المؤلفون: Frank Madeo, Sylvère Durand, Deborah Lefevre, Mélanie Viltard, Christine Leroy, Maria Perez-Lanzon, Guido Kroemer, Gérard Friedlander, Fanny Aprahamian

المساهمون: Gestionnaire, Hal Sorbonne Université, Fondation pour la Recherche en Physiologie [Brussels, Belgium], Institut Gustave Roussy (IGR), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Université Paris Cité (UPCité), Université Paris-Saclay, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Karl-Franzens-Universität Graz, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), University of Science & Technology of China [Suzhou], Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Plateforme de métabolomique, Direction de la recherche [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), GK is supported by the Ligue contre le Cancer (équipe labellisée), Agence National de la Recherche (ANR) – Projets blancs, ANR under the frame of E-Rare-2, the ERA-Net for Research on Rare Diseases, Association pour la Recherche sur le Cancer (ARC), Cancéropôle Ile-de-France, Chancelerie des universités de Paris (Legs Poix), Fondation pour la Recherche Médicale (FRM), a donation by Elior, European Research Area Network on Cardiovascular Diseases (ERA-CVD, MINOTAUR), Gustave Roussy Odyssea, the European Union Horizon 2020 Project Oncobiome, Fondation Carrefour, High-end Foreign Expert Program in China (GDW20171100085 and GDW20181100051), Institut National du Cancer (INCa), Inserm (HTE), Institut Universitaire de France, LeDucq Foundation, the LabEx Immuno-Oncology (ANR-18-IDEX-0001), the RHU Torino Lumière, the Seerave Foundation, the SIRIC Stratified Oncology Cell DNA Repair and Tumor Immune Elimination (SOCRATE), and the SIRIC Cancer Research and Personalized Medicine (CARPEM). F.M. is grateful to the Austrian Science Fund FWF (SFB LIPOTOX F3007 & F3012, W1226, P29203, P29262, P27893, P 31727 and the Austrian Federal Ministry of Education, Science and Research and the University of Graz for grants 'Unkonventionelle Forschung-InterFast' and 'flysleep' (BMWFW 80.109/0001-WF/V/3b/2015) as well as the field of excellence program BioHealth. We acknowledge support from NAWI Graz and the BioTechMed-Graz flagship project 'EPIAge'. M.V. is grateful to the Ecole Nationale Vétérinaire d’Alfort (EnvA) and the Association De Prévoyance Santé (ADPS) partners of Allianz, for their invaluable help in establishing and funding the animal facility. M.P.L. is supported by Fondation pour la Recherche Médicale (FRM FDT201904008383)., Université de Paris (UP), Karl-Franzens-Universität [Graz, Autriche]

المصدر: Aging (Albany NY)
Aging
Aging, 2019, 11 (14), pp.4783-4800. ⟨10.18632/aging.102116⟩
Aging, Impact Journals, 2019, 11 (14), pp.4783-4800. ⟨10.18632/aging.102116⟩

مصطلحات موضوعية: autophagy, Aging, Rodent, [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine.medical_treatment, media_common.quotation_subject, Longevity, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Metabolomics, Species Specificity, biology.animal, spermidine, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], medicine, Metabolome, microbiota, Animals, 030304 developmental biology, media_common, meta-organism, 0303 health sciences, biology, Vitamin E, Mole Rats, catabolism, Laboratory mouse, Cell Biology, Rats, Spermidine, Metabolic pathway, antioxidants, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Priority Research Paper

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23f1d10e895a99e530c64b5a17b012c7Test
http://europepmc.org/articles/PMC6682510Test

المؤلفون: Rudolf Zechner, Frank Madeo, Dagmar Kratky

المصدر: Nature Reviews Molecular Cell Biology. 18:671-684

مصطلحات موضوعية: 0301 basic medicine, Cytosolic lipolysis, Adipose Tissue, White, Lipolysis, Adipose tissue, White adipose tissue, Fatty Acids, Nonesterified, Biology, Energy homeostasis, 03 medical and health sciences, Cytosol, Metabolic Diseases, Animals, Humans, Molecular Biology, Triglycerides, nutritional and metabolic diseases, Lipid metabolism, Cell Biology, 030104 developmental biology, Lipotoxicity, Biochemistry, lipids (amino acids, peptides, and proteins), Energy Metabolism, Lysosomes, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4288dbbeb6c6ef23c7ef7de2e00a80eTest
https://doi.org/10.1038/nrm.2017.76Test

المؤلفون: Francesca Castoldi, Jelena Tadic, Katharina Kainz, Maria Chiara Maiuri, Elisa E. Baracco, David Enot, Alexis Chery, V. Izzo, Frank Madeo, Sylvère Durand, Guido Kroemer, Federico Pietrocola

المساهمون: Baracco, E. E., Castoldi, F., Durand, S., Enot, D. P., Tadic, J., Kainz, K., Madeo, F., Chery, A., Izzo, V., Maiuri, M. C., Pietrocola, F., Kroemer, G.

