يعرض 1 - 10 نتائج من 14 نتيجة بحث عن '"colony stimulating factor 1"', وقت الاستعلام: 0.75s تنقيح النتائج
  1. 1
    Evaluation of carbon-11 labeled 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide as PET tracer for imaging of CSF-1R expression in the brain

    المؤلفون: Bin Shen, Esther J.M. Kooijman, Albert D. Windhorst, Frederick T. Chin, Madina Nezam, Samantha T. Reyes, Berend van der Wildt

    المساهمون: Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging

    المصدر: Bioorganic and Medicinal Chemistry, 42:116245. Elsevier Limited
    van der Wildt, B, Nezam, M, Kooijman, E J M, Reyes, S T, Shen, B, Windhorst, A D & Chin, F T 2021, ' Evaluation of carbon-11 labeled 5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide as PET tracer for imaging of CSF-1R expression in the brain ', Bioorganic and Medicinal Chemistry, vol. 42, 116245 . https://doi.org/10.1016/j.bmc.2021.116245Test

    مصطلحات موضوعية: Tariquidar, Clinical Biochemistry, Pharmaceutical Science, Receptor, Macrophage Colony-Stimulating Factor, Pharmacology, 01 natural sciences, Biochemistry, Colony stimulating factor 1 receptor, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Carbon Radioisotopes, Molecular Biology, IC50, Trifluoromethyl, Nicotinamide, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Radiosynthesis, Brain, In vitro, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Positron-Emission Tomography, Molecular Medicine, Ex vivo, medicine.drug

    وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6407f64f503e7d9f00f9d31aa43890Test
    https://pubmed.ncbi.nlm.nih.gov/34119698Test


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  2. 2
    Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952

    المؤلفون: Yasunori Hase, Kazutaka Ikegashira, Hiromasa Hashimoto, Takayuki Yamasaki, Iichiro Kawahara, Taku Ikenogami, Yoshihisa Koga, Koji Inagaki, Naoki Miyagawa, Takahiro Oka

    المصدر: Bioorganic & Medicinal Chemistry Letters. 29:873-877

    مصطلحات موضوعية: Models, Molecular, Cellular activity, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Arthritis, Pharmacology, 01 natural sciences, Biochemistry, Colony stimulating factor 1 receptor, Mice, chemistry.chemical_compound, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Receptor, Protein Kinase Inhibitors, Molecular Biology, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, medicine.disease, Arthritis, Experimental, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Gene Expression Regulation, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Azetidines, Molecular Medicine, Collagen

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f442336db72895a98e9e75673b64cf0Test
    https://doi.org/10.1016/j.bmcl.2019.02.006Test


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  3. 3
    Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors

    المؤلفون: Jian Zou, Qiuju Xun, Zhang Zhang, Zhen Wang, Zhengchao Tu, Yingqiang Liu, Linjiang Tong, Hua Xie, Ke Ding, Xiaoyun Lu, Yong Xu, Jinfeng Luo, Minhao Huang

    المصدر: Journal of Medicinal Chemistry. 61:2353-2371

    مصطلحات موضوعية: Male, Models, Molecular, 0301 basic medicine, Biological Availability, Antineoplastic Agents, Rats, Sprague-Dawley, Colony stimulating factor 1 receptor, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, ErbB Receptors, 0302 clinical medicine, Cell Movement, Drug Discovery, Animals, Structure–activity relationship, Epidermal growth factor receptor, Receptor, Protein Kinase Inhibitors, IC50, Molecular Structure, biology, Kinase, Macrophages, Rats, Pyrimidines, RAW 264.7 Cells, 030104 developmental biology, Neutrophil Infiltration, chemistry, Biochemistry, Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Drug Design, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Lead compound

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a80fbb39b1b47a21f056bddbd73d071Test
    https://doi.org/10.1021/acs.jmedchem.7b01612Test


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  4. 4
    Discovery of a novel azetidine scaffold for colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors by the use of docking models

