نتائج البحث - "John S. Millar"

1

Endothelial lipase mediates efficient lipolysis of triglyceride-rich lipoproteins

المؤلفون: Michael G. Levin, Jeffrey T. Billheimer, John S. Millar, Sumeet A. Khetarpal, Joseph Park, Takashi Kuwano, Daniel J. Rader, Pradeep Natarajan, Derek Klarin, Cecilia Vitali, Papasani V. Subbaiah, Dhavamani Sugasini, Akhil Pampana

المصدر: PLoS Genetics, Vol 17, Iss 9, p e1009802 (2021)
PLoS Genetics

مصطلحات موضوعية: Endothelial lipase, Cancer Research, Hydrolases, QH426-470, Biochemistry, Fats, Mice, chemistry.chemical_compound, Medicine and Health Sciences, Lipases, Phospholipids, Genetics (clinical), chemistry.chemical_classification, Lipoprotein lipase, biology, Hydrolysis, Chemical Reactions, Postprandial Period, Lipids, Enzymes, Chemistry, Physical Sciences, lipids (amino acids, peptides, and proteins), Energy source, Research Article, Polyunsaturated fatty acid, medicine.medical_specialty, Lipolysis, Lipoproteins, Mutation, Missense, Diet, High-Fat, Internal medicine, Genetics, medicine, Animals, Humans, Lipase, Molecular Biology, Triglycerides, Ecology, Evolution, Behavior and Systematics, Nutrition, Triglyceride, Biology and Life Sciences, Proteins, Human Genetics, Diet, Endocrinology, chemistry, Liposomes, Enzymology, biology.protein, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af2e6182a90739aa574f13c5345882bTest
https://doi.org/10.1371/journal.pgen.1009802Test

2

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages—Brief Report

المؤلفون: Daniel J. Rader, Jeffrey T. Billheimer, Michael C. Phillips, Melanie A. Hachet, Muredach P. Reilly, Hongfeng Jiang, Babak Razani, Wenjun Li, Junichiro Tohyama, Jianting Shi, Robert C. Bauer, Hanrui Zhang, Chenyi Xue, John S. Millar

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology. 37:2156-2160

مصطلحات موضوعية: 0301 basic medicine, Time Factors, Genotype, Apolipoprotein B, Induced Pluripotent Stem Cells, Interleukin-1beta, Biology, Transfection, Gene Expression Regulation, Enzymologic, Article, 03 medical and health sciences, chemistry.chemical_compound, Sterol esterase, Humans, Chemokine CCL5, Gene Editing, chemistry.chemical_classification, Apolipoprotein A-I, Interleukin-6, Hydrolysis, Macrophages, Cell Differentiation, Hep G2 Cells, Sterol Esterase, Molecular biology, Lipoproteins, LDL, HEK293 Cells, Phenotype, 030104 developmental biology, Enzyme, ATP Binding Cassette Transporter 1, chemistry, Biochemistry, Gene Knockdown Techniques, ABCA1, Apolipoprotein B-100, Proteolysis, biology.protein, Cholesteryl ester, Cholesterol Esters, CRISPR-Cas Systems, Lysosomes, Cardiology and Cardiovascular Medicine, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e55c3c605b1e38c9b963a926dc5a5aTest
https://doi.org/10.1161/atvbaha.117.310023Test

3

A novel approach to measuring macrophage-specific reverse cholesterol transport in vivo in humans

المصدر: Journal of Lipid Research, Vol 58, Iss 4, Pp 752-762 (2017)

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Agonist, Adolescent, medicine.drug_class, QD415-436, 030204 cardiovascular system & hematology, Biology, Pharmacology, Biochemistry, Feces, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, medicine, Animals, Humans, Distribution (pharmacology), Macrophage, Liver X receptor, Research Articles, Aged, Liver X Receptors, Macrophages, Cholesterol, HDL, Reverse cholesterol transport, Biological Transport, Cell Biology, Mononuclear phagocyte system, Middle Aged, Atherosclerosis, lipoproteins, Cholesterol, 030104 developmental biology, Liver, chemistry, high density lipoprotein, Immunology, Cholesteryl ester, Nanoparticles, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a62d8e481687a201a84014e01be9e8cTest
https://doi.org/10.1194/jlr.m075226Test

