Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development
| العنوان: | Role of antigen specific T and B cells in systemic and mucosal immune responses in ETEC and Shigella infections, and their potential to serve as correlates of protection in vaccine development |
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| المؤلفون: | Ann-Mari Svennerholm, Monica A. McArthur, Sachin Mani, Firdausi Qadri, Daniel Cohen, Franklin R. Toapanta, Bert Devriendt, Marcelo B. Sztein, Armelle Phalipon |
| المساهمون: | PATH [Seattle], University of Maryland School of Medicine, University of Maryland System, International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), University of Gothenburg (GU), Universiteit Gent = Ghent University (UGENT), Pathogénie microbienne moléculaire, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sackler Faculty of Medicine, Tel Aviv University (TAU), Research outlined in this manuscript were supported in part by the following grants - grants R01-AI036525, U19-AI082655 (Cooperative Center for Human Immunology [CCHI]) and U19-AI109776 (Center of Excellence for Translational Research [CETR] from the National Institute of Allergy and Infectious Diseases (NIAID) at the National Institutes of Health (NIH), grant GR01263 through PATH Enteric Vaccine Inititative (EVI), with additional support from the Bill and Melinda Gates Foundation and the Swedish Research Council, and grant 261472 'STOPENTERICS' from the European Union Seventh Framework Programme. In addition, B. Devriendt was supported by a postdoctoral grant from Fonds voor Wetenschappelijk Onderzoek – Vlaanderen [FWO, Research Foundation, Flanders]. The manuscript content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health or any other granting/funding organizations or agencies., European Project: 261472,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,STOPENTERICS(2010), Universiteit Gent = Ghent University [Belgium] (UGENT), Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Tel Aviv University [Tel Aviv], Phalipon, Armelle, Vaccination against Shigella and ETEC: novel antigens, novel approaches - STOPENTERICS - - EC:FP7:HEALTH2010-11-01 - 2016-10-31 - 261472 - VALID |
| المصدر: | Vaccine Vaccine, 2019, 37 (34), pp.4787-4793. ⟨10.1016/j.vaccine.2019.03.040⟩ VACCINE Vaccine, Elsevier, 2019, 37 (34), pp.4787-4793. ⟨10.1016/j.vaccine.2019.03.040⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | SERUM ANTIBODIES, T-Lymphocytes, medicine.disease_cause, DOUBLE-BLIND, Immunogenicity, Vaccine, 0302 clinical medicine, Shigella Vaccines, Enterotoxigenic Escherichia coli, Medicine and Health Sciences, ORAL VACCINE, Immunocorrelate, Shigella, 030212 general & internal medicine, Escherichia coli (ETEC), Escherichia coli Infections, Correlates of protection (CoP), B-Lymphocytes, Clinical Trials as Topic, Immunity, Cellular, Enterotoxigenic, Escherichia coli Vaccines, Effector, RESEARCH-AND-DEVELOPMENT, Antibodies, Bacterial, 3. Good health, O-SPECIFIC POLYSACCHARIDE, Infectious Diseases, medicine.anatomical_structure, SAFETY, Molecular Medicine, Mucosal antibodies, CONJUGATE VACCINE, IgA, Diarrhea, ANTIBODY-RESPONSES, IgG, T cell, 030231 tropical medicine, T cells, Article, FLEXNERI 2A, 03 medical and health sciences, Immune system, Antigen, Conjugate vaccine, medicine, Humans, Immunity, Mucosal, ENTEROTOXIGENIC ESCHERICHIA-COLI, Dysentery, Bacillary, B cells, General Veterinary, General Immunology and Microbiology, business.industry, Public Health, Environmental and Occupational Health, Biology and Life Sciences, Congresses as Topic, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Enterotoxigenic Escherichia coli (ETEC), Immunology, Immunization, [SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, business, Immunologic Memory |
| الوصف: | The generation of robust systemic and mucosal antibody and cell-mediated immune (CMI) responses that are protective, long-lasting, and can quickly be recalled upon subsequent re-exposure to the cognate antigen is the key to the development of effective vaccine candidates. These responses, whether they represent mechanistic or non-mechanistic immunological correlates of protection, usually entail the activation of T cell memory and effector subsets (T-CMI) and induction of long-lasting memory B cells. However, for ETEC and Shigella, the precise role of these key immune cells in primary and secondary (anamnestic) immune responses remains ill-defined. A workshop to address immune correlates for ETEC and Shigella, in general, and to elucidate the mechanistic role of T-cell subsets and B-cells, both systemically and in the mucosal microenvironment, in the development of durable protective immunity against ETEC and Shigella was held at the recent 2nd Vaccines against Shigella and ETEC (VASE) conference in June 2018. This report is a summary of the presentations and the discussion that ensued at the workshop. (C) 2019 The Authors. Published by Elsevier Ltd. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0264-410X 1873-2518 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf1012336a201a024a29cdb8a2c5e85Test https://hal-pasteur.archives-ouvertes.fr/pasteur-02874931Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5cf1012336a201a024a29cdb8a2c5e85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0264410X 18732518 |
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