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1دورية أكاديمية
المؤلفون: Lixue Lu, Yafei Huang, Meiqi Song, Nannan Sun, Li Xia, Mingcheng Yu, Meiling Zhao, Ruomeng Qiu, Ji-an Chen, Yunpeng Zhao, Haojie Wang, Huimin Guo, Yan Li, Di Zhu, Yonghui Wang, Qiong Xie
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Biotechnology, Immunology, Cancer, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, sup >+ sup, preclinical tumor models, mouse b16f10 melanoma, llc lung adenocarcinoma, demonstrated robust efficacy, current studies indicate, biaryl amide derivatives, rorγt agonists provide, novel rorγt agonists, 14 b, vivo <, taken together, reachable approach, pharmacokinetic profiles, cancer immunotherapy
الإتاحة: https://doi.org/10.1021/acs.jmedchem.3c01492.s001Test
https://figshare.com/articles/journal_contribution/Discovery_of_Biaryl_Amide_Derivatives_as_Potent_Selective_and_Orally_Bioavailable_ROR_t_Agonists_for_Cancer_Immunotherapy/24591888Test -
2دورية أكاديمية
المؤلفون: Xiuhao Zhao, Wenhua Liang, Yonghui Wang, Ruirong Yi, Lingjie Luo, Weifang Wang, Nannan Sun, Mingcheng Yu, Weijue Xu, Qingfeng Sheng, Li Lu, Jianfeng Pang, Zhibao Lv, Feng Wang
المصدر: Cell & Bioscience, Vol 12, Iss 1, Pp 1-10 (2022)
مصطلحات موضوعية: Neonate, Necrotizing enterocolitis, Intestinal immune, RORγt, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2045-3701Test
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3دورية أكاديمية
المؤلفون: Ji-An Chen (9305742), Hui Ma (290168), Zehui Liu (4023659), Jinlong Tian (5878574), Sisi Lu (6916592), Wenqing Fang (11879351), Shuyin Ze (11879354), Weiqiang Lu (165510), Qiong Xie (709001), Jin Huang (146235), Yonghui Wang (287491)
مصطلحات موضوعية: Biochemistry, Cell Biology, Pharmacology, Biotechnology, Immunology, Cancer, Space Science, Chemical Sciences not elsewhere classified, present study provides, multifactorial autoimmune disease, major clinical challenge, dextran sulfate sodium, may enhance anti, 50 sub, 14d b, potent dual rorγt, vivo <, therapeutic agents, taken together, reduce rorγt, novel framework, inflammatory effects, inflammatory activity, exhibited remarkable, dual rorγt, dihydroorotate dehydrogenase, dependently alleviated, aminobenzothiazole hit, 297 μm, 110 μm
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4دورية أكاديمية
المؤلفون: William P. Gallagher (1508725), John R. Coombs (1334916), Carlos A. Guerrero (1264551), Boguslaw M. Mudryk (11714298), Kishta Katipally (1695961), Candice L. Joe (1588000), Sanjeewa Rupasinghe (11714301), Jason Zhu (2042095), Francisco González-Bobes (1508401)
مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Infectious Diseases, Plant Biology, Virology, Computational Biology, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, dynamic kinetic resolution, 1 kg scale, 2 b, 1 b, synthesized starting, rorγt inhibitor, overall 51, optimized process, hagemann ’, hageman ’, dkr ), cyclohexyl fragment, catalyzed carbonylation, asymmetric synthesis, 7 steps, 5 isolations
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5
المؤلفون: Maxime C M van den Oetelaar, Richard G. Doveston, Femke A. Meijer, Luc Brunsveld, Ella N R Sampers
المساهمون: Chemical Biology, Biomedical Engineering, ICMS Core
المصدر: ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters, 12(4), 631-639. American Chemical Societyمصطلحات موضوعية: Letter, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, Regulator, covalent probes, 01 natural sciences, Biochemistry, Small molecule, 3. Good health, 0104 chemical sciences, Cell biology, Proinflammatory cytokine, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Nuclear receptors, RAR-related orphan receptor gamma, Covalent bond, Drug Discovery, RORγt, allosteric modulators, Binding site
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec5b4f48087443b98c608b5da164207Test
https://doi.org/10.1021/acsmedchemlett.1c00029Test -
6
المؤلفون: Zhao, Xiuhao, Liang, Wenhua, Wang, Yonghui, Yi, Ruirong, Luo, Lingjie, Wang, Weifang, Sun, Nannan, Yu, Mingcheng, Xu, Weijue, Sheng, Qingfeng, Lu, Li, Pang, Jianfeng, Lv, Zhibao, Wang, Feng
المصدر: Cell & Bioscience, Vol 12, Iss 1, Pp 1-10 (2022)
Cell & Bioscienceمصطلحات موضوعية: Neonate, Necrotizing enterocolitis, QH301-705.5, Research, Intestinal immune, RORγt, QD415-436, Biology (General), Biochemistry, digestive system diseases, TP248.13-248.65, General Biochemistry, Genetics and Molecular Biology, Biotechnology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d3fe4da97382fbc51290204ea370be4Test