    المؤلفون: Yasunori Hase, Kazutaka Ikegashira, Takayuki Yamasaki, Satoki Doi, Taku Ikenogami, Koji Inagaki, Tsuyoshi Adachi, Hiromasa Hashimoto, Takayuki Yamaguchi, Yoshihisa Koga

    المصدر: Bioorganicmedicinal chemistry letters. 29(1)

    مصطلحات موضوعية: Scaffold, Stereochemistry, Clinical Biochemistry, Azetidine, Pharmaceutical Science, 01 natural sciences, Biochemistry, Colony stimulating factor 1 receptor, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Humans, Receptor, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Docking (molecular), Receptors, Granulocyte-Macrophage Colony-Stimulating Factor, Molecular Medicine, Azetidines

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d709947508bc3b3d064a15b58e90d84Test
    https://pubmed.ncbi.nlm.nih.gov/30442420Test


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  5. 5
    Growth Factors of Lower Vertebrates

    المؤلفون: Tiehui Wang, Christopher J. Secombes, Miodrag Belosevic, Patrick C. Hanington

    المصدر: Journal of Biological Chemistry. 282:31865-31872

    مصطلحات موضوعية: Macrophage colony-stimulating factor, medicine.medical_specialty, Mononuclear cell proliferation, Cellular differentiation, Spleen, Cell Biology, Biology, Biochemistry, Cell biology, chemistry.chemical_compound, Endocrinology, Macrophage Colony-Stimulating Factor 1, medicine.anatomical_structure, chemistry, Internal medicine, medicine, Phorbol, Progenitor cell, Receptor, Molecular Biology

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0816d2c5c5f2830ef15935cc144d6c8eTest
    https://doi.org/10.1074/jbc.m706278200Test


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  6. 6
    A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor

    المؤلفون: Hang Dinh, Gael A Manes, Thao Nguyen, Glen M. Scholz, Paul J. Masendycz, John A. Hamilton, Adrian Achuthan

    المصدر: FEBS Journal. 273:1791-1804

    مصطلحات موضوعية: MAP Kinase Kinase 4, Molecular Sequence Data, Proto-Oncogene Proteins pp60(c-src), Receptor, Macrophage Colony-Stimulating Factor, Biology, Kidney, Ligands, Proto-Oncogene Mas, Biochemistry, Receptor tyrosine kinase, Colony stimulating factor 1 receptor, Mice, chemistry.chemical_compound, Bone Marrow, Serine, Animals, Humans, 5-HT5A receptor, Amino Acid Sequence, Proto-Oncogene Proteins c-cbl, Phosphorylation, Molecular Biology, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Sequence Homology, Amino Acid, Reverse Transcriptase Polymerase Chain Reaction, Macrophage Colony-Stimulating Factor, Macrophages, GRB10, Tyrosine phosphorylation, Cell Biology, Molecular biology, Cell biology, Mice, Inbred C57BL, chemistry, ROR1, biology.protein, Tyrosine, Female, Proto-Oncogene Proteins c-akt, Tyrosine kinase, Signal Transduction

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11366aa2db30df2ae0b318a5c0bd72e4Test
    https://doi.org/10.1111/j.1742-4658.2006.05199.xTest


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  7. 7
    A Juxtamembrane Tyrosine in the Colony Stimulating Factor-1 Receptor Regulates Ligand-induced Src Association, Receptor Kinase Function, and Down-regulation

