التفاصيل البيبلوغرافية
| العنوان: |
The impact of bacterial colonization on graft success after total pancreatectomy with autologous islet transplantation: considerations for early definitive surgical intervention. |
| المؤلفون: |
Jolissaint, Joshua S., Langman, Linda W., DeBolt, Claire L., Tatum, Jacob A., Martin, Allison N., Wang, Andrew Y., Strand, Daniel S., Zaydfudim, Victor M., Adams, Reid B., Brayman, Kenneth L. |
| المصدر: |
Clinical Transplantation; Nov2016, Vol. 30 Issue 11, p1473-1479, 7p |
| مصطلحات موضوعية: |
BACTERIAL colonies, PANCREATECTOMY, AUTOTRANSPLANTATION, ISLANDS of Langerhans transplantation, BACTERIAL contamination, PERIOPERATIVE care |
| مستخلص: |
Objective The purpose of this study was to determine whether bacterial contamination of islets affects graft success after total pancreatectomy with islet autotransplantation ( TPIAT). Background Factors associated with insulin independence after TPIAT are inconclusive. Although bacterial contamination does not preclude transplantation, the impact of bacterial contamination on graft success is unknown. Methods Patients who received TPIAT at the University of Virginia between January 2007 and January 2016 were reviewed. Patient charts were reviewed for bacterial contamination and patients were prospectively contacted to assess rates of insulin independence. Results There was no significant difference in demographic or perioperative data between patients who achieved insulin independence and those who did not. However, six of 27 patients analyzed (22.2%) grew bacterial contaminants from culture of the final islet preparations. These patients had significantly lower islet yield and C-peptide at most recent follow-up ( P<.05), and none of these patients achieved insulin independence. Conclusions Islet transplant solutions are often culture positive, likely secondary to preprocurement pancreatic manipulation and introduction of enteric flora. Although autotransplantation of culture-positive islets is safe, it is associated with higher rates of graft failure and poor islet yield. Consideration should be given to identify patients who may develop refractory chronic pancreatitis and offer early operative management to prevent bacterial colonization. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
