Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis
| العنوان: | Decreased expression of zinc-alpha2-glycoprotein in hepatocellular carcinoma associates with poor prognosis |
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| المؤلفون: | Yan Li, Yan Huang, Mu Yan Cai, Chun Yi, Jing Ping Yun, Guo Bing Xie, Li Li Liu, Xuan Zhou, Chris Zhiyi Zhang, Lin Zi Li |
| المصدر: | Journal of Translational Medicine, Vol 10, Iss 1, p 106 (2012) Journal of Translational Medicine |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatocellular carcinoma, Down-Regulation, lcsh:Medicine, AZGP1, Biology, Real-Time Polymerase Chain Reaction, Zn-Alpha-2-Glycoprotein, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Metastasis, Downregulation and upregulation, Recurrence, medicine, Carcinoma, Humans, RNA, Messenger, DNA Primers, Medicine(all), Base Sequence, Biochemistry, Genetics and Molecular Biology(all), Research, Liver Neoplasms, lcsh:R, Seminal Plasma Proteins, General Medicine, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, digestive system diseases, Real-time polymerase chain reaction, Tissue Array Analysis, Cancer research, Female, Carcinogenesis |
| الوصف: | Background Zinc-alpha2-glycoprotein (AZGP1, ZAG) was recently demonstrated to be an important factor in tumor carcinogenesis. However, AZGP1 expression in hepatocellular carcinoma (HCC) and its significance remain largely unknown. Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to determine mRNA level of AZGP1 in 20 paired fresh HCC tissues. Clinical and pathological data of 246 HCC patients were collected. Tissue-microarray-based immunohistochemistry (IHC) was performed to examine AZGP1 expression in HCC samples. Relationship between AZGP1 expression and clinicopathological features was analyzed by Chi-square test, Kaplan-Meier analysis and Cox proportional hazards regression model. Results AZGP1 expression was significantly lower in 80.0% (16/20) of tumorous tissues than that in the corresponding adjacent nontumorous liver tissues (P P P = 0.013), liver cirrhosis (P = 0.002) and tumor differentiation (P = 0.025). Moreover, HCC patients with high AZGP1 expression survived longer, with better overall survival (P = 0.006) and disease-free survival (P = 0.025). In addition, low AZGP1 expression associated with worse relapse-free survival (P = 0.046) and distant metastatic progression-free survival (P = 0.036). Conclusion AZGP1 was downregulated in HCC and could be served as a promising prognostic marker for HCC patients. |
| تدمد: | 1479-5876 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3677fe38521d4e86cf438126809ec1cTest https://doi.org/10.1186/1479-5876-10-106Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3677fe38521d4e86cf438126809ec1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14795876 |
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