    المؤلفون: Angel W.-M. Lee, Cynthia M. Rohde, Jason P. Schrum

    المصدر: Journal of Biological Chemistry. 279:43448-43461

    مصطلحات موضوعية: Models, Molecular, Protein Conformation, Molecular Sequence Data, Receptor, Macrophage Colony-Stimulating Factor, Ligands, Biochemistry, Receptor tyrosine kinase, Colony stimulating factor 1 receptor, chemistry.chemical_compound, Cell Line, Tumor, Humans, Amino Acid Sequence, Molecular Biology, Protein kinase B, Conserved Sequence, Binding Sites, Sequence Homology, Amino Acid, biology, Autophosphorylation, Receptor Protein-Tyrosine Kinases, Tyrosine phosphorylation, Cell Biology, Cell biology, Kinetics, Proto-Oncogene Proteins c-kit, src-Family Kinases, Amino Acid Substitution, Gene Expression Regulation, chemistry, Mutagenesis, Site-Directed, biology.protein, Cancer research, Tyrosine, Phosphorylation, Signal transduction, Sequence Alignment, Cell Division, Proto-oncogene tyrosine-protein kinase Src

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9a7432a61e476580464c9417f42b15Test
    https://doi.org/10.1074/jbc.m314170200Test


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  8. 8
    Colony Stimulating Factor 1 Receptor (CSF1R) As a Potential Novel Therapeutic Target in CLL

    المؤلفون: Anupriya Agarwal, Stephen E. Spurgeon, Marc M. Loriaux, Hibery Ho, Tyler Sweeney, Elie Traer, Jeffrey W. Tyner, Brian J. Druker, David Chantry, Patrice Lee

    المصدر: Blood. 126:4439-4439

    مصطلحات موضوعية: Oncology, medicine.medical_specialty, Immunology, Population, Biochemistry, Colony stimulating factor 1 receptor, chemistry.chemical_compound, Internal medicine, Medicine, Bruton's tyrosine kinase, education, health care economics and organizations, Tumor microenvironment, education.field_of_study, biology, business.industry, Monocyte, Cell Biology, Hematology, medicine.disease, Leukemia, medicine.anatomical_structure, chemistry, Ibrutinib, biology.protein, business, Idelalisib

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::808b5baf0478bfab1c024489a2f88d42Test
    https://doi.org/10.1182/blood.v126.23.4439.4439Test


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  9. 9
    Activation of a phosphatidylcholine-specific phospholipase C by colony stimulating factor 1 receptor requires tyrosine phosphorylation and a guanine nucleotide-binding protein

    المؤلفون: Goutam Ghosh Choudhury, Victor L. Sylvia, Alan Y. Sakaguchi

    المصدر: Journal of Biological Chemistry. 266:23147-23151

    مصطلحات موضوعية: Phospholipase C, biology, Tyrosine phosphorylation, Cell Biology, Protein tyrosine phosphatase, Biochemistry, Receptor tyrosine kinase, Colony stimulating factor 1 receptor, chemistry.chemical_compound, chemistry, Phosphoinositide phospholipase C, biology.protein, Molecular Biology, Tyrosine kinase, Phosphatidylcholine phospholipase C activity

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7582387bdf5b75d1227c2e8e9b225729Test
    https://doi.org/10.1016/s0021-9258Test(18)54475-6


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  10. 10
    Ligand-Induced Phosphorylation of the Colony-Stimulating Factor 1 Receptor Can Occur through an Intermolecular Reaction That Triggers Receptor Down Modulation

    المؤلفون: M Ohtsuka, James R. Downing, Martine F. Roussel, Charles J. Sherr

    المصدر: Europe PubMed Central

    مصطلحات موضوعية: Macrophage colony-stimulating factor, Phosphopeptides, Receptors, Cell Surface, Antigen-Antibody Complex, Biology, Ligands, Transfection, Tropomyosin receptor kinase C, Peptide Mapping, Antibodies, Cell Line, Colony stimulating factor 1 receptor, chemistry.chemical_compound, Colony-Stimulating Factors, Receptors, Colony-Stimulating Factor, Animals, Tyrosine, Amino Acids, Phosphorylation, Receptor, Molecular Biology, Cells, Cultured, Tyrosine phosphorylation, Cell Biology, Interleukin-13 receptor, Cell biology, chemistry, Biochemistry, bacteria, Research Article

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2219109ca89a339be2db686f530e6e1Test
    https://doi.org/10.1128/mcb.10.4.1664-1671.1990Test


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