4

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

المؤلفون: William R. Lagor, Junichiro Tohyama, Daniel J. Rader, Tomoyuki Yasuda, Eleonora Cipollari, Xin Bi, Jeffrey T. Billheimer, John S. Millar, Hannah J Szapary, Takashi Kuwano, Nicholas N. Lyssenko

المصدر: Journal of Lipid Research, Vol 58, Iss 4, Pp 731-741 (2017)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, QD415-436, High-Density Lipoproteins, Pre-beta, 030204 cardiovascular system & hematology, Biochemistry, Excretion, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, In vivo, Internal medicine, Phospholipid transfer protein, medicine, Animals, Humans, Phospholipid Transfer Proteins, Research Articles, Sequence Deletion, phospholipid transfer protein activity, Cholesterol, Cholesterol, HDL, Reverse cholesterol transport, Biological Transport, Cell Biology, Metabolism, Dependovirus, high density lipoprotein/metabolism, animal models, macrophages, 030104 developmental biology, Gene Expression Regulation, Liver, chemistry, lipids (amino acids, peptides, and proteins), Efflux, ATP binding cassette transporter A1, atherosclerosis, Lipoproteins, HDL, Ex vivo

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8b06193acd151667bb831e703d32c2Test
http://www.sciencedirect.com/science/article/pii/S0022227520338505Test

5

Lack of MTTP Activity in Pluripotent Stem Cell-Derived Hepatocytes and Cardiomyocytes Abolishes apoB Secretion and Increases Cell Stress

المؤلفون: Ali Javaheri, Evanthia E. Pashos, Edward E. Morrisey, Donna M. Conlon, Wenli Yang, Ying Liu, Jahangir Iqbal, Daniel J. Rader, Stephen A. Duncan, Xin Bi, John S. Millar, Robert A. Hegele, Marina Cuchel, Jianting Shi, Hailey I. Edelstein, Katherine J. Slovik, M. Mahmood Hussain

المصدر: Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein B, Induced Pluripotent Stem Cells, General Biochemistry, Genetics and Molecular Biology, Microsomal triglyceride transfer protein, Article, 03 medical and health sciences, apoB, Stress, Physiological, iPSC-derived hepatocytes and cardiomyocytes, medicine, Humans, Secretion, Myocytes, Cardiac, abetaliproteinemia, Induced pluripotent stem cell, lcsh:QH301-705.5, Apolipoproteins B, Gene Editing, ABL, biology, lipid accumulation, Abetalipoproteinemia, Lipid metabolism, medicine.disease, cardiac stress, Cell biology, 030104 developmental biology, Phenotype, lcsh:Biology (General), Biochemistry, biology.protein, Hepatocytes, lipids (amino acids, peptides, and proteins), Carrier Proteins, Intracellular

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca22ad42cbd699b2109eefcd7e177f6dTest
https://pubmed.ncbi.nlm.nih.gov/28514664Test

6

Cell lipid metabolism modulators 2-bromopalmitate, D609, monensin, U18666A and probucol shift discoidal HDL formation to the smaller-sized particles: implications for the mechanism of HDL assembly

المؤلفون: Fiona M. La, Michael C. Phillips, Angel X. Xiao, Duyen Quach, Chongren Tang, Daniel J. Rader, Cecilia Vitali, Nicholas N. Lyssenko, John S. Millar

المصدر: Biochimica et biophysica acta. 1861(12 Pt)

مصطلحات موضوعية: 0301 basic medicine, Bridged-Ring Compounds, Apolipoprotein B, Probucol, Palmitates, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Mice, Tangier disease, Thiocarbamates, Cell Line, Tumor, medicine, Animals, Humans, Monensin, Particle Size, Molecular Biology, Phospholipids, chemistry.chemical_classification, 030102 biochemistry & molecular biology, biology, Apolipoprotein A-I, Cholesterol, Macrophages, Cell Membrane, nutritional and metabolic diseases, Thiones, Lipid metabolism, Cell Biology, medicine.disease, Lipid Metabolism, Norbornanes, 030104 developmental biology, RAW 264.7 Cells, Biochemistry, chemistry, ABCA1, biology.protein, Fatty Acids, Unsaturated, lipids (amino acids, peptides, and proteins), Androstenes, Lipoproteins, HDL, medicine.drug, Polyunsaturated fatty acid, Lipoprotein, ATP Binding Cassette Transporter 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb7f9c87aab37682146dec8f6b0e6afTest
https://pubmed.ncbi.nlm.nih.gov/27671775Test

