يعرض 1 - 10 نتائج من 23 نتيجة بحث عن '"Gregory R. J. Thatcher"', وقت الاستعلام: 1.41s تنقيح النتائج
  1. 1
    Design of SARS-CoV-2 PLpro Inhibitors for COVID-19 Antiviral Therapy Leveraging Binding Cooperativity

    المؤلفون: Saad Alqarni, Lijun Rong, Yangfeng Li, Hyun Lee, Fei Huang, Youngjin Kwon, Rui Xiong, Zhengnan Shen, Deyu Kong, Oleksii Dubrovskyi, Laura Cooper, Kiira Ratia, Gregory R. J. Thatcher

    المصدر: Journal of Medicinal Chemistry
    bioRxiv

    مصطلحات موضوعية: Models, Molecular, Proteases, medicine.medical_treatment, Coronavirus Papain-Like Proteases, Cooperativity, Microbial Sensitivity Tests, Cysteine Proteinase Inhibitors, Crystallography, X-Ray, Antiviral Agents, Article, Ubiquitin, Drug Discovery, medicine, Tumor Cells, Cultured, Humans, Binding site, Pandemics, Protease, Binding Sites, biology, Chemistry, COVID-19, Surface Plasmon Resonance, Cell biology, COVID-19 Drug Treatment, Viral replication, biology.protein, Microsomes, Liver, Molecular Medicine, Cysteine, Deubiquitination

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce88db71cdeea671844b11248a4fce3Test
    http://europepmc.org/articles/PMC8547495Test


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  2. 2
    Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments

    المؤلفون: F. Fata, Gregory R. J. Thatcher, Nicola Demitri, Haining Lyu, Francesco Angelucci, Maurizio Polentarutti, Luana Di Leandro, Pavel A. Petukhov, David L. Williams, Matteo Ardini, I. Silvestri, Rodolfo Ippoliti, Adele Di Matteo

    المصدر: ACS Infect Dis
    ACS Infectious Diseases 7 (2021): 1932–1944. doi:10.1021/acsinfecdis.0c00909
    info:cnr-pdr/source/autori:Fata F.; Silvestri I.; Ardini M.; Ippoliti R.; Di Leandro L.; Demitri N.; Polentarutti M.; Di Matteo A.; Lyu H.; Thatcher G.R.J.; Petukhov P.A.; Williams D.L.; Angelucci F./titolo:Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments/doi:10.1021%2Facsinfecdis.0c00909/rivista:ACS Infectious Diseases/anno:2021/pagina_da:1932/pagina_a:1944/intervallo_pagine:1932–1944/volume:7

    مصطلحات موضوعية: 0301 basic medicine, NADPH:disulfide oxidoreductase, 030106 microbiology, Allosteric regulation, Druggability, enzyme inhibitor, fragment, NADPH Oxidoreductases, Article, 03 medical and health sciences, Multienzyme Complexes, schistosomiasis, Animals, NADH, NADPH Oxidoreductases, Binding site, allosteric effect, Antiparasitic Agents, Chemistry, Drug discovery, secondary site, Schistosoma mansoni, Small molecule, 030104 developmental biology, Infectious Diseases, Biochemistry, NADH, NADPH binding, Target protein, Thioredoxin

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe0e53fbc90cd97304981d5aa9fa155Test
    https://pubmed.ncbi.nlm.nih.gov/33950676Test


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  3. 3
    Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry

    المؤلفون: Hyun Lee, Adam Schafer, Lijun Rong, Norton P. Peet, Yangfeng Li, Raghad Nowar, Rui Xiong, Erica Ollmann Saphire, Han Cheng, Michael Caffrey, Laura Cooper, Benjamin E. Ramirez, Gregory R. J. Thatcher

