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MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma

التفاصيل البيبلوغرافية
العنوان: MLN4924 Synergistically Enhances Cisplatin-induced Cytotoxicity via JNK and Bcl-xL Pathways in Human Urothelial Carcinoma
المؤلفون: Chung-Sheng Shi, Chen-Hsun Hsu, Chih-Kang Chiang, Ju-Ton Hsieh, Hong-Chiang Chang, June-Tai Wu, Yeong-Shiau Pu, Shing-Hwa Liu, I-Lin Ho, Kuan-Lin Kuo, Wei-Chou Lin, Chien-Tso Chou, Kuo-How Huang, Yu-Chieh Tsai
المصدر: Scientific Reports
بيانات النشر: Nature Publishing Group, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Pathology, medicine.medical_specialty, NEDD8 Protein, MAP Kinase Kinase 4, bcl-X Protein, Mice, Nude, Bcl-xL, Caspase 3, Antineoplastic Agents, Apoptosis, Cyclopentanes, Article, Histones, Mice, Cell Line, Tumor, medicine, Carcinoma, Animals, Humans, Viability assay, Cytotoxicity, Ubiquitins, Cisplatin, Caspase 7, Carcinoma, Transitional Cell, Multidisciplinary, Bladder cancer, biology, business.industry, Drug Synergism, medicine.disease, Xenograft Model Antitumor Assays, Gene Expression Regulation, Neoplastic, Drug Combinations, Pyrimidines, Urinary Bladder Neoplasms, biology.protein, Cancer research, Neoplasm Grading, Poly(ADP-ribose) Polymerases, business, medicine.drug, Signal Transduction
الوصف: Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial carcinoma. However, the response rate is only 40–65%. This study investigated the anti-tumor effect and underlying mechanisms of the combination of cisplatin and the NEDD8-activating enzyme inhibitor MLN4924 in human bladder urothelial carcinoma. The combination of cisplatin and MLN4924 exerted synergistic cytotoxicity on two high-grade bladder urothelial carcinoma cell lines, NTUB1 and T24 (combination index
اللغة: English
تدمد: 2045-2322
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91b368fbe9a45c4c1d2bacf1fa7b401Test
http://europepmc.org/articles/PMC4655337Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....e91b368fbe9a45c4c1d2bacf1fa7b401
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20452322