7

Identification of the Active Form of Endothelial Lipase, a Homodimer in a Head-to-Tail Conformation

المؤلفون: Dawn Marchadier, John S. Millar, Tom J. Petty, Daniel J. Rader, Nathalie Griffon, Karen O. Badellino, Jane M. Glick, Jeffrey T. Billheimer, Weijin Jin, Jeffery G. Saven, Ellis S. Kempner

المصدر: Journal of Biological Chemistry. 284:23322-23330

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb5e4915285a91e2c1f2f55bb606cc13Test
https://doi.org/10.1074/jbc.m109.037002Test

8

Effects of cholesteryl ester transfer protein inhibition on apolipoprotein A-II-containing HDL subspecies and apolipoprotein A-II metabolism

المؤلفون: Ernst J. Schaefer, Bela F. Asztalos, John S. Millar, Chorthip Nartsupha, Megan L. Wolfe, Margaret E. Brousseau, James P. Mancuso, Margaret R. Diffenderfer, Daniel J. Rader, Andres Digenio

المصدر: Journal of Lipid Research, Vol 50, Iss 7, Pp 1456-1462 (2009)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4ebed048da3574d3f4abf0ef51803bTest
https://doi.org/10.1194/jlr.p800037-jlr200Test

9

Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism

المؤلفون: Peter M. Schaefer, Aisha Wilson, Gregory G. Dolnikowski, Ernst J. Schaefer, John S. Millar, Daniel J. Rader, Margaret E. Brousseau, Jeffrey S. Cohn, Margaret R. Diffenderfer, Andres Digenio, James P. Mancuso, Chorthip Nartsupha, Megan L. Wolfe, P. Hugh R. Barrett, Francine K. Welty

المصدر: Journal of Lipid Research, Vol 49, Iss 3, Pp 543-549 (2008)

مصطلحات موضوعية: Apolipoprotein E, Male, medicine.medical_specialty, Very low-density lipoprotein, Atorvastatin, QD415-436, Lipoproteins, VLDL, digestive system, Biochemistry, chemistry.chemical_compound, Endocrinology, Apolipoproteins E, Internal medicine, Cholesterylester transfer protein, medicine, polycyclic compounds, Humans, Pyrroles, Single-Blind Method, triglyceride, Enzyme Inhibitors, CETP inhibitor, very low density lipoproteins, Triglyceride, biology, Anticholesteremic Agents, Torcetrapib, nutritional and metabolic diseases, lipoprotein kinetics, Cell Biology, Metabolism, Cholesterol Ester Transfer Proteins, Kinetics, chemistry, Heptanoic Acids, low density lipoproteins, biology.protein, Quinolines, Drug Therapy, Combination, Female, lipids (amino acids, peptides, and proteins), medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13397cab2cf390ed2f87709168fcc89aTest
http://www.sciencedirect.com/science/article/pii/S0022227520424125Test

10

Endothelial lipase is less effective at influencing HDL metabolism in vivo in mice expressing apoA-II

المؤلفون: Uli C. Broedl, Ilia V. Fuki, John S. Millar, Daniel J. Rader, Weijun Jin

المصدر: Journal of Lipid Research, Vol 47, Iss 10, Pp 2191-2197 (2006)

مصطلحات موضوعية: Apolipoprotein E, Endothelial lipase, medicine.medical_specialty, Very low-density lipoprotein, high density lipoprotein metabolism, Apolipoprotein B, Blotting, Western, Genetic Vectors, Apolipoprotein A-II, Mice, Transgenic, QD415-436, transgenic mice, Phospholipase, Transfection, Biochemistry, Adenoviridae, Mice, Endocrinology, high density lipoprotein containing apolipoprotein A-I but no apolipoprotein A-II, In vivo, Internal medicine, polycyclic compounds, medicine, Animals, Humans, biology, Chemistry, nutritional and metabolic diseases, Lipase, Cell Biology, high density lipoprotein containing both apolipoprotein A-I and apolipoprotein A-II, biology.protein, lipids (amino acids, peptides, and proteins), Apolipoprotein C2, Lipoproteins, HDL

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d0bdd5d949cea1bf8c23cf98a021d3Test
https://doi.org/10.1194/jlr.m600036-jlr200Test

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