دورية أكاديمية
Psoriasis is associated with increased beta-defensin genomic copy number.
| العنوان: | Psoriasis is associated with increased beta-defensin genomic copy number. |
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| المؤلفون: | Hollox, EJ, Huffmeier, U, Zeeuwen, PL, Palla, R, Lascorz, J, Rodijk-Olthuis, D, van de Kerkhof PC, Traupe, H, de Jongh G, den Heijer M, Reis, A, Armour, JA, Schalkwijk, J |
| المصدر: | PubMed ; http://www.ncbi.nlm.nih.gov/pubmedTest/ |
| سنة النشر: | 2012 |
| المجموعة: | University of Leicester: Leicester Research Archive (LRA) |
| مصطلحات موضوعية: | Case-Control Studies, Chromosomes, Human, Pair 8, Gene Dosage, Genetic Predisposition to Disease, Humans, Polymorphism, Genetic, Single Nucleotide, Psoriasis, beta-Defensins |
| الوصف: | Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis. ; 16448 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | metadata |
| اللغة: | English |
| تدمد: | 1546-1718 |
| العلاقة: | NAT GENET, 2008, 40 (1), pp. 23-25; http://hdl.handle.net/2381/15526Test; ng.2007.48 |
| DOI: | 10.1038/ng.2007.48 |
| الإتاحة: | https://doi.org/10.1038/ng.2007.48Test http://hdl.handle.net/2381/15526Test |
| رقم الانضمام: | edsbas.311BD972 |
| قاعدة البيانات: | BASE |
| تدمد: | 15461718 |
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| DOI: | 10.1038/ng.2007.48 |