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المؤلفون: Taku Satoh, Yukio Kato, Hiroko Toyoda, Kazumi Shin, Hiroshi Arakawa, Shinji Sugiura, Takumi Kawanishi, Toshiyuki Kanamori, Yasuyuki Sakai
المصدر: Lab on a Chip. 20:537-547
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Triazolam, CYP3A, Kinetic analysis, Pharmacokinetic modeling, Biomedical Engineering, Glucuronidation, Bioengineering, Pharmacology, Models, Biological, Biochemistry, Pharmacokinetics, Lab-On-A-Chip Devices, Tumor Cells, Cultured, medicine, Humans, Chemistry, General Chemistry, Metabolism, Microfluidic Analytical Techniques, Kinetics, Liver, Caco-2 Cells, Drug metabolism, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de83fafa864a3f0c9b781361713dabdTest
https://doi.org/10.1039/c9lc00884eTest -
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المؤلفون: Ikumi Tamai, Hiroshi Arakawa, Shijie Wen
المصدر: Biochemical and biophysical research communications. 581
مصطلحات موضوعية: Male, Gout, THP-1 Cells, Interleukin-1beta, Primary Cell Culture, Biophysics, Inflammation, Hyperuricemia, CD38, Nicotinamide adenine dinucleotide, Biochemistry, Models, Biological, chemistry.chemical_compound, Mice, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Membrane Glycoproteins, Cluster of differentiation, Macrophages, hemic and immune systems, Cell Biology, medicine.disease, NAD, ADP-ribosyl Cyclase 1, Cell biology, Uric Acid, Mice, Inbred C57BL, Enzyme, chemistry, Gene Expression Regulation, Female, NAD+ kinase, medicine.symptom, Crystallization, Intracellular, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b952d5c585edbca1bd84e9bb0e4fbbTest
https://pubmed.ncbi.nlm.nih.gov/34637964Test -
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المؤلفون: Kyoko Ondo, Miki Nakajima, Masataka Nakano, Hiroshi Arakawa, Tatsuki Fukami
المصدر: Biochemical pharmacology. 175
مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Monosaccharide Transport Proteins, Glucuronidation, Endoplasmic Reticulum, digestive system, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Glucuronides, Humans, Glucuronosyltransferase, Pharmacology, Gene knockdown, Chemistry, Endoplasmic reticulum, HEK 293 cells, Transporter, Molecular biology, Glucuronosyltransferase activity, 030104 developmental biology, HEK293 Cells, 030220 oncology & carcinogenesis, Gene Knockdown Techniques, Microsome, Hepatocytes, Uridine Diphosphate Glucuronic Acid
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3028a8440d0bed4880f16d4b1c61e1Test
https://pubmed.ncbi.nlm.nih.gov/32179043Test -
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المؤلفون: Karin Araya, Hiroshi Arakawa, Yukio Kato, Yusuke Masuo, Tomohiko Wakayama
المصدر: The FASEB Journal. 33
مصطلحات موضوعية: Endoplasmic reticulum membrane, Chemistry, Genetics, medicine, Glucuronidation, Transporter, Molecular Biology, Biochemistry, Bumetanide, Biotechnology, medicine.drug, Cell biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1357bb774922163a4182ec604984d0eeTest
https://doi.org/10.1096/fasebj.2019.33.1_supplement.507.9Test -
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المؤلفون: Hiroshi Arakawa, Miki Nakajima, Kenji Mishiro, Yongjie Zhang, Masataka Nakano, Hiroki Hashizume, Kanji Mishima, Tatsuki Fukami
المصدر: Biochemical Pharmacology. 183:114303
مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Ketoprofen, Adolescent, Mefenamic acid, Coenzyme A, Flurbiprofen, Glucuronidation, Spodoptera, Pharmacology, Biochemistry, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Coenzyme A Ligases, Sf9 Cells, medicine, Animals, Humans, Aged, Liver injury, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Loxoprofen, Middle Aged, medicine.disease, Isoenzymes, 030104 developmental biology, Liver, 030220 oncology & carcinogenesis, Female, Glucuronide, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010e70df300ff96b9b6eebce68f6c88dTest
https://doi.org/10.1016/j.bcp.2020.114303Test -
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المؤلفون: Naoki Ishiguro, Ikumi Washio, Ikumi Tamai, Yukio Kato, Takeo Nakanishi, Hikaru Kubo, Angelina Yukiko Staub, Natsumi Matsuoka, Noritaka Nakamichi, Hiroshi Arakawa
المصدر: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)مصطلحات موضوعية: 0301 basic medicine, Male, lcsh:Medicine, Biology, Kidney, Tritium, 030226 pharmacology & pharmacy, Article, 03 medical and health sciences, chemistry.chemical_compound, Inhibitory Concentration 50, 0302 clinical medicine, Cell polarity, medicine, Animals, Humans, lcsh:Science, Epithelial polarity, Mice, Knockout, Mice, Inbred ICR, Multidisciplinary, Reabsorption, lcsh:R, Kidney metabolism, Cell Polarity, Ergothioneine, Membrane Proteins, Transporter, Apical membrane, Mice, Inbred C57BL, Kinetics, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, chemistry, Biochemistry, lcsh:Q, Carrier Proteins
