المؤلفون: Muhammad N. Ahmed (3963893), Matti Wahlsten (83368), Jouni Jokela (83367), Matthias Nees (229635), Ulf-Håkan Stenman (1846159), Danillo O. Alvarenga (3697969), Tomas Strandin (153541), Kaarina Sivonen (83370), Antti Poso (1760140), Perttu Permi (150487), Mikko Metsä-Ketelä (1415065), Hannu Koistinen (631779), David P. Fewer (139548)

مصطلحات موضوعية: Biophysics, Biochemistry, Microbiology, Genetics, Pharmacology, Biotechnology, Evolutionary Biology, Cancer, Inorganic Chemistry, Hematology, Infectious Diseases, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, results substantially broaden, bioinformatic analysis demonstrated, attractive drug lead, 12 cyanobacterial genera, long residence time, human serine proteases, unexpected chemical diversity, natural products produced, 50 , suomilide also inhibited, natural products, chemical diversity, residence times, suomilide belongs, selective inhibitors, potent inhibitor, potent inhibition

العلاقة: https://figshare.com/articles/journal_contribution/Potent_Inhibitor_of_Human_Trypsins_from_the_Aeruginosin_Family_of_Natural_Products/16826244Test

الإتاحة: https://doi.org/10.1021/acschembio.1c00611.s002Test

المؤلفون: Ulf-Håkan Stenman, Jouni Jokela, Hannu Koistinen, Kaarina Sivonen, Antti Poso, Matti Wahlsten, Perttu Permi, David P. Fewer, Tomas Strandin, Danillo O. Alvarenga, Matthias Nees, Mikko Metsä-Ketelä, Muhammad N. Ahmed

المساهمون: Department of Microbiology, Faculty of Agriculture and Forestry, Department of Food and Nutrition, Cyanobacteria research, Department of Clinical Chemistry and Hematology, Department of Virology, Medicum, Viral Zoonosis Research Unit, Helsinki Institute of Sustainability Science (HELSUS), Chemistry Teacher Education Unit (Department of Chemistry) (-2009), Institute of Biotechnology, HUS Abdominal Center, Faculty Common Matters (Faculty of Biology and Environmental Sciences), Microbial Natural Products

المصدر: ACS Chemical Biology
Ahmed, M N, Wahlsten, M, Jokela, J, Nees, M, Stenman, U-H, Alvarenga, D O, Strandin, T, Sivonen, K, Poso, A, Permi, P, Metsä-Ketelä, M, Koistinen, H & Fewer, D P 2021, ' Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products ', ACS chemical biology, vol. 16, no. 11, pp. 2537–2546 . https://doi.org/10.1021/acschembio.1c00611Test

مصطلحات موضوعية: Proteases, serine proteases, 116 Chemical sciences, proteaasi, luonnontuotteet, 01 natural sciences, Biochemistry, Genome, proteomiikka, Serine, 03 medical and health sciences, Cell Line, Tumor, Gene cluster, inhibitors, Humans, IC50, Gene, trypsiinit, 030304 developmental biology, Cell Proliferation, inhibiittorit, Serine protease, 0303 health sciences, Biological Products, biology, biokemia, 010405 organic chemistry, Cell growth, Chemistry, bioinformatiikka, General Medicine, Articles, seriiniproteaasi, 0104 chemical sciences, 3. Good health, syöpäsolut, Genes, Bacterial, biology.protein, Molecular Medicine, proteases, syöpätaudit, proteiinit, Trypsin Inhibitors, Azabicyclo Compounds, Nodularia, Aeruginosins

وصف الملف: application/pdf; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48dab7b1e75d58c8c8668582248387f2Test
http://urn.fi/URN:NBN:fi:jyu-202110205299Test

المؤلفون: Adolfo Rivero-Müller, Matthias Nees

المصدر: EMBO Reports

مصطلحات موضوعية: 0303 health sciences, 4. Education, S&S: History & Philosophy of Science, Radiation-Protective Agents, Methods & Resources, Empirical Research, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Empirical research, ComputingMilieux_COMPUTERSANDEDUCATION, Genetics, Humans, Engineering ethics, Amino Acid Sequence, Sociology, Students, Science & Society, Molecular Biology, 030217 neurology & neurosurgery, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c5147895e6789c89ccd28ec97af6d4aTest
https://doi.org/10.15252/embr.201949004Test

المؤلفون: Sang Gu Kang, Shiv Bharadwaj, Vivek Dhar Dwivedi, Kyung Eun Lee, Umesh Yadava, Matthias Nees

المصدر: Journal of Molecular Liquids. 311:113322

مصطلحات موضوعية: chemistry.chemical_classification, MMP3, medicine.diagnostic_test, Chemistry, Proteolysis, 02 engineering and technology, Matrix metalloproteinase, 010402 general chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 01 natural sciences, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Extracellular matrix, Enzyme, Biochemistry, Materials Chemistry, medicine, Gelatinase, Physical and Theoretical Chemistry, 0210 nano-technology, Spectroscopy, Ganoderiol, ADME

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7436b164a01f802826152bffd20a0c76Test
https://doi.org/10.1016/j.molliq.2020.113322Test

المؤلفون: Jesse Mattsson, Matthias Nees, Natalia Tong Ochoa, Riina Minna Väänänen, Terhi Tallgren, Peter J. Boström, Anders Bjartell, Pekka Taimen, Saeid Alinezhad, Kim Pettersson, Malin Åkerfelt, Yifeng Li

