Regulation of autophagy by nuclear GAPDH and its aggregates in cancer and neurodegenerative disorders
| العنوان: | Regulation of autophagy by nuclear GAPDH and its aggregates in cancer and neurodegenerative disorders |
|---|---|
| المؤلفون: | Giovanna Butera, Francesca Masetto, Nidula Mullappilly, Maria Teresa Scupoli, Massimo Donadelli, Raffaella Pacchiana, Marta Palmieri |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 20, Iss 9, p 2062 (2019) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Programmed cell death, autophagy, DNA repair, Review, Mitochondrion, Biology, Models, Biological, Catalysis, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Neoplasms, medicine, Animals, Humans, cancer, Glycolysis, Physical and Theoretical Chemistry, GAPDH, aggregates, cell death, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, Glyceraldehyde 3-phosphate dehydrogenase, Organic Chemistry, Autophagy, Cancer, Glyceraldehyde-3-Phosphate Dehydrogenases, Neurodegenerative Diseases, General Medicine, medicine.disease, Computer Science Applications, Cell biology, Cytosol, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, 030220 oncology & carcinogenesis, biology.protein |
| الوصف: | Several studies indicate that the cytosolic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has pleiotropic functions independent of its canonical role in glycolysis. The GAPDH functional diversity is mainly due to post-translational modifications in different amino acid residues or due to protein–protein interactions altering its localization from cytosol to nucleus, mitochondria or extracellular microenvironment. Non-glycolytic functions of GAPDH include the regulation of cell death, autophagy, DNA repair and RNA export, and they are observed in physiological and pathological conditions as cancer and neurodegenerative disorders. In disease, the knowledge of the mechanisms regarding GAPDH-mediated cell death is becoming fundamental for the identification of novel therapies. Here, we elucidate the correlation between autophagy and GAPDH in cancer, describing the molecular mechanisms involved and its impact in cancer development. Since autophagy is a degradative pathway associated with the regulation of cell death, we discuss recent evidence supporting GAPDH as a therapeutic target for autophagy regulation in cancer therapy. Furthermore, we summarize the molecular mechanisms and the cellular effects of GAPDH aggregates, which are correlated with mitochondrial malfunctions and can be considered a potential therapeutic target for various diseases, including cancer and neurodegenerative disorders. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c896bd79d2da7da7bc6ecc35dc7984Test http://hdl.handle.net/11562/994653Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....58c896bd79d2da7da7bc6ecc35dc7984 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |