المؤلفون: F Nambu, T. Okegawa, T. Shiraji, S. Murakata, A. Kawasaki, M. Sawada, S. Ikeda, Omawari N

المصدر: Prostaglandins. 39:623-637

مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.drug_class, Guinea Pigs, Indomethacin, Mepyramine, 6-Ketoprostaglandin F1 alpha, Histamine Release, Biochemistry, Bordetella pertussis, Guinea pig, Thromboxane A2, chemistry.chemical_compound, Endocrinology, Internal medicine, medicine, Animals, Cyclooxygenase Inhibitors, Anaphylaxis, Pyrilamine, medicine.diagnostic_test, Pulmonary Alveoli, Thromboxane B2, Bronchoalveolar lavage, Acrylates, chemistry, Methacrylates, Immunization, lipids (amino acids, peptides, and proteins), Bronchoconstriction, medicine.symptom, H1 antagonist, Histamine, circulatory and respiratory physiology, medicine.drug

الوصف: We investigated the effects of OKY-046, a potent and selective thromboxane A2 (TxA2) synthetase inhibitor, on anaphylactic bronchoconstriction and release of chemical mediators into airway lumen in sensitized guinea pigs in vivo. OKY-046 dose-dependently inhibited antigen-induced anaphylactic bronchoconstriction with or without mepyramine, a histamine H1 antagonist. In the presence of mepyramine, OKY-046 (300 mg/kg, p.o.) elicited significant reductions in histamine (1 min) and TxB2 increases (1-15 min) in bronchoalveolar lavage (BAL) fluid but significantly increased the plasma level of 6-keto-PGF1 alpha, a stable PGI2 metabolite, after antigen challenge. On the contrary, indomethacin only significantly reduced increases in TxB2 levels. These results suggest that the antiasthmatic effect of OKY-046 is probably due to inhibition of TxA2 synthesis and suppression of histamine release via a PGI2 shunting mechanism.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4efc62fc217290b88de5132390ab7e1Test
https://doi.org/10.1016/0090-6980Test(90)90023-o

المؤلفون: Shin Tanaka, F. Nambu, Z. Nambu

المصدر: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 148:S93

مصطلحات موضوعية: Physiology, Ecology, Zoology, Embryonic diapause, Biology, Molecular Biology, Biochemistry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::15506b62204174e2aaa4f81de181f6afTest
https://doi.org/10.1016/j.cbpa.2007.06.242Test

المؤلفون: Shin Tanaka, F. Nambu, Z. Nambu

المصدر: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 148:S92

مصطلحات موضوعية: Physiology, Ecology, Cold treatment, Embryonic diapause, Biology, Molecular Biology, Biochemistry, Gene, Cell biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ecb526dff13122e677db55b52fae0a9dTest
https://doi.org/10.1016/j.cbpa.2007.06.239Test

المؤلفون: Z Nambu, F Nambu, Shin Tanaka

المصدر: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 124:S143

مصطلحات موضوعية: Cloning, Biochemistry, Physiology, Biology, Trehalase, Molecular Biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e2510047270d0c831373a67968d4f84Test
https://doi.org/10.1016/s1095-6433Test(99)90565-2

المؤلفون: F Nambu, Z Nambu, Shin Tanaka

المصدر: Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology. 124:S142

مصطلحات موضوعية: Messenger RNA, Physiology, medicine.drug_class, Chemistry, medicine, Monoclonal antibody, Molecular Biology, Biochemistry, Molecular biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::30e1e719d32c1ac6c370e0675d55457dTest
https://doi.org/10.1016/s1095-6433Test(99)90561-5