Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy
| العنوان: | Impaired Awareness of Hypoglycemia in Adults With Type 1 Diabetes Is Not Associated With Autonomic Dysfunction or Peripheral Neuropathy |
|---|---|
| المؤلفون: | Trond Sand, Kristian Bernhard Nilsen, Marit R. Bjørgaas, Brian M. Frier, Sandra Elise Olsen, Bjørn Olav Åsvold, Marit Stjern |
| المصدر: | Diabetes Care. 39:426-433 |
| بيانات النشر: | American Diabetes Association, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Research design, medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Hypoglycemia, 03 medical and health sciences, 0302 clinical medicine, Diabetic Neuropathies, Risk Factors, Interquartile range, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Risk factor, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Peripheral Nervous System Diseases, Awareness, Middle Aged, medicine.disease, Surgery, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Peripheral neuropathy, Autonomic Nervous System Diseases, Female, business, 030217 neurology & neurosurgery |
| الوصف: | OBJECTIVE Impaired awareness of hypoglycemia (IAH) is a risk factor for severe hypoglycemia in people with insulin-treated diabetes; autonomic neuropathy has been suggested to underlie its development. The aim was to evaluate a putative association between IAH and autonomic dysfunction using novel and sensitive measures of autonomic neural function. RESEARCH DESIGN AND METHODS Sixty-six adults with type 1 diabetes were studied, 33 with IAH and 33 with normal awareness of hypoglycemia (NAH), confirmed by formal testing. Participants were matched for age, sex, and diabetes duration. Clinical and laboratory evaluations included extensive autonomic function testing, peripheral nerve conduction studies, and quantitative sensory testing. Composite abnormality Z scores were used for group comparisons. RESULTS The IAH and NAH group had similar median (interquartile range) age of 48 (14.5) vs. 47 (14.5) years, diabetes duration of 30 (13.5) vs. 31 (13.5) years, and mean ± SD HbA1c 7.8 ± 2.2% vs. 8.1 ± 1.9%, respectively. The autonomic composite Z score did not differ between the two groups (mean difference −0.15, 95% CI −0.46, 0.16; P = 0.33), nor did the thermal detection (mean difference 0.15, 95% CI −0.31, 0.61; P = 0.51) or nerve conduction scores (mean difference 0.03, 95% CI −0.43, 0.49; P = 0.89). CONCLUSIONS In adults with type 1 diabetes, IAH was not associated with autonomic dysfunction or peripheral neuropathy. |
| تدمد: | 1935-5548 0149-5992 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782f29b4b95c817ef1be4b1a397ae415Test https://doi.org/10.2337/dc15-1469Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....782f29b4b95c817ef1be4b1a397ae415 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19355548 01495992 |
|---|