d -Peptidase Activity in a Marine Mollusk Detoxifies a Nonribosomal Cyclic Lipopeptide: An Ecological Model to Study Antibiotic Resistance
| العنوان: | |
|---|---|
| المؤلفون: | Julio Sáez-Vásquez, Delphine Raviglione, Isabelle Bonnard, Nicolas Inguimbert, Laurine Darcel, Suzanne C. Mills, Bernard Banaigs, Louis Bornancin |
| المساهمون: | Centre de recherches insulaires et observatoire de l'environnement (CRIOBE), Université de Perpignan Via Domitia (UPVD)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Génome et développement des plantes (LGDP), Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), ANR-10-LABX-0008,CORAIL,Coral reefs facing global change(2010), ANR-18-EURE-0019,TULIP-GSR,The Toulouse-Perpignan(2018), ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010) |
| المصدر: | Journal of Medicinal Chemistry Journal of Medicinal Chemistry, American Chemical Society, In press, ⟨10.1021/acs.jmedchem.1c00249⟩ |
| بيانات النشر: | American Chemical Society (ACS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cyanobacteria, Stylocheilus, Cyclic lipopeptide, Zoology, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, Peptides, Cyclic, 01 natural sciences, 03 medical and health sciences, Antibiotic resistance, Drug Resistance, Bacterial, Drug Discovery, Animals, 14. Life underwater, Anabaena torulosa, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Chemistry, Laxaphycin B, biology.organism_classification, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Mollusca, bacteria, Molecular Medicine, Invisibility cloak, Peptide Hydrolases |
| الوصف: | International audience; In the marine environment, sessile cyanobacteria have developed chemical strategies for protection against grazers. In turn, herbivores have to circumvent these defenses and in certain cases even take advantage of them as shelter from their own predators. This is the case of Stylocheilus striatus, a sea hare that feeds on Anabaena torulosa, a cyanobacterium that produces toxic cyclic lipopeptides of the laxaphycin B family. S. striatus consumes the cyanobacterium without being affected by the toxicity of its compounds and also uses it as an invisibility cloak against predators. In this article, using different substrates analogous to laxaphycin B, we demonstrate the presence of an enzyme in the digestive gland of the mollusk that is able to biotransform laxaphycin B derivatives. The enzyme belongs to the poorly known family of d-peptidases that are suspected to be involved in antibiotic resistance. |
| تدمد: | 1520-4804 0022-2623 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04121538c26942e4cfcbe3cea11db4fTest https://doi.org/10.1021/acs.jmedchem.1c00249Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a04121538c26942e4cfcbe3cea11db4f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15204804 00222623 |
|---|