المؤلفون: Hannu Koistinen, Ruusu‐Maaria Kovanen, Morley D. Hollenberg, Antoine Dufour, Evette S. Radisky, Ulf‐Håkan Stenman, Jyotsna Batra, Judith Clements, John D. Hooper, Eleftherios Diamandis, Oliver Schilling, Antti Rannikko, Tuomas Mirtti

المصدر: IUBMB Life. 75:493-513

مصطلحات موضوعية: Clinical Biochemistry, Genetics, Cell Biology, Molecular Biology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f96050bce11ef690957c5cf6a0c067f3Test
https://doi.org/10.1002/iub.2700Test

المؤلفون: Muhammad N. Ahmed (3963893), Matti Wahlsten (83368), Jouni Jokela (83367), Matthias Nees (229635), Ulf-Håkan Stenman (1846159), Danillo O. Alvarenga (3697969), Tomas Strandin (153541), Kaarina Sivonen (83370), Antti Poso (1760140), Perttu Permi (150487), Mikko Metsä-Ketelä (1415065), Hannu Koistinen (631779), David P. Fewer (139548)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Inorganic Chemistry, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, results substantially broaden, bioinformatic analysis demonstrated, attractive drug lead, 12 cyanobacterial genera, long residence time, human serine proteases, unexpected chemical diversity, natural products produced, 50 , suomilide also inhibited, natural products, chemical diversity, residence times, suomilide belongs, selective inhibitors, potent inhibitor, potent inhibition

العلاقة: https://figshare.com/articles/journal_contribution/Potent_Inhibitor_of_Human_Trypsins_from_the_Aeruginosin_Family_of_Natural_Products/16826244Test

الإتاحة: https://doi.org/10.1021/acschembio.1c00611.s002Test

المؤلفون: Ulf-Håkan Stenman, Hannu Koistinen, Paco Hulpiau, Cedric Hermans, Benedicte Y. De Winter, Nikita Hanning, Ingrid De Meester, Hannah Ceuleers, Maya Berg, Joris G. De Man, Anne-Marie Lambeir, Michelle De bruyn

المساهمون: University of Helsinki, Department of Clinical Chemistry and Hematology

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 10711, p 10711 (2021)
International journal of molecular sciences
International Journal of Molecular Sciences
Volume 22
Issue 19

مصطلحات موضوعية: Male, medicine.medical_treatment, neurotensin, Inflammatory bowel disease, 0302 clinical medicine, Biology (General), Spectroscopy, chemistry.chemical_classification, 0303 health sciences, General Medicine, Trypsin, Colitis, thrombin, 3. Good health, Computer Science Applications, trypsin, Chemistry, Biochemistry, 030211 gastroenterology & hepatology, protease activity, Disease Susceptibility, medicine.drug, Proteases, QH301-705.5, Receptors, Proteinase-Activated, IBD, β-endorphin, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Thrombin, IBS, medicine, Animals, Amino Acid Sequence, Physical and Theoretical Chemistry, Molecular Biology, Biology, QD1-999, Acute colitis, 030304 developmental biology, Protease, Organic Chemistry, medicine.disease, Inflammatory Bowel Diseases, digestive system diseases, Rats, Disease Models, Animal, Enzyme, chemistry, enkephalins, inflammation, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Proteolysis, 3111 Biomedicine, Peptides, PAR, Biomarkers

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7721792eaab3bae8b68e82bd936b0633Test
https://www.mdpi.com/1422-0067/22/19/10711Test

المؤلفون: Hannu Koistinen, Riitta Koistinen, Kristina Hotakainen, Anna Lempiäinen, Kalle Jokelainen, Martti Färkkilä, Ulf-Håkan Stenman

المساهمون: Department of Clinical Chemistry and Hematology, HUS Abdominal Center, Faculty Common Matters (Faculty of Biology and Environmental Sciences), University of Helsinki, HUSLAB, Medicum, Gastroenterologian yksikkö, Centre of Excellence in Complex Disease Genetics, Department of Medicine, Clinicum

المصدر: Analytical Biochemistry. 648:114681

مصطلحات موضوعية: Immunoassay, Prss3, Primary sclerosing cholangitis, Biophysics, Cell Biology, digestive system, Biochemistry, digestive system diseases, Isoenzymes, Trypsinogen, 1182 Biochemistry, cell and molecular biology, Bile, Humans, Trypsin, Molecular Biology, Trypsinogen-4

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d6d13a9a7e73e626b36f13c26e854aTest
https://doi.org/10.1016/j.ab.2022.114681Test

المؤلفون: Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed

المساهمون: Department of Microbiology, Faculty of Agriculture and Forestry, Department of Food and Nutrition, Cyanobacteria research, Department of Clinical Chemistry and Hematology, Department of Virology, Medicum, Viral Zoonosis Research Unit, Helsinki Institute of Sustainability Science (HELSUS), Chemistry Teacher Education Unit (Department of Chemistry) (-2009), Institute of Biotechnology, HUS Abdominal Center, Faculty Common Matters (Faculty of Biology and Environmental Sciences), Microbial Natural Products

المصدر: ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611Test

مصطلحات موضوعية: Proteases, serine proteases, 116 Chemical sciences, proteaasi, luonnontuotteet, 01 natural sciences, Biochemistry, Genome, proteomiikka, Serine, 03 medical and health sciences, Cell Line, Tumor, Gene cluster, inhibitors, Humans, IC50, Gene, trypsiinit, 030304 developmental biology, Cell Proliferation, inhibiittorit, Serine protease, 0303 health sciences, Biological Products, biology, biokemia, 010405 organic chemistry, Cell growth, Chemistry, bioinformatiikka, General Medicine, Articles, seriiniproteaasi, 0104 chemical sciences, 3. Good health, syöpäsolut, Genes, Bacterial, biology.protein, Molecular Medicine, proteases, syöpätaudit, proteiinit, Trypsin Inhibitors, Azabicyclo Compounds, Nodularia, Aeruginosins