https://doi.org/10.1186/s13578-021-00739-6Test -
7
المساهمون: Chemical Biology, ICMS Core
المصدر: ChemMedChem, 15(7), 561-565. Wiley-VCH Verlag
Chemmedchemمصطلحات موضوعية: Models, Molecular, Allosteric regulation, Nuclear Receptors, Crystallography, X-Ray, Ligands, 01 natural sciences, Biochemistry, Allosteric Regulation, RAR-related orphan receptor gamma, Drug Discovery, Inverse agonist, Humans, General Pharmacology, Toxicology and Pharmaceutics, Mode of action, Pharmacology, Orphan receptor, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Drug discovery, Communication, Organic Chemistry, ROR gamma t, Nuclear Receptor Subfamily 1, Group F, Member 3, Small molecule, Communications, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Nuclear receptor, Allosteric Modulators, Molecular Medicine, Pyrazoles, RORγt, Structure Elucidation
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fcba1c971c6b9aa22e800eba9a321fdTest
http://www.scopus.com/inward/record.url?scp=85081956966&partnerID=8YFLogxKTest -
8
المؤلفون: Iris A. Leijten-van de Gevel, Kim H.N. van Herk, Rens M.J.M. de Vries, Nicolaas J. Ottenheym, Christian Ottmann, Luc Brunsveld
المساهمون: Chemical Biology, Biomedical Engineering, ICMS Core
المصدر: Bioorganic and Medicinal Chemistry, 68:116877. Elsevier
مصطلحات موضوعية: Protein Structure, Secondary, Indazoles, PPARγ, Nuclear Receptor Subfamily 1, Member 3/metabolism, Nuclear Receptors, Partial Agonism, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Nuclear Receptor Subfamily 1, Group F, Member 3/metabolism, Indazoles/pharmacology, Nuclear Receptor Subfamily 1, Group F, Member 3, Ligands, Biochemistry, Protein Structure, Secondary, PPAR gamma, Group F, Drug Discovery, Molecular Medicine, RORγt, Molecular Biology, Co-crystal structure, PPAR gamma/agonists
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1d72ab9bf80ef661399d3521d34fcadTest
https://doi.org/10.1016/j.bmc.2022.116877Test -
9صورة
المؤلفون: Steven A. Saenz (11668881), Andrea Local (11668884), Tiffany Carr (11668887), Arvind Shakya (120984), Shivsmriti Koul (11668890), Haiqing Hu (96108), Lisa Chourb (11668893), Justin Stedman (11668896), Jenna Malley (10811582), Laura Akullian D’Agostino (8633694), Veerabahu Shanmugasundaram (294662), John Malona (11668899), C. Eric Schwartz (1944748), Lisa Beebe (11668902), Meghan Clements (11668905), Ganesh Rajaraman (3940082), John Cho (11668908), Lan Jiang (57811), Alex Dubrovskiy (8633670), Matt Kreilein (11668911), Roman Shimanovich (1637992), Lawrence G. Hamann (1436563), Laure Escoubet (11668914), J. Michael Ellis (1648321)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, retinoic acid receptor, pancreatic ductal adenocarcinoma, div >< p, attractive therapeutic target, associated gene expression, numerous autoimmune diseases, delay tumor volume, inhibit th17 differentiation, inhibit tumor formation, rorγt block th17, tumor formation, autoimmune disorders, tumor growth, tumor effects, th17 cells, vivo <, vitro <, transcription factors, rorγt inhibitors, rorγt functions
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10صورة
المؤلفون: Steven A. Saenz (11668881), Andrea Local (11668884), Tiffany Carr (11668887), Arvind Shakya (120984), Shivsmriti Koul (11668890), Haiqing Hu (96108), Lisa Chourb (11668893), Justin Stedman (11668896), Jenna Malley (10811582), Laura Akullian D’Agostino (8633694), Veerabahu Shanmugasundaram (294662), John Malona (11668899), C. Eric Schwartz (1944748), Lisa Beebe (11668902), Meghan Clements (11668905), Ganesh Rajaraman (3940082), John Cho (11668908), Lan Jiang (57811), Alex Dubrovskiy (8633670), Matt Kreilein (11668911), Roman Shimanovich (1637992), Lawrence G. Hamann (1436563), Laure Escoubet (11668914), J. Michael Ellis (1648321)
مصطلحات موضوعية: Biochemistry, Cell Biology, Genetics, Molecular Biology, Pharmacology, Immunology, Cancer, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, retinoic acid receptor, pancreatic ductal adenocarcinoma, div >< p, attractive therapeutic target, associated gene expression, numerous autoimmune diseases, delay tumor volume, inhibit th17 differentiation, inhibit tumor formation, rorγt block th17, tumor formation, autoimmune disorders, tumor growth, tumor effects, th17 cells, vivo <, vitro <, transcription factors, rorγt inhibitors, rorγt functions