التفاصيل البيبلوغرافية
| العنوان: |
HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound. |
| المؤلفون: |
Offersen, Rasmus, Yu, Wen-Han, Scully, Eileen P., Julg, Boris, Euler, Zelda, Sadanand, Saheli, Garcia-Dominguez, Dario, Zheng, Lu, Rasmussen, Thomas A., Jennewein, Madeleine F., Linde, Caitlyn, Sassic, Jessica, Lofano, Giuseppe, Vigano, Selena, Stephenson, Kathryn E., Fischinger, Stephanie, Suscovich, Todd J., Lichterfeld, Mathias, Lauffenburger, Douglas, Rosenberg, Erik S. |
| المصدر: |
Cell Reports; Dec2020, Vol. 33 Issue 11, pN.PAG-N.PAG, 1p |
| مستخلص: |
Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track with biological age, shift with vaccination, change with HIV reservoir size on therapy, and decrease in HIV and HCV infections. However, whether changes in antibody Fc biology also track with reservoir rebound time remains unclear. The identification of a biomarker that could forecast viral rebound time could significantly accelerate the downselection and iterative improvement of promising HIV viral eradication strategies. Using a comprehensive antibody Fc-profiling approach, the level of HIV-specific antibody Fc N-galactosylation is significantly associated with time to rebound after treatment discontinuation across three independent cohorts. Thus virus-specific antibody glycosylation may represent a promising, simply measured marker to track reservoir reactivation. • HIV-specific antibody glycosylation is associated with time to viral rebound • The glycosylation profile is also linked with altered functional antibody activity • Plasmablast expansions occur in tandem with antibody glycan shifts • B cell responses may act as biosensors for viral reactivation and control in tissues Using systems serology, Offersen et al. demonstrate that HIV-specific antibody Fc N-galactosylation is associated with longer time to viral rebound after discontinuation of antiretroviral treatment across three independent HIV cohorts. Thus, virus-specific antibody glycosylation may represent a promising, simply measured marker to track viral reservoir reactivation. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
