التفاصيل البيبلوغرافية
| العنوان: |
Where Is Bacosine in Commercially Available Bacopa monnieri ? |
| المؤلفون: |
Ritter, Stefanie, Urmann, Corinna, Herzog, Rainer, Glaser, Jan, Bieringer, Sebastian, Geisberger, Thomas, Eisenreich, Wolfgang, Riepl, Herbert |
| المصدر: |
Planta Medica; 2020, Vol. 86 Issue 8, p565-570, 6p |
| مصطلحات موضوعية: |
DIETARY supplements, HIGH performance liquid chromatography, MASS spectrometry, MEDICINAL plants, MOLECULAR structure, NUCLEAR magnetic resonance spectroscopy, SPECTRUM analysis, PHYTOCHEMICALS, PLANT extracts |
| مستخلص: |
Bacopa monnieri is an Ayurvedic plant with rising interest in the pharmacological effects of its extract and constituents, including flavonoids, saponins, and triterpenes such as cucurbitacins, betulinic acid, and bacosine. The latter two compounds are isomeric 3-hydroxy lupenoic acids, which vary only in the arrangement of the carboxylic acid group and the methyl group at C-27 and C-28 and the orientation of the hydroxy group at C-3. In this study, we have reinvestigated the contents of betulinic acid and bacosine, respectively, in extracts from various commercially available B. monnieri powders and food supplements. To our surprise, HPLC-ion trap time-of-flight analyses identified only betulinic acid, but not bacosine, in all extracts under study, which was verified by GC-MS, HPLC-ELSD, 1D NMR (1 H,13 C), and 2D NMR (1 H,1 H COSY,1 H,13 C HMBC,1 H,13 C HSQC,1 H,1 H NOESY) experiments. Moreover, it turned out that commercially available reference samples of bacosine were structurally identical with betulinic acid. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
