التفاصيل البيبلوغرافية
| العنوان: |
Detection of new phytochemical compounds from Vassobia breviflora (Sendtn.) Hunz: antioxidant, cytotoxic, and antibacterial activity of the hexane extract. |
| المؤلفون: |
Rossato Viana, Altevir1 (AUTHOR) rossato.viana@hotmail.com, Godoy Noro, Bruna2 (AUTHOR), Santos, Daniel3 (AUTHOR), Wolf, Katianne4 (AUTHOR), Sudatti Das Neves, Yasmin5 (AUTHOR), Moresco, Rafael Noal5 (AUTHOR), Ourique, Aline Ferreira4 (AUTHOR), Moraes Flores, Erico Marlon3 (AUTHOR), Rhoden, Cristiano Rodrigo Bohn4,6 (AUTHOR), Maria Fontanari Krause, Luciana7 (AUTHOR), Stefanello Vizzotto, Bruno8 (AUTHOR) |
| المصدر: |
Journal of Toxicology & Environmental Health: Part A. 2023, Vol. 86 Issue 2/3, p51-68. 18p. |
| مصطلحات موضوعية: |
*OXIDANT status, *ANTIBACTERIAL agents, *PANTOTHENIC acid, *PHYTOCHEMICALS, *HEXANE, *REACTIVE oxygen species, *PLANT extracts |
| مصطلحات جغرافية: |
SOUTH America |
| مستخلص: |
Vassobia breviflora (Sendtn.) Hunz is a plant of the Solanaceae family from South America and there are no apparent studies reported on the biological activity of the hexane extract. The aim of this investigation was to conduct phytochemical analyses using ESI-TOF-MS, while antioxidant activities were evaluated by the following methods 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical capture (ABTS), ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC), and total oxidant status (TOS). Antimicrobial activities were performed by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and antibiofilm formed. Cytotoxicity was measured by MTT and dsDNA PicoGreen tests, beyond the production of reactive oxygen species (ROS) determined by Dichlorodihydrofluorescein diacetate (DCFH-DA). The hexane extract showed the presence of 5 (choline, pantothenic acid, calystegine B, lanciphodylactone I, and 15"-cis-zeaxanthin) compounds detected. V. breviflora extract demonstrated reliable results utilizing different antioxidant methods. In antibacterial activity, V. breviflora extract exhibited inhibitory, bactericidal, and antibiofilm action in biofilm-forming bacteria. The hexane extract exhibited cytotoxicity against melanoma, lung cancer, glioblastoma, leukemia, uterine colon, and hepatocarcinoma tumor cells. In addition, all tested strains resulted in increased production of ROS. This plant extract may be considered in future as an alternative for development of new therapeutic options aimed at the treatment of diverse pathologies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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