وصف الملف: application/pdf; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2Test
http://urn.fi/URN:NBN:fi:jyu-202110205299Test

المؤلفون: Aaro Kasurinen (6061466), Alli Laitinen (838079), Arto Kokkola (838080), Ulf-Håkan Stenman (476955), Camilla Böckelman (837603), Caj Haglund (476956)

مصطلحات موضوعية: Biochemistry, Medicine, Biotechnology, Immunology, Cancer, Infectious Diseases, Virology, proteolytic target enzyme, multivariable survival analysis, methods :, limits serine proteases, introduction :, helsinki university hospital, conclusions :, 93 – 13, 7 – 61, 7 – 34, 32 – 3, p >< b, crp )., 037 )., preoperative serum tat, medium serum tat, high serum tat, 4 – 40, 2 may function, high serum tati, results :, associated trypsin inhibitor, 6 – 59

العلاقة: https://figshare.com/articles/dataset/Tumor-associated_trypsin_inhibitor_TATI_and_tumor-associated_trypsin-2_TAT-2_predict_outcomes_in_gastric_cancer/11925567Test

الإتاحة: https://doi.org/10.6084/m9.figshare.11925567.v2Test

المؤلفون: Maija Lahtela-Kakkonen, Kristian Meinander, Henna Ylikangas, Ale Närvänen, Hannu Koistinen, Erik A.A. Wallén, Ulf-Håkan Stenman

المصدر: Biological Chemistry. 397:1229-1235

مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Angiogenesis, Clinical Biochemistry, Peptide, Biochemistry, 03 medical and health sciences, Prostate cancer, Antigen, Prostate, Drug Discovery, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Chemistry, Prostatic Neoplasms, Kallikrein, Prostate-Specific Antigen, medicine.disease, Small molecule, Prostate-specific antigen, 030104 developmental biology, medicine.anatomical_structure, Proteolysis, Peptides

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58d173e15f9d820c1d774aafe5155e7aTest
https://doi.org/10.1515/hsz-2016-0189Test

المؤلفون: Peter Goettig, Brigitta Elsässer, Bettina Mayer, Oliver Schilling, Hans Brandstetter, Martin L. Biniossek, Ulf-Håkan Stenman, Hannu Koistinen

المصدر: Biological chemistry. 399(9)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Arginine, Clinical Biochemistry, Lysine, Cleavage (embryo), Biochemistry, Substrate Specificity, 03 medical and health sciences, 0302 clinical medicine, Aspartic acid, medicine, Humans, Trypsin, Amino Acid Sequence, Threonine, Molecular Biology, Peptide sequence, Fluorescent Dyes, Alanine, Chemistry, Isoenzymes, 030104 developmental biology, 030220 oncology & carcinogenesis, Sequence Alignment, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaa3cf13f1f31556f8fbab209c5b49aTest
https://pubmed.ncbi.nlm.nih.gov/29883318Test

المؤلفون: Suvi Ravela, Leena Kylänpää, Hannu Koistinen, Leena Valmu, Jakob Stenman, Outi Itkonen, Mykola Domanskyy, Esa Hämäläinen, Ulf-Håkan Stenman, Outi Lindström

المساهمون: Clinicum, University of Helsinki, Department of Diagnostics and Therapeutics, Medicum, Department of Surgery, II kirurgian klinikka, Institute for Molecular Medicine Finland, HUSLAB, HUS Abdominal Center

المصدر: Analytical and bioanalytical chemistry. 410(6)

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, CHRONIC-PANCREATITIS, Biochemistry, Primer extension, Chromatography, Affinity, Mass Spectrometry, Analytical Chemistry, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, TATI, SPINK1, Quantitative LC-MS assay, Liquid chromatography–mass spectrometry, Limit of Detection, medicine, Humans, Gene, Pancreatic Secretory Trypsin Inhibitor, Carcinoma, Renal Cell, Aged, Detection limit, Aged, 80 and over, MUTATIONS, Middle Aged, medicine.disease, Molecular biology, GENE, Zygosity, Kidney Neoplasms, 3. Good health, 030104 developmental biology, chemistry, Pancreatitis, Trypsin Inhibitor, Kazal Pancreatic, 030220 oncology & carcinogenesis, Acute Disease, Mutation, Immunocapture, Female, 3111 Biomedicine, N34S, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9396ba82eb095eea2eefe8def5e35976Test
https://pubmed.ncbi.nlm.nih.gov/29318362Test

المؤلفون: Outi Itkonen, Ulf-Håkan Stenman

المصدر: Clinica Chimica Acta. 431:260-269

مصطلحات موضوعية: Trypsin inhibitor, Clinical Biochemistry, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, PstI, Biomarkers, Tumor, medicine, Animals, Humans, Pancreatic Secretory Trypsin Inhibitor, 030304 developmental biology, 0303 health sciences, biology, Biochemistry (medical), General Medicine, medicine.disease, Trypsin, Protease inhibitor (biology), 3. Good health, medicine.anatomical_structure, Pancreatitis, Trypsin Inhibitor, Kazal Pancreatic, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Biomarker (medicine), Pancreas, Biomarkers, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420e37305f886878d31a38c4a72ef2a7Test
https://doi.org/10.1016/j.cca.2014.02.014Test