المصدر: PLoS ONE, Vol 11, Iss 5, p e0155901 (2016)
PLoS ONE

مصطلحات موضوعية: 0301 basic medicine, Male, rho GTP-Binding Proteins, Candidate gene, Gene Expression, lcsh:Medicine, Bioinformatics, Biochemistry, Metastasis, Prostate cancer, 0302 clinical medicine, Prostate, Medicine and Health Sciences, Small interfering RNAs, ta318, Organ Cultures, Reproductive System Procedures, lcsh:Science, Multidisciplinary, Prostate Cancer, Prostate Diseases, Middle Aged, Radical Prostatectomy, 3. Good health, Gene Expression Regulation, Neoplastic, Nucleic acids, Organoids, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, RNA Interference, Biological Cultures, Anatomy, Research Article, PCA3, Calcium Channels, L-Type, Urology, Surgical and Invasive Medical Procedures, Biology, Research and Analysis Methods, Transfection, 03 medical and health sciences, Exocrine Glands, Coenzyme A Ligases, medicine, Biomarkers, Tumor, Genetics, Gene silencing, Humans, Non-coding RNA, Molecular Biology Techniques, Molecular Biology, Aged, Homeodomain Proteins, Prostatectomy, ta3126, Biology and life sciences, Surgical Excision, lcsh:R, Cancer, Prostatic Neoplasms, Correction, Cancers and Neoplasms, medicine.disease, Gene regulation, Genitourinary Tract Tumors, 030104 developmental biology, Cancer cell, 1-Alkyl-2-acetylglycerophosphocholine Esterase, RNA, Prostate Gland, lcsh:Q, Laminin, Biomarkers, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f221120cae865b6962c0c530616481Test
http://europepmc.org/articles/PMC4873225?pdf=renderTest

المؤلفون: J R Jones, S-Y Lu, V. P. Shevchenko, I. Yu. Nagaev, N. F. Myasoedov, A. B. Susan, R. Anderskerskevitz, F. W. Birke, K-H. Switek, Peter Wiegerinck, Olaf Post, Leontine Hofstede, Marcel van den Heuvel, U. Pleiss, D. Seidel, K.-H. Switek, H. Braunger, Dietrich Seidel, Rainer Schlecker, Thomas Moenius, Max-Peter Seiler, Joachim Nozulak, Paul Burtscher, Mario Almi, Simone Guelfi, Maria Luisa Navacchia, C. Felicini, D. Giribone, A. Pignatti, E. Fontana, J. W. McGrath, B. Peric Simov, W. Preusser, J. P. Quinn, S. Schmidt, A. Woschek, F. Wuggenig, F. Hammerschmidt, H. Spies, Jochen Maas, Volker Krone, Frank Diehl, Johannes Coy, J�rg Hoheisel, Magnus von Knebel Doeberitz, Matthias Nees, Alfred Klett

المصدر: Journal of Labelled Compounds and Radiopharmaceuticals. 45:1159-1198

مصطلحات موضوعية: chemistry.chemical_classification, Tetramethylammonium, Ketone, biology, Isotope, Stereochemistry, Organic Chemistry, biology.organism_classification, Biochemistry, Saccharomyces, Analytical Chemistry, Isotopomers, chemistry.chemical_compound, chemistry, Homogeneous, Labelling, Drug Discovery, Radiology, Nuclear Medicine and imaging, Spectroscopy

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::04ce5f4df1cb1aad0a0e4853b5347144Test
https://doi.org/10.1002/jlcr.658Test

المؤلفون: Bengt Fadeel, Matthias Nees, Alfonso E. Garcia-Bennett

المصدر: Garcia-Bennett, A, Nees, M & Fadeel, B 2011, ' In search of the Holy Grail : Folate-targeted nanoparticles for cancer therapy ', Biochemical Pharmacology, vol. 81, no. 8, pp. 976-984 . https://doi.org/10.1016/j.bcp.2011.01.023Test

مصطلحات موضوعية: Cancer therapy, Antineoplastic Agents, 02 engineering and technology, Pharmacology, 010402 general chemistry, 01 natural sciences, Biochemistry, folic acid, Nanoparticle, Targeted nanoparticles, SDG 3 - Good Health and Well-being, Neoplasms, Humans, Medicine, Drug Carriers, business.industry, Folate Receptors, GPI-Anchored, targeted delivery, Cancer, toxicity, 021001 nanoscience & nanotechnology, medicine.disease, Endocytosis, 0104 chemical sciences, 3. Good health, Holy Grail, Folic acid, Folate receptor, Cancer cell, Drug delivery, Cancer research, Nanoparticles, 0210 nano-technology, business, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0263c113484dc75a37c09d810fa777d8Test
https://cris.vtt.fi/en/publications/bdd2f728-7ee2-463a-8564-af45a54f4321Test

المؤلفون: Matthias Nees, Rolf Inge Skotheim

المصدر: Skotheim, R & Nees, M 2007, ' Alternative splicing in cancer : Noise, functional, or systematic? ', International Journal of Biochemistry and Cell Biology, vol. 39, no. 7-8, pp. 1432-1449 . https://doi.org/10.1016/j.biocel.2007.02.016Test

مصطلحات موضوعية: Spliceosome, Systems biology, Cancer progression, Computational biology, Biology, Biochemistry, SDG 3 - Good Health and Well-being, Neoplasms, medicine, Humans, Gene, Alternative splicing of mRNAs, Genetics, Gene Expression Profiling, Alternative splicing, CD44, Cancer, Computational Biology, Cell Biology, medicine.disease, Alternative Splicing, Pre-mRNA processing, RNA splicing, biology.protein, DNA microarray

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6210a4195ab4028ccbbaf96fc1eb0ed2Test
https://cris.vtt.fi/en/publications/1bfad75a-1429-44f1-95c7-059e668798a2Test