المصدر: Aging (Albany NY)

مصطلحات موضوعية: Cell death, Programmed cell death, Aging, Metabolite, Metabolomic, Oxidative phosphorylation, Mitochondrion, Mass Spectrometry, Oxidative Phosphorylation, Ketoglutaric Acid, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Autophagy, Humans, 030304 developmental biology, Acetyl CoA, 0303 health sciences, Acetyl-CoA, Cell Biology, metabolomics, Mitochondria, Citric acid cycle, Biochemistry, chemistry, Ketoglutaric Acids, Krebs cycle, 030217 neurology & neurosurgery, Intracellular, Priority Research Paper, Human

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8156940b0cd422c0d232b1583310d698Test
http://hdl.handle.net/11588/840485Test

المؤلفون: Frank Madeo, Christian Mühlfeld, Marie-Christin Wierich, Julia Schipke, Christina Brandenberger, Simon Sedej, Mahmoud Abdellatif, Tobias Eisenberg

المصدر: Experimental gerontology. 119

مصطلحات موضوعية: 0301 basic medicine, Cardiac function curve, Male, Vascular Endothelial Growth Factor A, medicine.medical_specialty, Aging, Cardiotonic Agents, Endothelium, Spermidine, Stereology, Left ventricular hypertrophy, Biochemistry, Microcirculation, Muscle hypertrophy, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Internal medicine, Coronary Circulation, Genetics, Medicine, Animals, Myocytes, Cardiac, Molecular Biology, business.industry, Myocardium, Cell Biology, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, chemistry, Microvessels, Hypertrophy, Left Ventricular, business, Polyamine, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c874a14929cfc3d2f208061e20fe853Test
https://pubmed.ncbi.nlm.nih.gov/31133178Test

المؤلفون: Alexis Chery, Sylvère Durand, Lorenzo Galluzzi, Federico Pietrocola, Frank Madeo, Guido Kroemer, Erika Vacchelli, David Enot, Mireia Niso-Santano

المصدر: Cell Cycle. 14:2399-2407

مصطلحات موضوعية: Aging, Spermidine, Palmitates, Spermine, Nicotinamide adenine dinucleotide, Mass Spectrometry, Mice, Phosphatidylinositol 3-Kinases, chemistry.chemical_compound, Autophagy, Animals, Metabolomics, Phosphatidylinositol, Amino Acids, Muscle, Skeletal, Molecular Biology, chemistry.chemical_classification, Principal Component Analysis, biology, Myocardium, Extra View, Cell Biology, NAD, Amino acid, Mice, Inbred C57BL, Enzyme, Liver, chemistry, Biochemistry, Sirtuin, biology.protein, Female, NAD+ kinase, Oleic Acid, Signal Transduction, Developmental Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4040bca3f26d6b350f4ed06acea7b09Test
https://doi.org/10.1080/15384101.2015.1064206Test

المؤلفون: Federico Pietrocola, Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Frank Madeo, Guido Kroemer

المصدر: Cell Metabolism. 21(6):805-821

مصطلحات موضوعية: Anabolism, Physiology, Metabolite, Allosteric regulation, Mitosis, Second Messenger Systems, Epigenesis, Genetic, chemistry.chemical_compound, Allosteric Regulation, Acetyl Coenzyme A, Autophagy, Animals, Humans, Molecular Biology, chemistry.chemical_classification, biology, Cell Biology, Metabolic intermediate, Cell biology, Enzyme, Histone, chemistry, Biochemistry, Acetylation, Second messenger system, biology.protein, Energy Metabolism

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e1bae506d0ac074535268cdb35a1b2Test

المؤلفون: Frank Madeo, V. Izzo, Rodrigo Troncoso, Nektarios Tavernarakis, Nicolas Dupont, Maria Chiara Maiuri, Gérard Pierron, Patrice Codogno, Amena BenYounès, Maria Markaki, Patrick Rockenfeller, Francesco Cecconi, Guillermo Mariño, Mireia Niso-Santano, José Manuel Bravo-San Pedro, Sergio Lavandero, Shoaib Ahmad Malik, Federico Pietrocola, Guido Kroemer, Chantal Bauvy, Oliver Kepp, Kariman Chaba, Valentina Cianfanelli, Lorenzo Galluzzi, Valentina Sica, Heimo Wolinski, Francis Harper

