دورية أكاديمية
Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes
| العنوان: | Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes |
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| المؤلفون: | Hinshaw, Ling, Dadlani, Vikash, Mallad, Ashwini, Bharucha, Adil, Basu, Rita, Geske, Jennifer R., Carter, Rickey E., Basu, Ananda, Kudva, Yogish C., SCHIAVON, MICHELE, DALLA MAN, CHIARA, COBELLI, CLAUDIO |
| المساهمون: | Hinshaw, Ling, Schiavon, Michele, Dadlani, Vikash, Mallad, Ashwini, DALLA MAN, Chiara, Bharucha, Adil, Basu, Rita, Geske, Jennifer R., Carter, Rickey E., Cobelli, Claudio, Basu, Ananda, Kudva, Yogish C. |
| بيانات النشر: | Endocrine Society |
| سنة النشر: | 2016 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Endocrinology, Diabetes and Metabolism, Biochemistry, Clinical Biochemistry, Biochemistry (medical) |
| الوصف: | Context: Early postprandial hyperglycemia and delayed hypoglycemia remain major problems in current management of type 1 diabetes (T1D). Objective: Our objective was to investigate the effects of pramlintide, known to suppress glucagon and delay gastric emptying, on postprandial glucose fluxes in T1D. Design: This was a single-center, inpatient, randomized, crossover study. Patients: Twelve patients with T1D who completed the study were analyzed. Interventions: Subjects were studied on two occasions with or without pramlintide. Triple tracer mixed-meal method and oral minimal model were used to estimate postprandial glucose turnover and insulin sensitivity (S-1). Integrated liver insulin sensitivity was calculated based on glucose turnover. Plasma glucagon and insulin were measured. Main Outcome Measure: Glucose turnover and S, were the main outcome measures. Results: With pramlintide, 2-hour postprandial glucose, insulin, glucagon, glucose turnover, and S, indices showed: plasma glucose excursions were reduced (difference in incremental area under the curve [iAUC], 444.0 mMmin, P = .0003); plasma insulin concentrations were lower (difference in iAUC, 7642.0 pMmin; P = .0099); plasma glucagon excursions were lower (difference in iAUC, 1730.6 pg/mImin; P = .0147); meal rate of glucose appearance was lower (difference in lAUC: 1196.2 mu M/kg fat free mass [FF[W]; P = .0316), endogenous glucose production was not different (difference in iAUC: 105.5 mu M/kg FFM; P = .5842), rate of glucose disappearance was lower (difference in iAUC: 1494.2 mu M/kg FFM; P = .0083). S-i and liver insulin sensitivity were not different between study visits (P > .05). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/26930181; info:eu-repo/semantics/altIdentifier/wos/WOS:000378819700008; volume:101; issue:5; firstpage:1954; lastpage:1962; numberofpages:9; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; http://hdl.handle.net/11577/3228980Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84969776578 |
| DOI: | 10.1210/jc.2015-3952 |
| الإتاحة: | https://doi.org/10.1210/jc.2015-3952Test http://hdl.handle.net/11577/3228980Test |
| رقم الانضمام: | edsbas.36A7D2BC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1210/jc.2015-3952 |
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