    المصدر: PLoS Pathogens, Vol 17, Iss 2, p e1009312 (2021)
    PLoS Pathogens

    مصطلحات موضوعية: RNA viruses, Glycobiology, Pathology and Laboratory Medicine, medicine.disease_cause, Biochemistry, Binding Analysis, 0302 clinical medicine, Viral Envelope Proteins, Chlorocebus aethiops, Medicine and Health Sciences, Biology (General), chemistry.chemical_classification, 0303 health sciences, Organic Compounds, Ebolavirus, Small molecule, Cell biology, Chemistry, medicine.anatomical_structure, Medical Microbiology, Filoviruses, Viral Pathogens, Viruses, Physical Sciences, Host-Pathogen Interactions, Engineering and Technology, Marburg Virus, Pathogens, Cellular Structures and Organelles, medicine.symptom, Ebola Virus, Research Article, Biotechnology, Viral Entry, QH301-705.5, Immunology, Drug design, Bioengineering, Research and Analysis Methods, Antiviral Agents, Microbiology, Small Molecule Libraries, 03 medical and health sciences, Viral entry, Virology, Lysosome, Genetics, medicine, Animals, Humans, Binding site, Microbial Pathogens, Vero Cells, Molecular Biology, Chemical Characterization, Glycoproteins, 030304 developmental biology, Virus Glycoproteins, Ebola virus, Biology and life sciences, Hemorrhagic Fever Viruses, Organic Chemistry, Organisms, Chemical Compounds, Cell Biology, Hemorrhagic Fever, Ebola, Virus Internalization, RC581-607, chemistry, Mechanism of action, Small Molecules, A549 Cells, Parasitology, Immunologic diseases. Allergy, Lysosomes, Glycoprotein, Viral Transmission and Infection, 030217 neurology & neurosurgery

    الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e2e2dba33d62491007061fd573a91bTest
    https://doaj.org/article/513584dcab26402ea212101359422d10Test


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  4. 4
    صورة
    Compound structures and results of cytotoxicity testing for small molecules in Fig 2; specificity testing for toremifene and fluoxetine pseudotyped influenza H5N1 and vesicular stomatitis virus (VSV) (S1 Table).

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/Compound_structures_and_results_of_cytotoxicity_testing_for_small_molecules_in_Fig_2_specificity_testing_for_toremifene_and_fluoxetine_pseudotyped_influenza_H5N1_and_vesicular_stomatitis_virus_VSV_S1_Table_/13717674Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.s004Test

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  5. 5
    صورة
    A model of multiple mechanisms of action for entry inhibitors targeting EBOV and MARV.

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/A_model_of_multiple_mechanisms_of_action_for_entry_inhibitors_targeting_EBOV_and_MARV_/13717716Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.g007Test

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  6. 6
    صورة
    Percent virus infectivity as compared to WT-Ebola virus and WT-Marburg virus.

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/Percent_virus_infectivity_as_compared_to_WT-Ebolavirus_and_WT-Marburgvirus_/13717665Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.s001Test

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  7. 7
    Mutations were made at various residues in two regions on interest (the Cap region and internal fusion loop region) of the MARV GP.

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/dataset/Mutations_were_made_at_various_residues_in_two_regions_on_interest_the_Cap_region_and_internal_fusion_loop_region_of_the_MARV_GP_/13717692Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.s010Test

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  8. 8
    صورة
    Sequence comparison of ebolaviruses (Ebola, Bundibugyo, Tai Forest, Sudan, Reston), Marburg virus, and Lloviu virus in the fusion loop region (A.) and HR2 region (B.).

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/Sequence_comparison_of_Ebolavirus_Zaire_Bundibugyo_Tai_Forest_Sudan_Reston_Marburgvirus_Angola_and_Cuevavirus_in_the_fusion_loop_region_A_and_HR2_region_B_/13717668Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.s002Test

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  9. 9
    صورة
    Structure of EBOV and MARV glycoproteins and mutational analysis of tyrosine 517 reveals a MARV-like phenotype.

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/Structure_of_EBOV_and_MARV_glycoproteins_and_mutational_analysis_of_tyrosine_517_reveals_a_MARV-like_phenotype_/13717698Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.g001Test

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  10. 10
    صورة
    Toremifene and fluoxetine show synergism against pseudotyped WT-EBOV but not WT-MARV.

    المؤلفون: Adam Schafer (9407069), Rui Xiong (1434895), Laura Cooper (6270800), Raghad Nowar (9407075), Hyun Lee (468713), Yangfeng Li (8107268), Benjamin E. Ramirez (7930511), Norton P. Peet (544446), Michael Caffrey (151843), Gregory R. J. Thatcher (7942685), Erica Ollmann Saphire (10099368), Han Cheng (475615), Lijun Rong (89163)

    مصطلحات موضوعية: Biophysics, Biochemistry, Medicine, Cell Biology, Molecular Biology, Pharmacology, Biotechnology, Developmental Biology, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, anti-filoviral agents, EBOV GP inhibitors, filovirus entry, mechanism, binding site, molecule entry inhibitors, Marburg virus GP inhibitors, HR 2 domain, Ebola virus glycoprotein, GP inhibitors increases drug exposure, fusion loop region

    العلاقة: https://figshare.com/articles/figure/Toremifene_and_fluoxetine_show_synergism_against_pseudotyped_WT-EBOV_but_not_WT-MARV_/13717713Test

    الإتاحة: https://doi.org/10.1371/journal.ppat.1009312.g006Test

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