Self assembling, Ultraviolet, technology, industry, and agriculture, Molecular, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Mechanics of Materials, Spectrophotometry, Drug release, Nanomedicine, 0210 nano-technology, Derivative (chemistry) |
| الوصف: | In the search for soft and smart materials for nanomedicine, which is a present challenge, supramolecular nanohydrogels built on self-assembling low-molecular-weight building blocks attract interest for their structural, mechanical and functional properties. Herein, we describe a supramolecular nanohydrogel formed by a biofriendly micellar self-assembling choline-calix[4]arene derivative in the presence of curcumin, a natural and multitarget pharmacologically relevant drug. Morphology and mechanical properties of the nanohydrogel were investigated, and theoretical simulation performed to model the nanohydrogel structure. The self-healing and injectable nanohydrogel easily formed in PBS medium at physiologic pH, without using additives and organic solvents. The micellar nanohydrogel protected curcumin from rapid chemical and photochemical degradation, and slowly dissolved in curcumin-loaded micelles sustaining the drug release in a low rate. The nanohydrogel which combines the mechanical properties of a hydrogel and the benefits of a nanoscale micelle in drug delivery, appears a promising novel material for drug delivery. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b614c39cedc8ffba6cb31a090bf125c7Test http://hdl.handle.net/20.500.11769/519608Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b614c39cedc8ffba6cb31a090bf125c7 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |