التفاصيل البيبلوغرافية
| العنوان: |
Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. |
| المؤلفون: |
Varghese, Abraham M., Rawstron, Andy, Newton, Darren, Tooze, Reuben M., Munir, Talha, Dickson, Marion, Doody, Gina M., Hillmen, Peter |
| المصدر: |
British Journal of Haematology; Sep2018, Vol. 182 Issue 6, p927-930, 4p, 2 Graphs |
| مصطلحات موضوعية: |
ANTIGENS, PATHOLOGICAL physiology, B cell receptors, KINASE inhibitors, CHRONIC lymphocytic leukemia, LYMPHOMAS |
| مستخلص: |
The article focuses on role of antigen stimulation in the pathophysiology of the disease and the development of B cell receptor (BCR) kinase inhibitors as potential therapeutic targets for expansion chronic lymphocytic leukaemia (CLL) research. It mentions aspects of CLL cell survival signalling and to be clinically effective in B-cell non-Hodgkin lymphoma (B-NHL). It also mentions series of diaminopyrimidine carboxamides (DAPC) with SYK inhibitory activity. |
| قاعدة البيانات: |
Complementary Index |