المساهمون: Niso Santano, Mireia, Malik, Shoaib Ahmad, Pietrocola, Federico, Bravo San Pedro, José Manuel, Mariño, Guillermo, Cianfanelli, Valentina, Ben Younès, Amena, Troncoso, Rodrigo, Markaki, Maria, Sica, Valentina, Izzo, Valentina, Chaba, Kariman, Bauvy, Chantal, Dupont, Nicola, Kepp, Oliver, Rockenfeller, Patrick, Wolinski, Heimo, Madeo, Frank, Lavandero, Sergio, Codogno, Patrice, Harper, Franci, Pierron, Gérard, Tavernarakis, Nektario, Cecconi, Francesco, Maiuri, MARIA CHIARA, Galluzzi, Lorenzo, Kroemer, Guido

المصدر: Europe PubMed Central

مصطلحات موضوعية: Autophagy, Fatty Acids, ATG5, LC3, Beclin 1, Palmitic Acid, Inbred C57BL, Transgenic, Palmitic acid, ATG5, GFP‐LC3, RFP‐FYVE, beclin 1, brefeldin A, Animals, Apoptosis Regulatory Proteins, Autophagy, Caenorhabditis elegans, Cells, Cultured, Fatty Acids, Unsaturated, Female, HeLa Cells, Humans, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Oleic Acid, Saccharomyces cerevisiae, Up-Regulation, chemistry.chemical_compound, Unsaturated, Cultured, General Neuroscience, Fatty Acids, BECN1, Brefeldin A, Cell biology, Biochemistry, symbols, Beclin-1, Settore BIO/06, Cells, Biology, General Biochemistry, Genetics and Molecular Biology, symbols.namesake, Lipolysis, Molecular Biology, General Immunology and Microbiology, AMPK, Golgi apparatus, Have You Seen?, chemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc48a15c939454834ccf0373f86a6df6Test
https://doi.org/10.15252/embj.201489363Test

المؤلفون: Alban Longchamp, William B. Mair, Christopher Hine, Yue Zhang, Frank Madeo, James R. Mitchell, Lear E. Brace, Jose Humberto Treviño-Villarreal, Christoph Ruckenstuhl, Byung Cheon Lee, Pedro Mejia, Eylul Harputlugil, C. Keith Ozaki, Rui Wang, Vadim N. Gladyshev

المصدر: Cell. 160(1-2):132-144

مصطلحات موضوعية: Male, NF-E2-Related Factor 2, Transsulfuration pathway, mTORC1, Biology, Kidney, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Life Expectancy, Methionine, Stress, Physiological, Yeasts, Animals, Cysteine, Hydrogen Sulfide, Caenorhabditis elegans, 030304 developmental biology, Caloric Restriction, 2. Zero hunger, Mice, Knockout, 0303 health sciences, Biochemistry, Genetics and Molecular Biology(all), Cystathionine gamma-lyase, Cystathionine gamma-Lyase, Translation (biology), equipment and supplies, Cystathionine beta synthase, Biological Evolution, Diet, Drosophila melanogaster, chemistry, Biochemistry, Liver, Reperfusion Injury, biology.protein, Female, Signal transduction, Transcriptome, 030217 neurology & neurosurgery, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac664bf6eee57b5ce511f1cf40649560Test

المؤلفون: Christoph Ruckenstuhl, Frank Madeo, Michael Neuhaus, Rafal Koziel, Rudolf J. Wiesner, Maria Bust, Christine Netzberger, Pidder Jansen-Dürr, Eva Albertini

المصدر: Aging Cell

مصطلحات موضوعية: Senescence, Aging, Respiratory chain, Mitochondrion, Biology, medicine.disease_cause, fibroblast, chemistry.chemical_compound, medicine, Animals, Humans, cellular senescence, Fibroblast, methionine, chemistry.chemical_classification, Reactive oxygen species, Methionine, Age Factors, Translation (biology), Original Articles, Cell Biology, Fibroblasts, Diploidy, Mitochondria, Cell biology, Disease Models, Animal, Oxidative Stress, medicine.anatomical_structure, Biochemistry, chemistry, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f237748a42c465ed4fbd235e0272c1Test
https://doi.org/10.1111/acel.12266Test

المؤلفون: Federico Pietrocola, Tobias Eisenberg, Guido Kroemer, Frank Madeo

المصدر: Nature Reviews Drug Discovery. 13:727-740

مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, fungi, Autophagy, Lysine, Caloric theory, Acetyltransferases, General Medicine, Biology, Enzyme, chemistry, Biochemistry, Acetylation, Drug Discovery, Acetyl coenzyme, Cellular proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5624dd3c20931c7beaf956c254337634Test
https://doi.org/10.1038/nrd4391Test