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3169a959b0e8a83fde455d9028a467Test
http://europepmc.org/articles/PMC5634478Test -
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المؤلفون: Hiroki Kamioka, Hiroshi Arakawa, Sachi Saito, Kaori Morimoto, Masahiko Kanagawa, Takuo Ogihara, Kentaro Yano
المصدر: Drug Metabolism and Pharmacokinetics. 29:470-474
مصطلحات موضوعية: Male, Administration, Oral, Pharmaceutical Science, Transfection, Peptide Transporter 1, Intestinal absorption, chemistry.chemical_compound, Intestinal mucosa, In vivo, Membrane Transport Modulators, Animals, Humans, Pharmacology (medical), Intestinal Mucosa, Rats, Wistar, Pharmacology, Alanine, Glycylglycine, Dipeptide, Symporters, biology, Chemistry, Peptide transporter 1, Biological Transport, Dipeptides, Hydrogen-Ion Concentration, Molecular biology, In vitro, Biochemistry, Injections, Intravenous, Hepatocytes, Microsomes, Liver, biology.protein, Half-Life, HeLa Cells
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c553cd66a1c5b8bdaeb8c8b09b4a3005Test
https://doi.org/10.2133/dmpk.dmpk-14-rg-047Test -
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المؤلفون: Shikha Sharma, Julian E. Sale, Teonchit Nuamchit, Hiroshi Arakawa, Jean-Marie Buerstedde, Kathryn H. Steele, Nicholas P.J. Brindle
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Directed Evolution, Somatic hypermutation, Ligand Binding Protein, Plasma protein binding, Protein Engineering, Biochemistry, Receptor tyrosine kinase, Angiopoietin-2, 03 medical and health sciences, 0302 clinical medicine, Cell surface receptor, Humans, Molecular Biology, 030304 developmental biology, 0303 health sciences, Endothelial Cell, biology, HEK 293 cells, Cell Surface Receptor, Cell Biology, Angiopoietin receptor, Molecular biology, Receptor, TIE-2, Ligand-binding Protein, Cell biology, Protein Structure, Tertiary, HEK293 Cells, Ectodomain, 030220 oncology & carcinogenesis, Protein Structure and Folding, biology.protein, Angiogenesis, Directed Molecular Evolution, Protein Binding
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1831936e20d8708d4a4802c0db100abTest
http://europepmc.org/articles/PMC3829167Test -
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المؤلفون: Ikumi Tamai, Chihiro Yanagihara, Takeo Nakanishi, Atsushi Mizokami, Hiroshi Arakawa, Tomohiko Wakayama, Keiichi Kawai, Tomohiro Nishimoto, Mikio Namiki
المصدر: Biochemical Pharmacology. 84:1070-1077
مصطلحات موضوعية: Male, medicine.medical_specialty, Organic anion transporter 1, DHEAS, OATP1A2, Organic Anion Transporters, Androgen Receptor Positive, urologic and male genital diseases, Biochemistry, Prostate cancer, Steroid sulfatase, Cell Line, Tumor, Internal medicine, LNCaP, medicine, Humans, RNA, Messenger, Pharmacology, Gene knockdown, biology, Reverse Transcriptase Polymerase Chain Reaction, Cell growth, Chemistry, Gene Expression Profiling, Prostatic Neoplasms, Androgen Antagonists, medicine.disease, Androgen receptor, Endocrinology, Receptors, Androgen, Cell culture, Cancer research, biology.protein, Sulfonic Acids, Cell Division, hormones, hormone substitutes, and hormone antagonists
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b414c094130dc2d59731df89543efcfTest
https://doi.org/10.1016/j.bcp.2012.07.026Test -
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المؤلفون: Shuji Noguchi, Tadaaki Tokida, Hironori Suzuki, Yoshinori Satow, Hiroshi Arakawa, Mariko Hashimoto
المصدر: Acta Crystallographica Section F Structural Biology and Crystallization Communications. 66:1591-1595
مصطلحات موضوعية: Biophysics, Plasma protein binding, Crystallography, X-Ray, Biochemistry, law.invention, Crystal, Structural Biology, law, Heat shock protein, Genetics, Humans, Crystallization, Chemistry, Resolution (electron density), X-ray, HSP40 Heat-Shock Proteins, Condensed Matter Physics, Protein Structure, Tertiary, enzymes and coenzymes (carbohydrates), Crystallography, Crystallization Communications, health occupations, Electrophoresis, Polyacrylamide Gel, CTD, Peptides, Protein Binding, Binding domain
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b38a8d25afd03f36a565f293aaf7828Test
https://doi.org/10.1107/s1744309110034081Test