التفاصيل البيبلوغرافية
| العنوان: |
Efficacy of combination therapy with probiotics and mosapride in patients with IBS without diarrhea: a randomized, double-blind, placebo-controlled, multicenter, phase II trial. |
| المؤلفون: |
Choi, C. H., Kwon, J. G., Kim, S. K., Myung, S.‐J., Park, K. S., Sohn, C.‐I., Rhee, P.‐L., Lee, K. J., Lee, O. Y., Jung, H.‐K., Jee, S. R., Jeen, Y. T., Choi, M.‐G., Choi, S. C., Huh, K. C., Park, H. |
| المصدر: |
Neurogastroenterology & Motility; May2015, Vol. 27 Issue 5, p705-716, 12p |
| مصطلحات موضوعية: |
PROBIOTICS, RANDOMIZED controlled trials, IRRITABLE colon, GASTROINTESTINAL diseases, BACILLUS subtilis, ENTEROCOCCUS faecium, PLACEBOS |
| مستخلص: |
Background Probiotics can be beneficial in irritable bowel syndrome ( IBS). Mosapride citrate, a selective 5- HT4 receptor agonist, stimulates gastrointestinal motility. We investigated the efficacy of combination therapy with probiotics and mosapride for non-diarrheal-type IBS. Methods Two hundred and eighty-five IBS patients were randomly assigned to either a combination of probiotics ( Bacillus subtilis and Streptococcus faecium) and mosapride at one of four different doses or a placebo for 4 weeks. The primary outcome was the proportion of patients experiencing adequate relief ( AR) of global IBS symptoms at week 4. The secondary outcomes included subject's global assessment ( SGA) of IBS symptom relief, individual symptoms, stool parameters, and IBS-quality of life. Key Results The proportion of AR at week 4 was significantly higher in all treatment groups compared to the placebo group (53.7% in group 1, 55.0% in group 2, 55.2% in group 3, 53.6% in group 4 [the highest dose], and 35.1% in placebo group, respectively, p < 0.05). The proportion of patients reporting 'completely or considerably relieved' in the SGA was higher in the treatment groups than in the placebo group. The abdominal pain/discomfort score in the treatment group 4 was more prominently improved compared with that of the placebo group. In patients with constipation-predominant IBS, the improvements in stool frequency and consistency were significantly higher in the treatment groups 4 and 1, respectively, than those in the placebo group. Conclusions & Inferences Combination therapy with probiotics and mosapride is effective for relief of symptoms in patients with non-diarrheal-type IBS. The study has been registered in the US National Library of Medicine (, NCT01505777). [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
